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Impact of rise and fall phases of shear on platelet activation and aggregation using microfluidics
Blood flow disorders are often the result of the non-physiological narrowing of blood arteries caused by atherosclerosis and thrombus. The blood then...
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Differential platelet activation through an interaction with spike proteins of different SARS-CoV-2 variants
COVID-19 disease is associated with an increased risk of thrombotic complications, which contribute to high short-term mortality. Patients with...
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Differentially expressed platelet activation-related genes in dogs with stage B2 myxomatous mitral valve disease
BackgroundPeripheral blood carries a reservoir of mRNAs that regulate cardiac structure and function potential. Although it is well recognized that...
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Lipoxin A4 analogue, BML-111, reduces platelet activation and protects from thrombosis
Formyl peptide receptors (FPRs) are members of seven transmembrane G protein-coupled receptors superfamily that exhibit different responses based on...
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Sodium bicarbonate as a local adjunctive agent for limiting platelet activation, aggregation, and adhesion within cardiovascular therapeutic devices
Cardiovascular therapeutic devices (CTDs) remain limited by thrombotic adverse events. Current antithrombotic agents limit thrombosis partially,...
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Markers of platelet activation foR identification of late onset sEpsis in infaNTs: PARENT study protocol
BackgroundNewborns are at high risk of sepsis. At present there is no definitive “rule in” blood test for sepsis at the point of clinical concern. A...
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Thyroid hormones and platelet activation in COVID-19 patients
PurposeTo retrospectively describe the association between thyroid hormones (TH) and platelet activation, as represented by mean platelet volume...
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Variant-derived SARS-CoV-2 spike protein does not directly cause platelet activation or hypercoagulability
Thrombosis has been associated with severity and mortality in COVID-19. SARS-CoV-2 infects the host via its spike protein. However, direct effects of...
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Resveratrol reduces platelet storage lesion by preventing free mitochondrial DNA (mtDNA) accumulation in platelet concentrates during storage
Platelet activation and mitochondrial damage are among the crucial events leading to the quality reduction of platelet concentrates (PCs) during...
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Platelet-rich plasma alleviates neuropathic pain in osteoarthritis by downregulating microglial activation
BackgroundThe development of neuropathic pain (NP) is one of the reasons why the pain is difficult to treat, and microglial activation plays an...
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Impact of obstructive sleep apnea on platelet activation and development of silent brain infarctions
BackgroundObstructive sleep apnea (OSA) is a unique potent predictor for stroke compared to other predictors. By aiding in the adherence of...
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A comparative study of platelet storage lesion in platelet-rich plasma under cryopreservation
Platelet-rich plasma (PRP) has significant potential for various applications and holds clinical value in regenerative medicine. Cryopreservation is...
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Platelet and large platelet ratios are useful in predicting severity of COVID-19
The role of platelets in coronavirus disease (COVID-19) severity requires further exploration. To determine whether the platelet index is useful in...
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Platelet Activation Markers in Children with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease
The study aimed to evaluate mean platelet volume (MPV), platelet distribution width (PDW), and platecrit in children with pulmonary arterial...
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Ligand-independent activation of platelet-derived growth factor receptor β promotes vitreous-induced contraction of retinal pigment epithelial cells
BackgroundEpiretinal membranes in patients with proliferative vitreoretinopathy (PVR) consist of extracellular matrix and a number of cell types...
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Thrombosis in COVID-19 infection: Role of platelet activation-mediated immunity
BackgroundThrombosis plays an important role in the Coronavrus Disease 2019 (COVID-19) infection-related complications such as acute respiratory...
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Nourishing the clot: a comprehensive review of dietary habits and their implications for platelet function
This review elucidates the intricate relationship between dietary habits and platelet function, emphasizing the influential role of berries. Both...
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Association of PCSK9 with inflammation and platelet activation markers and recurrent cardiovascular risks in STEMI patients undergoing primary PCI with or without diabetes
BackgroundProprotein convertase subtilisin/kexin type 9 (PCSK9) has been shown to be predictive of cardiovascular outcomes in stable coronary artery...
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Platelet indices and blood pressure: a multivariable mendelian randomization study
BackgroundPlatelet indices are blood-based parameters reflecting the activation of platelets. Previous studies have identified an association between...
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Evaluating mean platelet volume and platelet distribution width as predictors of early-onset pre-eclampsia: a prospective cohort study
BackgroundPlatelets are pivotal players in the pathophysiology of pre-eclampsia, with observed lower counts in affected individuals compared to...
