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Brusatol sensitizes endometrial hyperplasia and cancer to progestin by suppressing NRF2-TET1-AKR1C1-mediated progestin metabolism
Progestin resistance is the main obstacle for the conservative therapy to maintain fertility in women with endometrial cancer. Brusatol was...
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Fertility-sparing re-treatment for endometrial cancer and atypical endometrial hyperplasia patients with progestin-resistance: a retrospective analysis of 61 cases
ObjectiveThis study aimed to evaluate the oncological and reproductive outcomes of fertility-preserving re-treatment in progestin-resistant...
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The progestin revolution 2: progestins are now a dominant player in the tight interlink between contraceptive protection and bleeding control—plus more
The interlink between bleeding control and contraceptive development has always been an important factor. But after many years of advances in...
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In vitro chemo-preventive efficacy of synthetic progestin Norethindrone in human epithelial ovarian cancer
Progestin-only based oral contraceptives are majorly used as ‘minipill’ to prevent unintended pregnancy and treat conditions like polycystic ovary...
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Meningioma in patients exposed to progestin drugs: results from a real-life screening program
PurposeTo report the results of systematic meningioma screening program implemented by French authorities in patients exposed to progestin therapies...
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Progestin Primed Ovarian Stimulation (PPOS) protocol yields lower euploidy rate in older patients undergoing IVF
BackgroundTo explore if exogenous progestin required for progestin primed ovarian stimulation (PPOS) protocol compromises the euploidy rate of...
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GnRH antagonist protocol versus progestin-primed ovarian stimulation in patients with polycystic ovary syndrome: a systematic review and meta-analysis
PurposeThe aim of this meta-analysis was comparing the efficacy of GnRH antagonist (GnRH-ant) protocol and progestin-primed ovarian stimulation...
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Comparison of fixed and flexible progestin-primed ovarian stimulation protocols to prevent premature luteinization in patients with diminished ovarian reserve
PurposeFlexible progestin-primed ovarian stimulation (PPOS) protocol is demonstrated to be effective in suppressing premature luteinization in few...
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Nomogram to predict FSH starting dose in poor ovarian response women in progestin primed ovarian stimulation protocol
Prediction of individual ovarian response to exogenous gonadotropin is a cornerstone for success and safety in all controlled ovarian stimulation...
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Progestin-related WHO grade II meningiomas behavior—a single-institution comparative case series
WHO grade II progestin-related meningiomas have been reported in recent series but we found no previous study describing their long-term outcome. Our...
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Evaluating the impact of three progestin-based hormonal contraceptive methods on immunologic changes in the female genital tract and systemically (CHIME Study): a prospective cohort study protocol
BackgroundGonadal hormones can modify immune function, which may impact susceptibility to infectious diseases, including Human Immunodeficiency Virus...
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Efficacy and pregnancy outcomes of hysteroscopic surgery combined with progestin as fertility-sparing therapy in patients with early stage endometrial cancer and atypical hyperplasia
PurposeThis study aims to evaluate the efficacy of hysteroscopic curettage combined with progestin therapy in young patients with early-stage...
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Usefulness of random-start progestin-primed ovarian stimulation for fertility preservation
BackgroundProgestin-primed ovarian stimulation (PPOS) has been used in infertility cases in recent years, and several reports have stated that it has...
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Analysis of euploidy rates in preimplantation genetic testing for aneuploidy cycles with progestin-primed versus GnRH agonist/antagonist protocol
BackgroundProgestins can suppress endogenous luteinising hormone (LH) secretion from the pituitary gland and have shown similar efficacy in terms of...
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Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response
After a fortuitous observation of two cases of chemosensitivity recovery in women with congenital central hypoventilation syndrome (CCHS) who took...
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Progestin-primed ovarian stimulation protocol with or without clomiphene citrate for poor ovarian responders: a retrospective cohort study
ObjectiveTo explore the efficacy of progestin-primed ovarian stimulation (PPOS) combined with clomiphene citrate (CC) versus PPOS protocol used alone...
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The construction of machine learning-based predictive models for high-quality embryo formation in poor ovarian response patients with progestin-primed ovarian stimulation
ObjectiveTo explore the optimal models for predicting the formation of high-quality embryos in Poor Ovarian Response (POR) Patients with...
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Evolution of the neurosurgical management of progestin‐associated meningiomas: a 23-year single‐center experience
PurposeThe improving knowledge of interactions between meningiomas and progestin refines the management of this specific condition. We assessed the...
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Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female mice
PurposePAQR7 plays a key role in cell apoptosis as a progesterone membrane receptor. The physiological mechanism of PAQR7 in ovarian function and its...
