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Predictors of Psoriasis Area and Severity Index 100 response in Korean patients with moderate-to-severe plaque psoriasis receiving biologics
BackgroundThe Psoriasis Area and Severity Index (PASI) 100 response rate after treatment with biologics is reportedly lower in Asians than...
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Redefining Disease Severity with Special Area Involvement and Reflecting on Treatment Patterns in a Real-World Psoriasis Population
BackgroundThe International Psoriasis Council (IPC) recommends an approach that considers body surface area (BSA), involvement in special areas, and...
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Ixekizumab Demonstrates Rapid and Consistent Efficacy for Patients with Psoriatic Arthritis, Regardless of Psoriasis Severity
IntroductionSkin involvement in patients with psoriatic arthritis (PsA) worsens the severity and burden of disease. Ixekizumab (IXE), a selective...
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Evaluation of the inflammatory parameters as potential biomarkers of systemic inflammation extent and the disease severity in psoriasis patients
The disease severity of psoriasis is mainly assessed subjectively via psoriasis area and severity index (PASI) and body surface area (BSA), while an...
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Consistent Efficacy of Apremilast in Patients with Psoriasis Regardless of Baseline Disease Severity or Special Area Involvement: Subgroup Analysis from PROMINENT
IntroductionPsoriasis involvement in special areas (e.g., scalp or nails) is associated with a great disease burden yet it is often inadequately...
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Telemedicine in Nail Psoriasis: Validation of a New Tool to Monitor (In-Person, In-Picture, and In-Video) Nail Psoriasis Severity in Patients with Concurrent Onychophagia and Onychotillomania
IntroductionSince during the COVID-19 pandemic nail psoriasis was evaluated exclusively with teledermatology, dermatologists started to face the...
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Effectiveness of Ixekizumab in Chinese Patients with Moderate-Severe Plaque Psoriasis with Special Area Involvement: Subanalysis of a Prospective, Multicenter, Observational Real-World Study
IntroductionIxekizumab, a monoclonal antibody against interleukin-17A, demonstrated effectiveness in the treatment of psoriasis in a Chinese...
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Correlation Between Change in Psoriasis Area and Severity Index and Dermatology Life Quality Index in Patients with Psoriasis: Pooled Analysis from Four Phase 3 Clinical Trials of Secukinumab
IntroductionPatients with psoriasis (PsO) experience impaired health-related quality of life due to physical and psychosocial burdens. The objective...
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Development and internal validation of a diagnostic prediction model for psoriasis severity
BackgroundWhile administrative health records such as national registries may be useful data sources to study the epidemiology of psoriasis, they do...
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The association between platelet indices and presence and severity of psoriasis: a systematic review and meta-analysis
The role of platelet function indices—platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT),...
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Validation and application of the Dermatology Life Quality Index score, a modification of the DLQI score, in psoriasis patients
BackgroundAll the scoring methods for the DLQI miss the moderate impact of the disease on patients, which may underestimate the impact of psoriasis...
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Baseline Characteristics and mNAPSI Change from Baseline Scores Through Month 12 for Patients with Moderate-to-Severe Plaque Psoriasis and Concomitant Nail Psoriasis Treated with Biologics from PSoHO
IntroductionNail psoriasis is highly prevalent among patients with psoriasis yet remains one of the most challenging areas to treat. To better...
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Associations of novel complete blood count-derived inflammatory markers with psoriasis: a systematic review and meta-analysis
Psoriasis is an immune-mediated disorder which primarily affects skin and has systemic inflammatory involvement. Neutrophil-to-lymphocyte ratio...
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Psychosocial Burden of Psoriasis: A Systematic Literature Review of Depression Among Patients with Psoriasis
Psoriasis is associated with various comorbidities with a notable psychosocial burden. This systematic literature review explores the burden of...
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The Proposed PASI-HD Provides More Precise Assessment of Plaque Psoriasis Severity in Anatomical Regions with a Low Area Score
The Psoriasis Area and Severity Index (PASI) is the most widely used clinical measure in clinical trials to assess disease severity of plaque...
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Durability of Near-Complete Skin Clearance in Patients with Psoriasis Using Systemic Biologic Therapies: Real-World Evidence from the CorEvitas Psoriasis Registry
IntroductionNear-complete skin clearance has become a rapidly achievable treatment goal for patients with psoriasis receiving systemic biologic...
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Plexin B2 tissue expression and related gene polymorphisms in psoriasis and their relation to NB-UVB and Acitretin therapy
Psoriasis is a chronic, immune-mediated, hyperproliferative skin disease. Etiopathogenesis of psoriasis is not well understood. Plexin B2 was found...
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Effectiveness of secukinumab in patients with psoriasis and psoriatic arthritis in a Saudi real-world setting
IntroductionPsoriasis (PsO) is an immune-mediated chronic inflammatory disease that results in severe outcomes that impact the patient’s quality of...
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Long-Term Effectiveness and Safety of Ixekizumab for the Treatment of Moderate-to-Severe Plaque Psoriasis: A Five-Year Multicenter Retrospective Study—IL PSO (Italian Landscape Psoriasis)
IntroductionThe introduction of biological therapies has revolutionized the treatment of moderate-to-severe plaque psoriasis. In particular,...
