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Use of imaging-based dosimetry for personalising radiopharmaceutical therapy of cancer
Theranostics – i.e., the combination of molecular imaging and radiopharmaceutical therapy of cancer targeting a common biological feature – is a...
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Imaging and dosimetry for alpha-particle emitter radiopharmaceutical therapy: improving radiopharmaceutical therapy by looking into the black box
Radiopharmaceutical therapy using α-particle emitting radionuclides (αRPT) is a novel treatment modality that delivers highly potent alpha-particles...
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MIB Guides: Preclinical Radiopharmaceutical Dosimetry
Preclinical dosimetry is essential for guiding the design of animal radiopharmaceutical biodistribution, imaging, and therapy experiments, evaluating...
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Deep transformer-based personalized dosimetry from SPECT/CT images: a hybrid approach for [177Lu]Lu-DOTATATE radiopharmaceutical therapy
PurposeAccurate dosimetry is critical for ensuring the safety and efficacy of radiopharmaceutical therapies. In current clinical dosimetry practice,...
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Can current preclinical strategies for radiopharmaceutical development meet the needs of targeted alpha therapy?
Preclinical studies are essential for effectively evaluating TAT radiopharmaceuticals. Given the current suboptimal supply chain of these...
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Pre-therapy PET-based voxel-wise dosimetry prediction by characterizing intra-organ heterogeneity in PSMA-directed radiopharmaceutical theranostics
Background and objectiveTreatment planning through the diagnostic dimension of theranostics provides insights into predicting the absorbed dose of...
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Bacterial survival in radiopharmaceutical solutions: a critical impact on current practices
BackgroundThe aim of this brief communication is to highlight the potential bacteriological risk linked to the processes control of...
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Impact of the dead-time correction method on quantitative 177Lu-SPECT (QSPECT) and dosimetry during radiopharmaceutical therapy
BackgroundDead-time correction is required for accurate quantitative SPECT-based dosimetry in the context of personalised 177 Lu radiopharmaceutical...
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Anti-GD2 antibody for radiopharmaceutical imaging of osteosarcoma
PurposeOsteosarcoma (OS) is the most frequently diagnosed bone cancer in children with little improvement in overall survival in the past decades....
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Current Status of PSMA-Targeted Radioligand Therapy in the Era of Radiopharmaceutical Therapy Acquiring Marketing Authorization
Prostate-specific membrane antigen (PSMA) is highly expressed in PCa, which gradually increases in high-grade tumors, metastatic tumors, and tumors...
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Good practices for 68Ga radiopharmaceutical production
BackgroundThe radiometal gallium-68 ( 68 Ga) is increasingly used in diagnostic positron emission tomography (PET), with 68 Ga-labeled...
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KSNM60: The History of Radiopharmaceutical Sciences in Korea
A number of researchers in Korea have tried to set-up the production of radionuclides and develop new radiopharmaceuticals for several decades....
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Estimation of relative biological effectiveness of 225Ac compared to 177Lu during [225Ac]Ac-PSMA and [177Lu]Lu-PSMA radiopharmaceutical therapy using TOPAS/TOPAS-nBio/MEDRAS
AimOver recent years, [ 225 Ac]Ac-PSMA and [ 177 Lu]Lu-PSMA radiopharmaceutical therapy have evolved as a promising treatment option for advanced...
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Voxel-Based Internal Dosimetry for 177Lu-Labeled Radiopharmaceutical Therapy Using Deep Residual Learning
PurposeIn this study, we propose a deep learning (DL)–based voxel-based dosimetry method in which dose maps acquired using the multiple voxel S-value...
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Impact of radiopharmaceutical therapy (177Lu, 225Ac) microdistribution in a cancer-associated fibroblasts model
BackgroundThe aim of this study is to elucidate the difference in absorbed dose (D abs ) patterns in radiopharmaceutical therapies between alpha...
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Dosimetric impact of Ac-227 in accelerator-produced Ac-225 for alpha-emitter radiopharmaceutical therapy of patients with hematological malignancies: a pharmacokinetic modeling analysis
BackgroundActinium-225 is an alpha-particle emitter under investigation for use in radiopharmaceutical therapy. To address limited supply,...
