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Comparison of passive-scattered and intensity-modulated proton beam therapy of craniospinal irradiation with proton beams for pediatric and young adult patients with brain tumors
PurposeTo investigate the dose stability of craniospinal irradiation based on irradiation method of proton beam therapy (PBT).
Methods and materials ...
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Craniospinal irradiation for CNS leukemia: rates of response and durability of CNS control
PurposeManagement of CNS involvement in leukemia may include craniospinal irradiation (CSI), though data on CSI efficacy are limited.
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High dose craniospinal irradiation as independent risk factor of permanent alopecia in childhood medulloblastoma survivors: cohort study and literature review
PurposeOur aim was to determine the main risk factors related to the occurrence of permanent alopecia in childhood medulloblastoma (MB) survivors.
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Impact of spot positional errors in robustly optimized intensity-modulated proton therapy plan of craniospinal irradiation
We investigated the influence of random spot positioning errors (SPEs) on dosimetric outcomes of robustly optimized intensity-modulated proton...
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A systematic review of craniospinal irradiation for leptomeningeal disease: past, present, and future
PurposeLeptomeningeal disease (LMD) is a rare but deadly complication of cancer in which the disease spreads to the cerebrospinal fluid and seeds the...
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Pretreatment central quality control for craniospinal irradiation in non-metastatic medulloblastoma
PurposeSeveral studies have demonstrated the negative impact of radiotherapy protocol deviations on tumor control in medulloblastoma. In the SIOP...
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Echocardiographic myocardial strain analysis describes subclinical cardiac dysfunction after craniospinal irradiation in pediatric and young adult patients with central nervous system tumors
BackgroundCraniospinal irradiation (CSI) is part of the treatment of central nervous system (CNS) tumors and is associated with cardiovascular...
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Critical Appraisal of Proton Therapy for Patients with Central Nervous System (CNS) Malignancies
As more hospital-based proton treatment centres become operational, the indications for proton beam therapy (PBT) are being evaluated. Recent...
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Radiotherapy for Atypical Teratoid/Rhabdoid Tumor (ATRT) on the Pediatric Proton/Photon Consortium Registry (PPCR)
PurposeAtypical teratoid/rhabdoid tumors (ATRT) of the central nervous system (CNS) are rare tumors with a poor prognosis and variable use of either...
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Hospital-based proton therapy implementation during the COVID pandemic: early clinical and research experience in a European academic institution
IntroductionA rapid deploy of unexpected early impact of the COVID pandemic in Spain was described in 2020. Oncology practice was revised to...
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Mitigating Radiotoxicity in the Central Nervous System: Role of Proton Therapy
Central nervous system (CNS) radiotoxicity remains a challenge in neuro-oncology. Dose distribution advantages of protons over photons have prompted...
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Proton therapy for adult medulloblastoma: Acute toxicity and disease control outcomes
PurposeWe report disease control, survival outcomes, and treatment-related toxicity among adult medulloblastoma patients who received proton...
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Neurocognitive outcomes in pediatric brain tumors after treatment with proton versus photon radiation: a systematic review and meta-analysis
BackgroundAdvances in cancer treatments, particularly the development of radiation therapy, have led to improvements in survival outcomes in children...
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Comparison of hypothyroidism, growth hormone deficiency, and adrenal insufficiency following proton and photon radiotherapy in children with medulloblastoma
BackgroundEndocrine deficiencies are common following Craniospinal irradiation (CSI) in children with brain tumors, but empirical data comparing...
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Quality of life in survivors of pediatric medulloblastoma: a systematic review and meta-analysis
IntroductionMedulloblastoma (MB) is the most common malignant pediatric brain tumor. The mainstay of treatment is maximum surgical resection and...
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Pediatric pituitary adenoma and medulloblastoma in the setting of p53 mutation: case report and review of the literature
Li-Fraumeni syndrome is a cancer predisposition condition associated with various tumor types. We present the case of a 6-year-old boy who initially...
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DEGRO guideline for personalized radiotherapy of brain metastases and leptomeningeal carcinomatosis in patients with breast cancer
PurposeThe aim of this review was to evaluate the existing evidence for radiotherapy for brain metastases in breast cancer patients and provide...
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The effectiveness and safety of proton beam radiation therapy in children and young adults with Central Nervous System (CNS) tumours: a systematic review
BackgroundCentral nervous system (CNS) tumours account for around 25% of childhood neoplasms. With multi-modal therapy, 5-year survival is at around...
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Knowledge and competences in hematological malignancies amongst radiation oncology residents in Germany—results from a national survey
IntroductionRadiation oncology is a pivotal modality in the treatment of hematologic malignancies. To enable state-of-the-art patient care,...
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Neurocognitive impairment following proton therapy for paediatric brain tumour: a systematic review of post-therapy assessments
BackgroundProton therapy (PT), frequently utilised to treat paediatric brain tumour (PBT) patients, eliminates exit dose and minimises dose to...
