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Focused ultrasound combined with radiotherapy for malignant brain tumor: a preclinical and clinical study
IntroductionBlood–brain barrier (BBB) remains to be the major obstacle to conquer in treating patients with malignant brain tumors. Radiation therapy...
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Optimizing SUV Analysis: A Multicenter Study on Preclinical FDG-PET/CT Highlights the Impact of Standardization
PurposePreclinical imaging, with translational potential, lacks a standardized method for defining volumes of interest (VOIs), impacting data...
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Chinese Preclinical Alzheimer’s Disease Study (C-PAS): Design and Challenge from PET Acceptance
BackgroundLarge-scale preclinical Alzheimer’s disease study based on β-amyloid positron emission tomography (PET) has not been conducted in China.
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The AlzMatch Pilot Study - Feasibility of Remote Blood Collection of Plasma Biomarkers for Preclinical Alzheimer’s Disease Trials
BackgroundAdvances in plasma biomarkers to detect Alzheimer’s disease (AD) biology allows researchers to improve the efficiency of participant...
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Transmural cross-sectional findings and bowel damage assessment in preclinical Crohn’s disease: a case-control study
PurposeCrohn’s disease (CD) is a progressive disorder leading to cumulative bowel damage. The Lémann index is a validated tool that can help in...
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Exploring Preclinical Medical Students’ Experience Facilitating Group Dialectical Behavior Therapy (DBT) for a Student-Run Mental Health Clinic: A Qualitative Study
ObjectiveThis report explores the experiences of preclinical medical students who led group dialectical behavior therapy (DBT) for a student-run...
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Value of preclinical systematic reviews and meta-analyses in pediatric research
AbstractSimilar to systematic reviews (SRs) in clinical fields, preclinical SRs address a specific research area, furnishing information on current...
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Hinge craniotomy versus standard decompressive hemicraniectomy: an experimental preclinical comparative study
IntroductionDecompressive craniectomy (DC) is the most common surgical procedure to manage increased intracranial pressure (ICP). Hinge craniotomy...
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Image Denoising of Low-Dose PET Mouse Scans with Deep Learning: Validation Study for Preclinical Imaging Applicability
PurposePositron emission tomography (PET) image quality can be improved by higher injected activity and/or longer acquisition time, but both may...
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Introduction to surgery in preclinical years: curriculum development and impact
PurposeExposure to surgery in preclinical years of medical school is traditionally very limited. It is estimated that 59% of students make their...
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The natural history study of preclinical genetic Creutzfeldt-Jakob Disease (CJD): a prospective longitudinal study protocol
BackgroundCreutzfeldt-Jakob Disease (CJD) is the most common prion disease in humans causing a rapidly progressive neurological decline and dementia...
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MIB Guides: Preclinical Radiopharmaceutical Dosimetry
Preclinical dosimetry is essential for guiding the design of animal radiopharmaceutical biodistribution, imaging, and therapy experiments, evaluating...
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Mesenchymal stem cell based therapies for uveitis: a systematic review of preclinical studies
Cell therapy has shown promising results for treating uveitis in preclinical studies. As the field continues to grow towards clinical translation, it...
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Molecular Imaging of Fibroblast Activation in Rabbit Atherosclerotic Plaques: a Preclinical PET/CT Study
AimAtherosclerosis remains the pathological basis of myocardial infarction and ischemic stroke. Early and accurate identification of plauqes is...
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Deciphering the different phases of preclinical inflammatory bowel disease
Inflammatory bowel disease (IBD) is an immune-mediated inflammatory disease (IMID) of the gastrointestinal tract and includes two subtypes: Crohn’s...
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Preclinical magnetic resonance imaging and spectroscopy in the fields of radiological technology, medical physics, and radiology
Magnetic resonance imaging (MRI) is an indispensable diagnostic imaging technique used in the clinical setting. MRI is advantageous over X-ray and...
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[68Ga]Ga-AUNP-12 PET imaging to assess the PD-L1 status in preclinical and first-in-human study
PurposePD-L1 PET imaging, as a non-invasive procedure, can perform a real-time, dynamic and quantitative analysis of PD-L1 expression at tumor sites....
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“Expression of concern”: publication bias for positive preclinical cardioprotection studies
The present analysis reports on the robustness of preclinical cardioprotection studies with infarct size as endpoint which were published in Basic...
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Development of a smartphone screening test for preclinical Alzheimer’s disease and validation across the dementia continuum
BackgroundDementia prevalence is predicted to triple to 152 million globally by 2050. Alzheimer’s disease (AD) constitutes 70% of cases. There is an...
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Lossy Image Compression in a Preclinical Multimodal Imaging Study
The growing use of multimodal high-resolution volumetric data in pre-clinical studies leads to challenges related to the management and handling of...
