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Efficacy of dupilumab in real-life settings: a STROBE study
BackgroundDupilumab, a monoclonal antibody targeting IL-4 and IL-13, has demonstrated its efficacy in several clinical trials. However, to date,...
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Real life evaluation of AlphaMissense predictions in hematological malignancies
High-throughput sequencing plays a pivotal role in hematological malignancy diagnostics, but interpreting missense mutations remains challenging. In...
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Belimumab corticosteroid-sparing treatment in systemic lupus erythematosus: a real-life observational study (BESST study)
Data about the impact of Belimumab on corticosteroid sparing in real life are scarce. To assess the corticosteroid-sparing effect among patients with...
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Real-life experiences with galcanezumab and predictors for treatment response in Turkey
BackgroundThe complexity of clinical practice extends far beyond the controlled settings of trials, and there is a need for real-world studies aimed...
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Real-life data of Pasireotide LAR in acromegaly: a long-term follow-up
ObjectivePasireotide LAR (PAS-LAR) was released in Italy in 2017 to treat acromegaly patients resistant to SRLs (Somatostatin Receptors Ligands). The...
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Anti-aging Effects of Tirbanibulin 1% Ointment: A Real-Life Experience
IntroductionTirbanibulin 1% ointment has been licensed to treat non-hyperkeratotic actinic keratosis (AKs) on the face and scalp in adults to ensure...
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Long-term pasireotide therapy in acromegaly: extensive real-life experience of a referral center
PurposePasireotide is a novel therapeutic option for patients with acromegaly resistant to first-generation somatostatin receptor ligands. To date,...
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Predictors of change in asthma-related quality of life: a longitudinal real-life study in adult asthmatics
PurposeAsthma negatively impacts health-related quality of life (HRQL). The objective is to investigate the longitudinal relationship between HRQL in...
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Real life data: follow-up assessment on Spanish Gaucher disease patients treated with eliglustat. TRAZELGA project
BackgroundThe availability of multiple treatments for type 1 Gaucher disease increases the need for real-life studies to evaluate treatment efficacy...
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Efficacy and safety of dupilumab in the treatment of CRSwNP in the real-life setting: a review of the literature
IntroductionThe recent approval of Dupilumab has profoundly revolutionized the management of patients affected by severe and recalcitrant Chronic...
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Safety of Subcutaneous Daratumumab in Anti-CD38 Monoclonal Antibody-Naïve Patients with Plasma Cell Disorders: A Multicenter Real-Life Experience
BackgroundDaratumumab, an anti-CD38 monoclonal antibody, is used for treatment of multiple myeloma (MM) and light chain amyloidosis at an intravenous...
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A physiologically-based digital twin for alcohol consumption—predicting real-life drinking responses and long-term plasma PEth
Alcohol consumption is associated with a wide variety of preventable health complications and is a major risk factor for all-cause mortality in the...
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Real-life outcomes in biotypes of psychotic disorders based on neurocognitive performance
Aiming at discerning potential biotypes within the psychotic syndrome, we have recently reported the possible existence of two clusters or biotypes...
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Real-life management of patients with mild cognitive impairment: an Italian survey
BackgroundMild cognitive impairment (MCI) is a syndrome with heterogeneous underlying causes and different rates of disease progression, whose...
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Improved Quality of Life in Patients with Psoriasis Receiving Apremilast: Real-World Data from the Netherlands
IntroductionPsoriasis is a chronic inflammatory condition that can significantly impact the quality of life (QoL), regardless of the level of skin...
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The use of biologics in patients suffering from chronic rhinosinusitis with nasal polyps – a 4-year real life observation
PurposeAntibody therapy for chronic rhinosinusitis with nasal polyps (CRSwNP) has been established in Germany since 2019. With limited long-term data...
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Real-Life Effectiveness and Tolerance of Upadacitinib for Severe Atopic Dermatitis in Adolescents and Adults
IntroductionThe efficacy and safety of upadacitinib in atopic dermatitis have been defined in clinical trials, but long-term real-life experience,...
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Impact of a digital web-based asthma platform, a real-life study
BackgroundDigital health technology (DHT) is a growing area in the treatment of chronic diseases. Study results on DHT’s effect on asthma control...
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Long-term real-life outcomes of the Clareon® hydrophobic intraocular lens: the Clarte study in 191 eyes
BackgroundTo describe and analyze the real-life refractive, functional and safety outcomes of the Clareon® intraocular lens (IOL) after 3 years.
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A perspective on life-cycle health technology assessment and real-world evidence for precision oncology in Canada
Health technology assessment (HTA) can be used to make healthcare systems more equitable and efficient. Advances in precision oncology are...
