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Radiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer [11C]3MeO4AP
Background4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been...
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Step-by-step optimisation of the radiosynthesis of the brain HDAC6 radioligand [18F]FSW-100 for clinical applications
BackgroundHistone deacetylase 6 (HDAC6) is an emerging target for the treatment and diagnosis of proteinopathies. [ 18 F]FSW-100 was recently...
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Improved automated one-pot two-step radiosynthesis of (S)-[18F]FETrp, a radiotracer for PET imaging of indoleamine 2,3-dioxygenase 1 (IDO1)
Background( S )-[ 18 F]FETrp is a promising PET radiotracer for imaging IDO1 activity, one of the main enzymes involved in the tryptophan metabolism...
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Fully automated radiosynthesis of [68Ga]Ga-FAPI-46 with cyclotron produced gallium
BackgroundRadiopharmaceuticals capable of targeting the fibroblast activation protein have become widely utilized in the research realm as well as...
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Radiosynthesis and Analysis of (S)-4-(3-[18F]Fluoropropyl)-L-Glutamic Acid
Purpose( S )-4-(3-[ 18 F]Fluoropropyl)-L-glutamic acid ([ 18 F]FSPG) is an L-glutamate derivative used as a PET biomarker to assess intracellular redox...
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Advancing 6-bromo-7-[11C]methylpurine to clinical use: improved regioselective radiosynthesis, non-clinical toxicity data and human dosimetry estimates
Background6-Bromo-7-[ 11 C]methylpurine ([ 11 C]BMP) is a radiotracer for positron emission tomography (PET) to measure multidrug resistance-associated...
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Automated radiosynthesis and preclinical evaluation of two new PSMA-617 derivatives radiolabelled via [18F]AlF2+ method
BackgroundIn the last decade the development of new PSMA-ligand based radiopharmaceuticals for the imaging and therapy of prostate cancer has been a...
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Automated radiosynthesis and in vivo evaluation of 18F-labeled analog of the photosensitizer ADPM06 for planning photodynamic therapy
BackgroundA family of BF 2 -chelated tetraaryl-azadipyrromethenes was developed as non-porphyrin photosensitizers for photodynamic therapy. Among the...
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Radiosynthesis and biological evaluation of [18F]AG-120 for PET imaging of the mutant isocitrate dehydrogenase 1 in glioma
Glioma are clinically challenging tumors due to their location and invasiveness nature, which often hinder complete surgical resection. The...
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Aluminum Fluoride-18 Labeled Mannosylated Dextran: Radiosynthesis and Initial Preclinical Positron Emission Tomography Studies
PurposeIn addition to being expressed on liver sinusoidal endothelial cells, mannose receptors are also found on antigen-presenting cells, including...
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Radiosynthesis and Evaluation of a C-11 Radiotracer for Transient Receptor Potential Canonical 5 in the Brain
PurposeTRPC5 belongs to the mammalian superfamily of transient receptor potential (TRP) Ca 2+ -permeable cationic channels and it has been implicated...
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Radiosynthesis and preclinical evaluation of [11C]SNX-ab as an Hsp90α,β isoform-selective PET probe for in vivo brain and tumour imaging
BackgroundThe molecular chaperone, Hsp90, is a key player in the protein quality control system that maintains homeostasis under cellular stress...
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Optimization and scale up of production of the PSMA imaging agent [18F]AlF-P16-093 on a custom automated radiosynthesis platform
BackgroundRecent advancements in positron emission tomograph (PET) using prostate specific membrane antigen (PSMA)-targeted radiopharmaceuticals have...
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Robust and Facile Automated Radiosynthesis of [18F]FSPG on the GE FASTlab
Purpose(S)-4-(3- 18 F-Fluoropropyl)-ʟ-Glutamic Acid ([ 18 F]FSPG) is a radiolabeled non-natural amino acid that is used for positron emission tomography...
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Radiosynthesis, structural identification and in vitro tissue binding study of [18F]FNA-S-ACooP, a novel radiopeptide for targeted PET imaging of fatty acid binding protein 3
BackgroundFatty acid binding protein 3 (FABP3) is a target with clinical relevance and the peptide ligand ACooP has been identified for FABP3...
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A practical fully automated radiosynthesis of [18F]Flurpiridaz on the module modular lab-pharmtracer without external purification
Background[ 18 F]Flurpiridaz is a promising novel cardiac PET imaging tracer formed by the radiolabeling of pyridaben derivative with fluorine-18....
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GMP-compliant fully automated radiosynthesis of [18F]FEPPA for PET/MRI imaging of regional brain TSPO expression
BackgroundExpression of translocator protein (TSPO) on the outer mitochondrial membrane of activated microglia is strongly associated with...
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Optimized, automated and cGMP-compliant synthesis of the HER2 targeting [68Ga]Ga-ABY-025 tracer
BackgroundThe Affibody molecule, ABY-025, has demonstrated utility to detect human epidermal growth factor receptor 2 (HER2) in vivo, either...
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Fully automated radiosynthesis of [18F]LBT999 on TRACERlab FXFN and AllinOne modules, a PET radiopharmaceutical for imaging the dopamine transporter in human brain
BackgroundFluorine labelled 8-(( E )-4-fluoro-but-2-enyl)-3β- p -tolyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ([ 18 F]LBT999) is a...
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Synthesis of [18F]FMISO, a hypoxia-specific imaging probe for PET, an overview from a radiochemist’s perspective
Background[ 18 F]fluoromisonidazole ([ 18 F]FMISO, 1 H -1-(3-[ 18 F]fluoro-2-hydroxypropyl)-2-nitroimidazole) is a commonly used radiotracer for imaging...
