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HNF1A gene mutations and premature ovarian failure (POF): evidence from a clinical paradigm combining MODY 3 and POF
Premature ovarian failure (POF) defines the occurrence of ovarian failure prior to the age of 40. It occurs in one out of 100 women but is very rare...
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Efficacy of natural products on premature ovarian failure: a systematic review and meta-analysis of preclinical studies
ObjectiveThis study aims to investigate the effects of natural products on animal models of premature ovarian failure (POF).
MethodsWe conducted...
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Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) alleviate excessive autophagy of ovarian granular cells through VEGFA/PI3K/AKT/mTOR pathway in premature ovarian failure rat model
BackgroundPremature ovarian failure (POF) is one of the leading causes of female infertility and is accompanied by abnormal endocrine, seriously...
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lncRNA-FMR6 directly binds SAV1 to increase apoptosis of granulosa cells in premature ovarian failure
BackgroundA regulatory mechanism of lncRNA binding to protein has been detected in premature ovarian failure (POF). Therefore, this study was...
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Conservative Hypomethylation of Mesenchymal Stem Cells and Their Secretome Restored the Follicular Development in Cisplatin-Induced Premature Ovarian Failure Mice
Premature ovarian failure (POF) is one of the main causes of infertility in women under the age of 40 years. Recently , epigenetic reprogramming,...
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Classical music restored fertility status in rat model of premature ovarian failure
Background:The restorative effect of classical music was assessed on the cyclophosphamide-induced animal model of premature ovarian failure (POF).
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Protective effect of Luffa cylindrica fermentation liquid on cyclophosphamide-induced premature ovarian failure in female mice by attenuating oxidative stress, inflammation and apoptosis
Premature ovarian failure (POF) is a leading cause of women’s infertility without effective treatment. The purpose of this study was to investigate...
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Cytogenetic abnormalities in a sample of females with premature ovarian failure
BackgroundPremature ovarian failure (POF) is a complex heterogeneous disorder characterized by the triad of amenorrhea, hypergonadotropinism, and...
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Mechanisms of action of Zishen Yutai pills in treating premature ovarian failure determined by integrating UHPLC-Q-TOF-MS and network pharmacology analysis
BackgroundZishen Yutai (ZSYT) pill, a patent Chinese medicine, has been widely used in the treatment of infertility, abortion, and adjunctive...
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Ubiquitin-like modifier 1 ligating enzyme 1 relieves cisplatin-induced premature ovarian failure by reducing endoplasmic reticulum stress in granulosa cells
BackgroundUbiquitin-like modifier 1 ligating enzyme 1 (UFL1), the ligase of the UFMylation system, has recently been reported to be involved in...
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LncRNA DLEU1 is overexpressed in premature ovarian failure and sponges miR-146b-5p to increase granulosa cell apoptosis
BackgroundmiR-146b-5p has been reported to participate in premature ovarian failure (POF) in mice. However, its role in POF patients is unclear. We...
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Human Papillomavirus Vaccination and Premature Ovarian Failure: A Disproportionality Analysis Using the Vaccine Adverse Event Reporting System
IntroductionThere have been public health concerns about a potential association between human papillomavirus (HPV) vaccines and premature ovarian...
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MicroRNA-144-3p protects against chemotherapy-induced apoptosis of ovarian granulosa cells and activation of primordial follicles by targeting MAP3K9
Premature ovarian failure (POF) is defined by amenorrhea, ovarian atrophy, hypoestrogenism, elevated gonadotropin level, and infertility under the...
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Prevalence of premature ovarian insufficiency (POI) and its relationship with female reproductive factors in Iranian women: a cross-sectional study from the Persian (Shahedieh) cohort data
BackgroundIn premature ovarian insufficiency, the cessation of menstruation, and cessation of ovarian function occurs before the age of 40, and this...
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Mechanism Exploration of Environmental Pollutants on Premature Ovarian Insufficiency: a Systematic Review and Meta-analysis
As a public health problem, premature ovarian insufficiency leads to infertility or sub-fertility. In addition to premature ovarian insufficiency...
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Effects of single and multiple transplantations of human umbilical cord mesenchymal stem cells on the recovery of ovarian function in the treatment of premature ovarian failure in mice
BackgroundCurrently, there is no effective treatment for premature ovarian failure (POF), and stem cell therapy is considered the most promising...
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The need to identify novel biomarkers for prediction of premature ovarian insufficiency (POI)
BackgroundPremature ovarian failure (POF)/premature ovarian insufficiency (POI) is characterized by disrupting ovarian function under 40 years old. A...
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RegEMR: a natural language processing system to automatically identify premature ovarian decline from Chinese electronic medical records
BackgroundThe ovarian reserve is a reservoir for reproductive potential. In clinical practice, early detection and treatment of premature ovarian...
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Effects of low intensity pulsed ultrasound on expression of B-cell lymphoma-2 and BCL2-Associated X in premature ovarian failure mice induced by 4-vinylcyclohexene diepoxide
BackgroundPremature ovarian failure (POF) is a common disease in the field of Gynecology. Low intensity pulsed ultrasound (LIPUS) can promote tissue...
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What Do Higher Alanine Aminotransferase Levels Mean in Premature Ovarian Insufficiency?
The objective of this study was to investigate the relationship between alanine aminotransferase and related biochemical parameters and potential...
