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Multiplatform tear proteomic profiling reveals novel non-invasive biomarkers for diabetic retinopathy
ObjectivesTo investigate a comprehensive proteomic profile of the tear fluid in patients with diabetic retinopathy (DR) and further define...
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Longitudinal plasma proteomic analysis identifies biomarkers and combinational targets for anti-PD1-resistant cancer patients
The response rate of anti-PD1 therapy is limited, and the influence of anti-PD1 therapy on cancer patients is unclear. To address these challenges,...
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Proteomic biomarkers for survival in systemic sclerosis-associated pulmonary hypertension
BackgroundInterstitial lung disease (ILD) and pulmonary hypertension (PH) represent the major causes of mortality in systemic sclerosis (SSc)....
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Targeted single-cell proteomic analysis identifies new liquid biopsy biomarkers associated with multiple myeloma
Multiple myeloma (MM) is accompanied by alterations to the normal plasma cell (PC) proteome, leading to changes to the tumor microenvironment and...
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Proteomic analysis of exosomes secreted during the epithelial-mesenchymal transition and potential biomarkers of mesenchymal high-grade serous ovarian carcinoma
BackgroundThe epithelial-mesenchymal transition (EMT) promotes cell signaling and morphology alterations, contributing to cancer progression....
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Proteomic characterization of esophageal squamous cell carcinoma response to immunotherapy reveals potential therapeutic strategy and predictive biomarkers
Immunotherapy is the first-line therapy for esophageal squamous cell carcinoma (ESCC), yet many patients do not respond due to drug resistance and...
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Proteomic analysis discovers potential biomarkers of early traumatic axonal injury in the brainstem
ObjectiveApplication of Tandem Mass Tags (TMT)-based LC–MS/MS analysis to screen for differentially expressed proteins (DEPs) in traumatic axonal...
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Quantitative proteomic screening uncovers candidate diagnostic and monitoring serum biomarkers of ankylosing spondylitis
BackgroundWe sought to discover serum biomarkers of ankylosing spondylitis (AS) for diagnosis and monitoring disease activity.
Methods ...
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Integrated proteomic and genomic analysis to identify predictive biomarkers for valproate response in bipolar disorder: a 6-month follow-up study
BackgroundSeveral genetic studies have been undertaken to elucidate the intricate interplay between genetics and drug responses in bipolar disorder...
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Current look at the most promising proteomic and glycomic biomarkers of bladder cancer
BackgroundBladder cancer (BC) belongs to the most frequent cancer types. The diagnostic process is still long and costly, with a high percentage of...
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A systematic proteomic profiling and pathway analysis of protein biomarkers in diabetic retinopathy with subsequent validation of the IL-6 upstream regulator
PurposeDiabetic retinopathy (DR) is a leading cause of irreversible blindness worldwide. Identifying risk factors associated with DR development and...
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Proteomic analysis of cardiometabolic biomarkers and predictive modeling of severe outcomes in patients hospitalized with COVID-19
BackgroundThe high heterogeneity in the symptoms and severity of COVID-19 makes it challenging to identify high-risk patients early in the disease....
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Proteomic Biomarkers of Intrahepatic Cholestasis of Pregnancy
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease, which can lead to adverse fetal outcomes, including preterm labor...
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Proteomic analysis investigating kidney transplantation outcomes- a sco** review
BackgroundKidney transplantation is the optimal treatment option for most patients with end-stage kidney disease given the significantly lower...
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A Proteomic Analysis of Human Follicular Fluid: Proteomic Profile Associated with Embryo Quality
Embryo selection is a key point of in vitro fertilization (IVF). The most commonly used method for embryo selection is morphological assessment....
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Identification of the immune-related biomarkers in Behcet’s disease by plasma proteomic analysis
BackgroundThis study aimed to investigate the expression profile of immune response-related proteins of Behcet’s disease (BD) patients and identify...
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Cord Blood Proteomic Biomarkers for Predicting Adverse Neurodevelopmental Outcomes in Monoamniotic Twins
Monoamniotic twins have a high risk of mortality and perinatal morbidity due to cord entanglement and vascular anastomosis. Despite efforts to reduce...
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Ventricular CSF proteomic profiles and predictors of surgical treatment outcome in chronic hydrocephalus
BackgroundBy applying an unbiased proteomic approach, we aimed to search for cerebrospinal fluid (CSF) protein biomarkers distinguishing between...
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Plasma Proteomic Analysis Based on 4D-DIA Evaluates the Clinical Response to Imrecoxib in the Early Treatment of Osteoarthritis
IntroductionNonsteroidal anti-inflammatory drugs (NSAIDs) are the primary treatment for osteoarthritis (OA), but prolonged use has adverse effects...
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Protein profiling in systemic sclerosis patients with different pulmonary complications using proteomic antibody microarray
BackgroundPulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) are leading causes of systemic sclerosis (SSc)-related death. In...
