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Osteocytes and Primary Cilia
Purpose of ReviewThe purpose of this review is to provide a background on osteocytes and the primary cilium, discussing the role it plays in...
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CRP inhibits the osteoblastic differentiation of OPCs via the up-regulation of primary cilia and repression of the Hedgehog signaling pathway
Inflammation disrupts bone metabolism and leads to bone damage. C-reactive protein (CRP) is a typical inflammation marker. Although CRP measurement...
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TRPP2 is located in the primary cilia of human non-pigmented ciliary epithelial cells
PurposeMechanosensitive channels (MSCs) and primary cilium possess a possible relevance for the sensation of intraocular pressure (IOP). However,...
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Temperature effects on the disappearance and reappearance of corneal-endothelium primary cilia
IntroductionTo elucidate the specific functions of the primary cilia in corneal endothelial cells (CECs) by investigating the histological changes of...
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Primary cilia in hard tissue development and diseases
Bone and teeth are hard tissues. Hard tissue diseases have a serious effect on human survival and quality of life. Primary cilia are protrusions on...
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Flow blockage disrupts cilia-driven fluid transport in the epileptic brain
A carpet of ependymal motile cilia lines the brain ventricular system, forming a network of flow channels and barriers that pattern cerebrospinal...
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Clinical and molecular analysis of cilia-associated gene signature for prognostic prediction in glioma
PurposeGlioma is a highly malignant and unfavorable cancer in the brain. Recent evidence highlights the vital role of cilia-related pathways as novel...
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Kee** pace: the primary cilium as the conducting baton of the islet
Primary cilia are rod-like sensory organelles that protrude from the surface of most mammalian cells, including the cells of the islet, and mounting...
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A change of heart: new roles for cilia in cardiac development and disease
Although cardiac abnormalities have been observed in a growing class of human disorders caused by defective primary cilia, the function of cilia in...
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Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice
Primary ciliary dyskinesia (PCD) is a congenital, motile ciliopathy with pleiotropic symptoms. Although nearly 50 causative genes have been...
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Novel SPEF2 variants cause male infertility and likely primary ciliary dyskinesia
PurposeThis study aimed to identify the genetic causes of male infertility and primary ciliary dyskinesia (PCD)/PCD-like phenotypes in three...
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Characterization of a DRC1 null variant associated with primary ciliary dyskinesia and female infertility
ProposeWe here present a female case with primary ciliary dyskinesia (PCD) and infertility. In this report, we also present the evaluation of the...
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Mechanical stretch promotes apoptosis and impedes ciliogenesis of primary human airway basal stem cells
BackgroundAirway basal stem cells (ABSCs) have self-renewal and differentiation abilities. Although an abnormal mechanical environment related to...
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Primary Ciliary Dyskinesia: Integrating Genetics into Clinical Practice
Purpose of ReviewAdvances in molecular genetics have improved our understanding of primary ciliary dyskinesia. The purpose of this review is to...
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A ZFYVE19 gene mutation associated with neonatal cholestasis and cilia dysfunction: case report with a novel pathogenic variant
BackgroundZFYVE19 (Zinc Finger FYVE-Type Containing 19) mutations have most recently been associated to a novel type of high gamma-glutamyl...
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Clinical Implications of Primary Cilia in Skin Cancer
The primary cilium is a cell surface organelle that is an important component of cellular biology. While it was once believed to be a vestigial...
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Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients
Primary ciliary dyskinesia (PCD) is a highly heterogeneous recessive inherited disorder. FAP54 , the homolog of CFAP54 in Chlamydomonas reinhardtii ,...