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Therapeutic mechanisms of psychedelics and entactogens
Recent clinical and preclinical evidence suggests that psychedelics and entactogens may produce both rapid and sustained therapeutic effects across...
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Psychedelics for acquired brain injury: a review of molecular mechanisms and therapeutic potential
Acquired brain injury (ABI), such as traumatic brain injury and stroke, is a leading cause of disability worldwide, resulting in debilitating acute...
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Are “mystical experiences” essential for antidepressant actions of ketamine and the classic psychedelics?
The growing interest in the rapid and sustained antidepressant effects of the dissociative anesthetic ketamine and classic psychedelics, such as...
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Neurobiology of the Antidepressant Effects of Serotonergic Psychedelics: A Narrative Review
Purpose of ReviewSerotonergic psychedelics include psilocybin, lysergic acid diethylamide (LSD), dimethyltryptamine (DMT), and other agonists of the...
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Mechanisms and molecular targets surrounding the potential therapeutic effects of psychedelics
Psychedelics, also known as classical hallucinogens, have been investigated for decades due to their potential therapeutic effects in the treatment...
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Psychedelics and Racial Justice
Psychedelics are being studied for the treatment of numerous mental health disorders, as well as a means of bringing people together. Nonetheless,...
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The Potential of Psychedelics for the Treatment of Episodic Migraine
Purpose of ReviewThis review presents the existing literature of and a framework for how psychedelic drugs might be applied as therapeutic agents in...
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The Therapeutic Effects of Classic Psychedelics in Alcohol Use Disorder
Purpose of reviewThis article utilizes a pre-existing framework in the field of addiction to comprehensively capture the effects of classic...
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Psychedelics: preclinical insights provide directions for future research
Recently, psychedelics have emerged as promising therapeutics for numerous neuropsychiatric disorders. While their potential in the clinic has yet to...
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Epigenetic drugs and psychedelics as emerging therapies for alcohol use disorder: insights from preclinical studies
Alcohol use disorder (AUD) is a public health issue that affects millions of people worldwide leading to physical, mental and socio-economic...
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Psychotherapeutic Interventions in Clinical Trials of Psychedelics for the Treatment of Alcohol Use Disorder
Purpose of ReviewAlcohol use disorder (AUD) is the most common substance use disorder in the USA, with a considerable burden of disease. In recent...
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Muslim Women and Psychedelics: a Look at the Past, Present, and Future
The Qur’an prohibits the use of intoxicants such as alcohol. However, the use of psychedelics falls somewhere in between social acceptance and...
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Decision-Making around Psychedelics for Depression and Anxiety: a Model Based on Online Discussions
Little is known about how people decide to use psychedelics to self-treat depression and anxiety, though the practice is growing. We explored online...
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Psychedelics in the treatment of unipolar and bipolar depression
This is a narrative review about the role of classic and two atypical psychedelics in the treatment of unipolar and bipolar depression. Since the...
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The Potential for Psychedelics to Improve Co** Skills and Resilience in Persons With Newly Diagnosed Mild Cognitive Impairment or Early Alzheimer’s Disease
Purpose of ReviewMild Cognitive Impairment and mild Alzheimer’s disease are associated with depression and existential distress, but high quality...
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Comparing Substance Use Consequences between Serotonergic Psychedelics, MDMA, and other Drugs of Abuse Among United States Adults with History of Psychiatric Illness
Psychedelic-assisted therapy could transform treating psychiatric illness, but harms from exacerbating substance use disorder (SUD) among adults with...
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Sustained effects of single doses of classical psychedelics in humans
The serotonergic classical psychedelics include compounds that primarily activate the brain’s serotonin 2 A receptor (5-HT2AR), such as LSD,...
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Experiences of microdosing psychedelics in an attempt to support wellbeing and mental health
BackgroundMicrodosing psychedelic drugs is a growing phenomenon, but little is known about the experiences surrounding this. Research broadly...
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Antidepressant-like effects of psychedelics in a chronic despair mouse model: is the 5-HT2A receptor the unique player?
Major depressive disorder (MDD) is one of the most disabling psychiatric disorders in the world. First-line treatments such as selective serotonin...
