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Randomized controlled double-blind trial of methylprednisolone versus placebo in patients with post-COVID-19 syndrome and cognitive deficits: study protocol of the post-corona-virus immune treatment (PoCoVIT) trial
IntroductionPost-COVID-19 Syndrome (PCS) includes neurological manifestations, especially fatigue and cognitive deficits. Immune dysregulation,...
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Factors Affecting Post-trial Sustainment or De-implementation of Study Interventions: A Narrative Review
In contrast to traditional randomized controlled trials, embedded pragmatic clinical trials (ePCTs) are conducted within healthcare settings with...
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Role of preoperative zinc, magnesium and budesonide gargles in Postoperative Sore Throat (POST) - a randomised control trial
BackgroundPost-operative sore throat (POST) has an incidence ranging from 21 to 80%. To prevent the development of POST, several pharmacological...
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Post-trial access to and use of pre-exposure prophylaxis in Durban, South Africa
BackgroundHIV endpoint-driven clinical trials increasingly provide oral pre-exposure prophylaxis (PrEP) as standard of prevention during the trial,...
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Sustained response to atogepant in episodic migraine: post hoc analyses of a 12-week randomized trial and a 52-week long-term safety trial
BackgroundAtogepant is an oral calcitonin gene–related peptide receptor antagonist approved for the preventive treatment of migraine in adults. These...
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Anti-hypertensive medication adherence in the REQUIRE trial: post-hoc exploratory evaluation
Maintaining medication adherence is important in treating hypertension, especially resistant hypertension (RH), and variable medication adherence can...
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Acupuncture plus tongue pressure resistance feedback training for post-stroke deglutition disorders: a randomized controlled trial
ObjectiveTo observe the effect of Tongguan Liqiao (opening orifices) needling plus tongue pressure resistance feedback training in treating...
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Efficacy of massage versus massage with post isometric relaxation in temporomandibular disorders: a randomized controlled trial
BackgroundTemporomandibular joint disorder (TMD) is a common condition affecting the masticatory muscles and joint mobility.
Objectives ...
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Post-abortion needs-based education via the WeChat platform to lessen fear and encourage effective contraception: a post-abortion care service intervention-controlled trial
ObjectiveOur study aims to investigate post-abortion needs-based education via the WeChat platform for women who had intended abortion in the first...
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Febuxostat and renal outcomes: post-hoc analysis of a randomized trial
Effect of urate-lowering on renal outcomes in patients at high-risk for cardiovascular disease with hyperuricemia without gout is not known. We...
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Pre- and post-operative voice therapy for benign vocal fold lesions: protocol for a non-randomised, multicentre feasibility trial with embedded process evaluation
BackgroundManagement of benign vocal fold lesions (BVFLs) is variable with individuals receiving surgery, voice therapy, or a combination of these...
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Blocking CCR5 activity by maraviroc augmentation in post-stroke depression: a proof-of-concept clinical trial
BackgroundPost-stroke depression (PSD) is a significant impediment to successful rehabilitation and recovery after a stroke. Current therapeutic...
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A randomized controlled trial to reduce post-cessation weight gain
Background/ObjectivesWeight gain is a barrier to smoking cessation. Previous interventions targeting weight gain while quitting smoking have largely...
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Post-infusion Costs Associated with Idecabtagene Vicleucel Treatment for Patients with Relapsed/Refractory Multiple Myeloma in the KarMMa Trial
IntroductionPatients with triple-class exposed relapsed/refractory multiple myeloma (RRMM) have poor outcomes with substantial healthcare costs....
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Clinical outcomes of post-placental insertion of Copper T380A and Multiload 375 contraceptive devices during cesarean section: a randomized clinical trial
BackgroundTo compare two types of intrauterine devices, namely Cu T380A IUD and Multiload 375 IUD, inserted immediately post-placental during...
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Switching from eltrombopag to hetrombopag in patients with primary immune thrombocytopenia: a post-hoc analysis of a multicenter, randomized phase III trial
While studies have explored the feasibility of switching between various thrombopoietin receptor agonists in treating immune thrombocytopenia (ITP),...
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Efficacy of supervised
i mmersive virtual reality-based training for the treatment of chronic fatigue in post-COVID syndrome: study protocol for a double-blind randomized controlled trial (IFATICO Trial)BackgroundThe treatment of persistent fatigue after COVID-19 infection is complex. On the one hand, it involves maintaining a sufficient level of...
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Awareness with paralysis and symptoms of post-traumatic stress disorder among mechanically ventilated emergency department survivors (ED-AWARENESS-2 Trial): study protocol for a pragmatic, multicenter, stepped wedge cluster randomized trial
BackgroundAwareness with paralysis (AWP) is memory recall during neuromuscular blockade (NMB) and can cause significant psychological harm. Decades...
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Pilot randomized controlled trial of restricted versus liberal crystalloid fluid management in pediatric post-operative and trauma patients
BackgroundIntravenous (IV) fluid therapy is essential in the treatment of critically ill pediatric surgery and trauma patients. Recent studies have...
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Oral midodrine for prophylaxis against post-spinal anesthesia hypotension during hip arthroplasty in elderly population: a randomized controlled trial
BackgroundWe aimed to evaluate the efficacy of midodrine as a prophylaxis against post-spinal hypotension in elderly patients undergoing hip...
