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1. A novel preclinical model of the normal human breast

   Improved screening and treatment have decreased breast cancer mortality, although incidence continues to rise. Women at increased risk of breast...

   Anthony J. Wilby, Sara Cabral, ... Hannah Harrison in Journal of Mammary Gland Biology and Neoplasia

   Article Open access 02 May 2024
   

2. Use of patient-derived explants as a preclinical model for precision medicine in colorectal cancer: A sco** review

   Purpose

   Whilst the treatment paradigm for colorectal cancer has evolved significantly over time, there is still a lack of reliable biomarkers of...

   Milton Mui, Molly Clark, ... Joseph C. H. Kong in Langenbeck's Archives of Surgery

   Article Open access 10 October 2023
   

3. Evaluating the Performance of Different Criteria in Diagnosing AD and Preclinical AD with the Bayesian Latent Class Model

   Background

   The diagnostic criteria for Alzheimer’s disease (AD) should be highly sensitive and specific. Clinicians have varying opinions on the...

   X. Wang, G. Niu, ... Qi Gao in The Journal of Prevention of Alzheimer's Disease

   Article 02 April 2024
   

4. Key challenges in exploring the rat as a preclinical neurostimulation model for aortic baroreflex modulation in hypertension

   Electrode-based electrophysiological interfaces with peripheral nerves have come a long way since the 1960s, with several neurostimulation...

   Ibrahim M. Salman in Hypertension Research

   Article 02 November 2023
   

5. Feasibility of the chick chorioallantoic membrane model for preclinical studies on tumor radiofrequency ablation

   Background

   We evaluated the feasibility of a chick chorioallantoic membrane (CAM) tumor model for preclinical research on tumor radiofrequency...

   Joel Wessendorf, Michael Scheschenja, ... Andreas H. Mahnken in European Radiology Experimental

   Article Open access 25 September 2023
   

6. NEMA NU 1-2018 performance characterization and Monte Carlo model validation of the Cubresa Spark SiPM-based preclinical SPECT scanner

   Background

   The Cubresa Spark is a novel benchtop silicon-photomultiplier (SiPM)-based preclinical SPECT system. SiPMs in SPECT significantly improve...

   Matthew E. Strugari, Drew R. DeBay, ... Kimberly D. Brewer in EJNMMI Physics

   Article Open access 01 June 2023
   

7. Lateral fenestration of lumbar intervertebral discs in rabbits: development and characterisation of an in vivo preclinical model with multi-modal endpoint analysis

   Purpose

   To evaluate the biological and biomechanical effects of fenestration/microdiscectomy in an in vivo rabbit model, and in doing so, create a...

   James D. Crowley, Rema A. Oliver, ... William R. Walsh in European Spine Journal

   Article Open access 19 February 2024
   

8. The Balance Between the Therapeutic Efficacy and Safety of [¹⁷⁷Lu]Lu-NeoB in a Preclinical Prostate Cancer Model

   Purpose

   Radiolabeled NeoB is a promising gastrin-releasing peptide receptor (GRPR)–targeting radiopharmaceutical for theranostics of GRPR-expressing...

   Marjolein Verhoeven, Joost Haeck, ... Simone U. Dalm in Molecular Imaging and Biology

   Article Open access 28 August 2023
   

9. Value of preclinical systematic reviews and meta-analyses in pediatric research

   Abstract

   Similar to systematic reviews (SRs) in clinical fields, preclinical SRs address a specific research area, furnishing information on current...

   Olga Romantsik, Matthias Bank, ... Matteo Bruschettini in Pediatric Research

   Article Open access 13 April 2024
   

10. Transjugular Transcatheter Tricuspid Valve Implantation of LuX-Valve Bioprosthesis in a Preclinical Model

    The purpose of this preclinical study in a sheep model was to confirm the feasibility and safety of the LuX-Valve transjugular tricuspid valve (TV)...

    **ao-** Ning, **g-Yi Cao, ... Fang-Lin Lu in Journal of Cardiovascular Translational Research

    Article 23 September 2022
    

11. Preclinical models of bladder cancer: BBN and beyond

    Preclinical modelling is a crucial component of advancing the understanding of cancer biology and therapeutic development. Several models exist for...

    David Matye, Juliann Leak, ... John A. Taylor III in Nature Reviews Urology

    Article 20 May 2024
    

12. MIB Guides: Preclinical Radiopharmaceutical Dosimetry

    Preclinical dosimetry is essential for guiding the design of animal radiopharmaceutical biodistribution, imaging, and therapy experiments, evaluating...

    Lukas M. Carter, Pat B. Zanzonico in Molecular Imaging and Biology

    Article 14 November 2023
    

13. Deciphering the different phases of preclinical inflammatory bowel disease

    Inflammatory bowel disease (IBD) is an immune-mediated inflammatory disease (IMID) of the gastrointestinal tract and includes two subtypes: Crohn’s...

    Jonas J. Rudbaek, Manasi Agrawal, ... Tine Jess in Nature Reviews Gastroenterology & Hepatology

    Article 10 November 2023
    

14. Mesenchymal stem cell based therapies for uveitis: a systematic review of preclinical studies

    Cell therapy has shown promising results for treating uveitis in preclinical studies. As the field continues to grow towards clinical translation, it...

    Pushpinder Kanda, Arnav Gupta, ... Chloe C. Gottlieb in Eye

    Article 10 April 2024
    

15. Recommendations for robust and reproducible preclinical research in personalised medicine

    Background

    Personalised medicine is a medical model that aims to provide tailor-made prevention and treatment strategies for defined groups of...

    Vibeke Fosse, Emanuela Oldoni, ... Teresa Torres in BMC Medicine

    Article Open access 08 January 2023
    

16. Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance

    Cholangiocarcinoma (CCA) is a rare malignancy that develops at any point along the biliary tree. CCA has a poor prognosis, its clinical management...

    Diego F. Calvisi, Luke Boulter, ... Yoshimasa Saito in Nature Reviews Gastroenterology & Hepatology

    Article 08 February 2023
    

17. The use of animal models in preclinical investigations for the development of a surgical mesh for pelvic organ prolapse

    Introduction and hypothesis

    Polypropylene (PP) mesh for the treatment of pelvic organ prolapse (POP) has raised substantial concerns over long-term...

    Amelia Seifalian, Alex Digesu, Vikram Khullar in International Urogynecology Journal

    Article Open access 15 February 2024
    

18. Focused ultrasound combined with radiotherapy for malignant brain tumor: a preclinical and clinical study

    Introduction

    Blood–brain barrier (BBB) remains to be the major obstacle to conquer in treating patients with malignant brain tumors. Radiation therapy...

    Ko-Ting Chen, Chiung-Yin Huang, ... Kuo-Chen Wei in Journal of Neuro-Oncology

    Article 07 December 2023
    

19. Preclinical assessment of a mathematical model for ablation zone prediction in thyroid laser ablation

    To develop and validate a 3D simulation model to calculate laser ablation (LA) zone size and estimate the volume of treated tissue for thyroid...

    Luca Breschi, Ernesto Santos, ... Fourat Ridouani in Lasers in Medical Science

    Article 09 May 2024
    

20. Preclinical magnetic resonance imaging and spectroscopy in the fields of radiological technology, medical physics, and radiology

    Magnetic resonance imaging (MRI) is an indispensable diagnostic imaging technique used in the clinical setting. MRI is advantageous over X-ray and...

    Shigeyoshi Saito, Junpei Ueda in Radiological Physics and Technology

    Article Open access 14 February 2024