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Effects and mechanisms of puerarin against neuroblastoma: insights from bioinformatics and in vitro experiments
BackgroundNeuroblastoma, a prevalent solid tumor in children, often manifests with hidden onset sites, rapid growth, and high metastatic potential....
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Puerarin attenuates valproate-induced features of ASD in male mice via regulating Slc7a11-dependent ferroptosis
Autism spectrum disorder (ASD) is a complicated, neurodevelopmental disorder characterized by social deficits and stereotyped behaviors. Accumulating...
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Metabolomic and microbiome analysis of the protective effects of Puerarin against Salmonella Enteritidis Infection in chicks
BackgroundSalmonella Enteritidis is a zoonotic pathogen and poses a substantial risk to human health, as well as significant financial losses to the...
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Puerarin protects fibroblasts against mechanical stretching injury through Nrf2/TGF-β1 signaling pathway
Introduction and hypothesisStress urinary incontinence (SUI) is the most common form of urinary incontinence in women, which affects women’s quality...
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Puerarin prevents calcium oxalate crystal-induced renal epithelial cell autophagy by activating the SIRT1-mediated signaling pathway
Calcium oxalate (CaOx) crystals can activate autophagy, causing damage to renal tubular epithelial cells (TECs). Puerarin has been shown to have...
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Exploring the mechanism and experimental verification of puerarin in the treatment of endometrial carcinoma based on network pharmacology and bioinformatics analysis
Endometrial carcinoma is one of the two cancers with rising mortality and morbidity in recent years. In the light of many controversies about its...
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Ameliorated biomechanical properties of carotid arteries by puerarin in spontaneously hypertensive rats
BackgroundAn emerging body of evidence indicates that puerarin (PUE) plays an important role in the treatment of angina pectoris, myocardial...
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Tailoring enhanced production and identification of isoflavones in the callus cultures of Pueraria thomsonii Benth and its model verification using response surface methodology (RSM): a combined in vitro and statistical optimization
BackgroundScientifically, isoflavones from Pueraria thomsonii Benth possess diverse pharmacological activities and have been used to treat various...
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Puerarin inhibits the osteoclastogenesis by inhibiting RANKL-dependent and –independent autophagic responses
BackgroundPuerarin exerts therapeutic effect on osteoporosis due to its inhibitory effect on the formation of osteoclasts. Puerarin is also widely...
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Protective Effects of Puerarin on Premature Ovarian Failure via Regulation of Wnt/β-catenin Signaling Pathway and Oxidative Stress
This study was designed to investigate the protective effects of puerarin (PUE), which work via the Wnt/β-catenin signaling pathway, and oxidative...
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Optimization of the extraction process for Shenshou Taiyi powder based on Box-Behnken experimental design, standard relation, and FAHP-CRITIC methods
BackgroundAncient classic prescription play a crucial role in the preservation and advancement of traditional Chinese medicine (TCM) theories. They...
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Screening and verification of antiviral compounds against HSV-1 using a method based on a plaque inhibition assay
BackgroundHerpes simplex virus type 1 (HSV-1) infection is a common viral disease that mainly causes oral lesions, but can also cause genital lesions...
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Age-related hearing loss and its potential drug candidates: a systematic review
BackgroundAge-related hearing loss (ARHL) is one of the main illnesses afflicting the aged population and has a significant negative impact on...
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Natural L-type calcium channels antagonists from Chinese medicine
L-type calcium channels (LTCCs), the largest subfamily of voltage-gated calcium channels (VGCCs), are the main channels for Ca 2+ influx during...
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Mechanisms and efficacy of traditional Chinese herb monomers in diabetic kidney disease
Diabetic kidney disease (DKD) is a serious complication of diabetes and is the primary cause of end-stage renal disease. Current treatment strategies...
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Simultaneous quantification of bioactive components in Chinese herbal spirits by ultra-high performance liquid chromatography coupled to triple-quadrupole mass spectrometry (UHPLC–QQQ–MS/MS)
BackgroundThe Chinese medicinal wine made from herbal medicines became prevalent among Chinese people. The Chinese herbal spirit is composed of...
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Danlou Recipe promotes cholesterol efflux in macrophages RAW264.7 and reverses cholesterol transport in mice with hyperlipidemia induced by P407
IntroductionLiver X Receptor (LXR) agonists could attenuate the development of atherosclerosis but bring excess lipid accumulation in the liver....
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Gegen Qinlian decoction (GQD) inhibits ulcerative colitis by modulating ferroptosis-dependent pathway in mice and organoids
BackgroundGegen Qinlian decoction (GQD) is a classic prescription for treating ulcerative colitis (UC) in traditional Chinese medicine. However, the...
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A comprehensive review comparing conventional versus traditional remedies in the treatment of endometriosis with futuristic insights
BackgroundA common condition known as endometriosis typically takes place in females in their reproductive age and develops generally in the...
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Comparison of the efficacy and safety of Shanhuang Jiangzhi tablets and atorvastatin in the treatment of patients with hyperlipidaemia
ObjectivesTo compare the efficacy and safety of Shanhuang Jiangzhi tablets and atorvastatin in reducing blood lipid levels.
MethodsPatients with...