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Circ_0000705 facilitates proline metabolism of esophageal squamous cell carcinoma cells by targeting miR-621/PYCR1 axis
CircRNAs have been found to play crucial roles in the metabolism and progression of cancers, but their roles and mechanisms in esophageal squamous...
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Enhanced systematic delivery of fluconazole-loaded biotin-glutathione functionalized chitosan-g-proline carrier into the infected retinitis treatment
BackgroundThe polymer-based facile and effective drug carrier approach was developed to treat superficial fungal infected retinopathy infections.
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Proline-Rich Protein 11 Overexpression in Invasive Breast Carcinoma: A Potential Diagnosis Biomarker
PurposeThis study aims to investigated the expression of proline-rich protein 11 (PRR11) as a diagnostic biomarker of invasive breast cancer and to...
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The C-terminal proline-rich repeats of Enteropathogenic E. coli effector EspF are sufficient for the depletion of tight junction membrane proteins and interactions with early and recycling endosomes
BackgroundEnteropathogenic E. coli (EPEC) causes acute infantile diarrhea accounting for significant morbidity and mortality in develo**...
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Promising role of topical caffeine mesoporous gel in collagen resynthesis and UV protection through proline assessment
BackgroundCaffeine, an alkaloid agent, has been globally used regularly in drinks, for the reduction in skin cancers and wrinkle formation. As a...
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Hyaluronic Acid Fillers Enriched with Glycine and Proline in Eyebrow Augmentation Procedure
BackgroundThe eyebrow area is a clinically critical district due to the anatomical complexity and the propensity to aging-related atrophy. Hyaluronic...
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Value of Proline, Glutamic Acid, and Leucine-Rich Protein 1 and GATA Binding Protein 3 Expression in Breast Cancer: An Immunohistochemical study
GATA binding protein 3 was more sensitive than traditional markers such as gross cystic disease fluid protein 15 and mammaglobin for identifying...
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Cancer progression is mediated by proline catabolism in non-small cell lung cancer
Dysregulated metabolism contributes to cancer initiation and progression, but the key drivers of these pathways are just being discovered. Here, we...
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The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS
BackgroundPulmonary and systemic inflammation are central features of chronic obstructive pulmonary disease (COPD). Previous studies have...
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Proline-rich protein 11 overexpression is associated with a more aggressive phenotype and poor overall survival in ovarian cancer patients
BackgroundThe proline-rich protein 11 (PRR11) is a newly identified oncogene associated with a poor prognosis in several human cancers. Nonetheless,...
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Modulation of intestinal metabolites by calorie restriction and its association with gut microbiota in a xenograft model of colorectal cancer
BackgroundColorectal cancer (CRC) is a common malignant tumor, and its occurrence and development are closely related to dysbiosis of gut microbes....
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Curcumin-polyvinyl alcohol nano-composite enhances tolerance of Helianthus annuus L. against salinity stress
BackgroundNanotechnology is a promising technology in many fields including agriculture. So, this investigation aimed to study effect of curcumin...
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A pilot study investigating early postmortem interval of rats based on ambient temperature and postmortem interval-related metabolites in blood
Estimation of the postmortem interval (PMI), especially the early PMI, plays a key role in forensic practice. Although several studies based on...
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Splicing factor proline- and glutamine-rich (SFPQ) protein regulates platinum response in ovarian cancer-modulating SRSF2 activity
In epithelial ovarian cancer (EOC), response to platinum (PT)-based chemotherapy dictates subsequent treatments and predicts patients’ prognosis....
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P4HA2 activates mTOR via hydroxylation and targeting P4HA2-mTOR inhibits lung adenocarcinoma cell growth
Mammalian target of rapamycin (mTOR) kinase functions as a central regulator of cell growth and metabolism, and its complexes mTORC1 and mTORC2...
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Dietary amino acid intake and sleep duration are additively involved in future cognitive decline in Japanese adults aged 60 years or over: a community-based longitudinal study
BackgroundSleep duration and amino acid intake are independently associated with cognitive decline. This study aimed to determine the longitudinal...
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Metabolic signature of the pathogenic 22q11.2 deletion identifies carriers and provides insight into systemic dysregulation
Large deletions at chromosome 22q11.2 are known to cause severe clinical conditions collectively known as 22q11.2 deletion syndrome. Notwithstanding...
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Case report: two novel PPARG pathogenic variants associated with type 3 familial partial lipodystrophy in Brazil
Introduction and aimType 3 Familial Partial Lipodystrophy (FPLD3) is a rare metabolic disease related to pathogenic PPARG gene variants. FPLD3 is...
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Trofinetide: First Approval
Trofinetide (DAYBUE™), an oral, small molecule, synthetic analog of glycine-proline-glutamate [GPE; the N-terminal tripeptide derivative of insulin...
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Urinary metabolomics, dietary salt intake and blood pressure: the African-PREDICT study
In Black populations excessive salt intake may exacerbate the genetic predisposition to hypertension and promote the early onset of cardiovascular...
