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Remote blood pressure monitoring in high risk pregnancy — study protocol for a randomised controlled trial (REMOTE CONTROL trial)
BackgroundPregnant women at high risk for develo** a hypertensive disorder of pregnancy require frequent antenatal assessments, especially of their...
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Effectiveness of structured self-evaluation of video recorded performance on peripheral intravenous catheter insertion: a randomised control trial study protocol
BackgroundClinical psychomotor skills training is a core component of undergraduate nursing education. Performing technical skills competently...
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FEEDBACK trial - A randomised control trial to investigate the effect of personalised feedback and financial incentives on reducing the incidence of road crashes
BackgroundRoad crashes continue to pose a significant threat to global health. Young drivers aged between 18 and 25 are over-represented in road...
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Pharmacist interventions to improve blood pressure control in primary care: a cluster randomised trial
BackgroundHigh blood pressure (BP) is the single largest contributor to mortality world-wide.
AimTo investigate the effectiveness of a...
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The SEE-IT Trial: emergency medical services Streaming Enabled Evaluation In Trauma: a feasibility randomised controlled trial
BackgroundUse of bystander video livestreaming from scene to Emergency Medical Services (EMS) is becoming increasingly common to aid decision making...
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Mānuka oil based ECMT-154 versus vehicle control for the topical treatment of eczema: study protocol for a randomised controlled trial in community pharmacies in Aotearoa New Zealand
BackgroundEczema is a chronic, relapsing skin condition commonly managed by emollients and topical corticosteroids. Prevalence of use and demand for...
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Role of preoperative zinc, magnesium and budesonide gargles in Postoperative Sore Throat (POST) - a randomised control trial
BackgroundPost-operative sore throat (POST) has an incidence ranging from 21 to 80%. To prevent the development of POST, several pharmacological...
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Trial Forge Guidance 4: a guideline for reporting the results of randomised Studies Within A Trial (SWATs)
BackgroundEvidence to support decisions on trial processes is minimal. One way to generate this evidence is to use a Study Within A Trial (SWAT) to...
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Housing modification for malaria control: impact of a “lethal house lure” intervention on malaria infection prevalence in a cluster randomised control trial in Côte d’Ivoire
BackgroundIn recent years, the downward trajectory of malaria transmission has slowed and, in some places, reversed. New tools are needed to further...
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Efficacy of heel lifts for mid-portion Achilles tendinopathy (the LIFT trial): study protocol for a randomised controlled trial
BackgroundMid-portion Achilles tendinopathy is a common condition, characterised by localised Achilles tendon load-related pain and dysfunction....
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Clinical statistical analysis plan for the ACCURE trial: the effect of appendectomy on the clinical course of ulcerative colitis, a randomised international multicentre trial
BackgroundThe primary treatment of ulcerative colitis (UC) is medical therapy using a standard step-up approach. An appendectomy might modulate the...
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Change in glycaemic control with structured diabetes self-management education in urban low-resource settings: multicentre randomised trial of effectiveness
BackgroundIn high-resource settings, structured diabetes self-management education is associated with improved outcomes but the evidence from...
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Challenges of conducting a randomised placebo-controlled trial of spinal surgery: the SUcceSS trial of lumbar spine decompression
Although placebo-controlled trials are considered the gold standard for evaluating the efficacy of healthcare interventions, they can be perceived to...
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SPiRIT study protocol (Shoulder Pain: Randomised trial of Injectable Treatments): a randomised feasibility and pilot study of autologous protein solution (APS) vs corticosteroids for treating subacromial shoulder pain
BackgroundThe management of subacromial shoulder pain represents a significant challenge and is typically managed through either physiotherapy, joint...
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Personalised versus standard text message prompts for increasing trial participant response to telephone follow-up: an embedded randomised controlled retention trial
BackgroundImproving retention within randomised controlled trials is important. The effectiveness of different strategies can be assessed using a...
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Nonsurgical management of hallux valgus: findings of a randomised pilot and feasibility trial
BackgroundHallux valgus is a common and disabling condition. This randomised pilot and feasibility trial aimed to determine the feasibility of...
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Randomised pilot and feasibility trial of a group intervention for men who perpetrate intimate partner violence against women
BackgroundThere is a need for robust evidence on the effectiveness and cost-effectiveness of domestic abuse perpetrator programmes in reducing...
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Cancer Precision-Prevention trial of Metformin in adults with Li Fraumeni syndrome (MILI) undergoing yearly MRI surveillance: a randomised controlled trial protocol
BackgroundLi-Fraumeni syndrome (LFS) is a rare autosomal dominant disease caused by inherited or de novo germline pathogenic variants in TP53 ....
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The Efficacy of 12-Week Progressive Home-Based Strength and Tai-Chi Exercise Snacking in Older Adults: A Mixed-Method Exploratory Randomised Control Trial
BackgroundMaintaining physical function is important for independence and frailty prevention in later life, but very few older adults meet exercise...
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The feasibility of negative pressure wound therapy versus standard dressings in paediatric hand and foot burns protocol: a pilot, single-centre, randomised control trial
IntroductionThe goal of paediatric hand and foot burn management is hypertrophic scar and/or contracture prevention. The risk of scar formation may...
