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Protective potential of pterostilbene against cyclophosphamide-induced nephrotoxicity and cystitis in rats
PurposeCyclophosphamide (CYP) is an antitumor drug. However, in addition to its antitumor affect, CYP can also lead to nephrotoxicity and hemorrhagic...
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Pterostilbene alleviates pulmonary fibrosis by regulating ASIC2
BackgroundIdiopathic pulmonary fibrosis (IPF) is a serious chronic disease of the respiratory system, but its current treatment has certain...
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Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI
BackgroundPreclinical studies have identified both NAD + and sirtuin augmentation as potential strategies for the prevention and treatment of AKI....
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Serum metabolites of hypertension among Chinese adolescents aged 12–17 years
The regulatory mechanisms of hypertension in youth are incompletely understood. We aimed to identify potential serum metabolic alterations associated...
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Diabetes-induced auditory complications: are they preventable? a comprehensive review of interventions
Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels, which, over time, lead to major chronic...
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Liver cancer wars: plant-derived polyphenols strike back
Liver cancer currently represents the leading cause of cancer-related death worldwide. The majority of liver cancer arises in the context of chronic...
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Greasing the Wheels of Pharmacotherapy for Colorectal Cancer: the Role of Natural Polyphenols
Purpose of ReviewThe main purpose of this review, mainly based on preclinical studies, is to summarize the pharmacological and biochemical evidence...
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Isorhapontigenin ameliorates high glucose-induced podocyte and vascular endothelial cell injuries via mitigating oxidative stress and autophagy through the AMPK/Nrf2 pathway
BackgroundDiabetic nephropathy (DN) is a severe microvascular complication of diabetes mellitus and a primary reason for end-stage renal disease...
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Resveratrol effects in oral cancer cells: a comprehensive review
Oral cancer is a very common tumor worldwide with high incidence and mortality. The treatment of oral cancer involves surgery, radio- and...
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Pterostilbene Decreases Cardiac Oxidative Stress and Inflammation via Activation of AMPK/Nrf2/HO-1 Pathway in Fructose-Fed Diabetic Rats
PurposeOxidative stress has a pivotal role in the pathogenesis of diabetes-associated cardiovascular problems, which has remained a primary cause of...
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Natural Sirtuin1 Activators and Atherosclerosis: an Overview
Purpose of ReviewThe purpose of this review is to summarize the most recent findings investigating the impact of several natural sirtuin (SIRT)...
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Inhibitory effect of polyphenols (phenolic acids, lignans, and stilbenes) on cancer by regulating signal transduction pathways: a review
Natural products, especially polyphenols (phenolic acids, lignans, and stilbenes) are suggested to be more potent anticancer drugs because of their...
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The recent update and advancements of natural products in targeting the Wnt/β-Catenin pathway for cancer prevention and therapeutics
The Wnt/β-Catenin pathway (Wnt/β-CatP) is implicated in accelerating carcinogenesis and cancer progression, contributing to increased morbidity and...
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Hair Follicle Melanocytes Initiate Autoimmunity in Alopecia Areata: a Trigger Point
Alopecia areata (AA) is characterized by common non-scarring alopecia due to autoimmune disorders. To date, the specific pathogenesis underlying AA...
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A systematic review of the research progress of traditional Chinese medicine against pulmonary fibrosis: from a pharmacological perspective
Pulmonary fibrosis is a chronic progressive interstitial lung disease caused by a variety of etiologies. The disease can eventually lead to...
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Finding New Targets for the Treatment of Heart Failure: Endoplasmic Reticulum Stress and Autophagy
AbstractHeart failure is a progressive disease with an annual mortality rate of about 10% and is the end-stage stage of various heart diseases, which...
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Plant bioactive compounds and their mechanistic approaches in the treatment of diabetes: a review
BackgroundDiabetes mellitus (DM) is a growing disease across the world; diabetes is a complex metabolic disorder in which blood glucose concentration...
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Kuanxiong Aerosol (宽胸气雾剂) in Treatment of Angina Pectoris: A Literature Review and Network Pharmacology
Angina pectoris (AP) is the most common symptom of cardiovascular diseases, which seriously affects the quality of life in cardiovascular patients....
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Comprehensive review of the repositioning of non-oncologic drugs for cancer immunotherapy
Drug repositioning or repurposing has gained worldwide attention as a plausible way to search for novel molecules for the treatment of particular...
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Pterostilbene protects against uraemia serum-induced endothelial cell damage via activation of Keap1/Nrf2/HO-1 signaling
Chronic kidney disease causes uremia-related endothelial cell dysfunction associated with high risk for cardiovascular diseases. The vascular...
