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Resveratrol reduces platelet storage lesion by preventing free mitochondrial DNA (mtDNA) accumulation in platelet concentrates during storage
Platelet activation and mitochondrial damage are among the crucial events leading to the quality reduction of platelet concentrates (PCs) during...
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A comparative study of platelet storage lesion in platelet-rich plasma under cryopreservation
Platelet-rich plasma (PRP) has significant potential for various applications and holds clinical value in regenerative medicine. Cryopreservation is...
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l-carnitine modulates free mitochondrial DNA DAMPs and platelet storage lesions during storage of platelet concentrates
Platelet storage lesions may occur in Platelet concentrates (PCs) storage time, reducing PCs' quality. Mitochondrial damage causes mitochondrial DNA...
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Platelet storage: Progress so far
There is a crucial need for platelet transfusion during an emergency—surgery and treatment of platelet disorders. The unavailability of donors has...
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Cost Effectiveness of Different Platelet Preparation, Storage, Selection and Dosing Methods in Platelet Transfusion: A Systematic Review
Background and ObjectiveEvidence-based guidelines on platelet transfusion therapy assist clinicians to optimize patient care, but currently do not...
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High Autophagy Patterns in Swelling Platelets During Apheresis Platelet Storage
Platelets undergo remarkable morphological changes during storage. Platelets change into different sizes and densities and differ in their...
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Comparing transfusion reactions between pre-storage and post-storage leukoreduced apheresis platelets: an analysis using propensity score matching
Transfusion reactions induced by platelet transfusions may be reduced and alleviated by leukocyte reduction of platelets. Although leukoreduction of...
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Agitation-dependent biomechanical forces modulate GPVI receptor expression and platelet adhesion capacity during storage
BackgroundContinuous agitation during storage slows down the platelet storage lesions. However, in special circumstances, manual-mixing can be...
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Role of MicroRNA-326 and its Target Genes Bcl-xL and Bak as Potential Markers in Platelet Storage Lesion in Blood Banks
Platelet transfusion is crucial in the management of various conditions such as quantitative and qualitative platelet disorders. A serious problem...
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Prophylactic platelet transfusion response in critically ill patients: a prospective multicentre observational study
BackgroundResponse to prophylactic platelet transfusion is suspected to be inconsistent in critically ill patients questioning how to optimize...
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Platelet Transfusion for Trauma Resuscitation
Purpose of ReviewTo review the role of platelet transfusion in resuscitation for trauma, including normal platelet function and alterations in...
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Perioperative Platelet Transfusion: Not All Platelet Products Are Created Equal
Purpose of ReviewThis review highlights current advances in platelet components for transfusion in the perioperative setting while explaining point...
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Analysis of changes in the expression pattern of miR-326 and miR-145 during storage of platelet concentrate in blood bank condition and its relationship with some markers of platelet quality
Platelet concentrates (PC) are affected by biochemical, morphological and functional changes during storage that are named platelet storage lesion...
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The Usability of Platelet Mass Index Thresholds to Assess the Repeated Platelet Transfusion Requirements in Neonates
To evaluate the usability of platelet mass index (PMI) thresholds to assess the repeated platelet transfusion requirements in neonates who have...
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Changes in inflammatory proteins following platelet transfusion in a neonatal population
BackgroundStudies have demonstrated increased morbidity and mortality with platelet transfusions in the neonatal period. Platelets are as important...
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Platelet aggregates detected using quantitative phase imaging associate with COVID-19 severity
BackgroundThe clinical spectrum of acute SARS-CoV-2 infection ranges from an asymptomatic to life-threatening disease. Considering the broad spectrum...
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Dose-dependent effect of canine lyophilized platelet on an in vitro hemodilution model
The transfusion of stored platelets has emerged as an efficient method for treating dogs with thrombocytopenia. However, the availability of fresh...
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Delayed cold-stored vs. room temperature stored platelet transfusions in bleeding adult cardiac surgery patients—a randomized multicentre pilot study (PLTS-1)
BackgroundPlatelets stored at 1–6 °C are hypothesized to be more hemostatically active than standard room temperature platelets (RTP) stored at...
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Efficacy of intra-articular injection of allogeneic platelet-rich plasma for knee osteoarthritis combined with hematologic blood dyscrasias with platelet dysfunction: protocol of a randomized, double-blind, placebo-controlled trial
BackgroundAutologous platelet-rich plasma (PRP) has been shown to alleviate the symptoms of patients suffering from knee osteoarthritis (KOA), but...
