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Plasma proteins and inflammatory dermatoses: proteome-wide Mendelian randomization and colocalization analyses
Current genome-wide association studies (GWAS) of plasma proteomes provide additional possibilities for finding new drug targets for inflammatory...
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High dietary inflammatory index associates with inflammatory proteins in plasma
Background and aimUnhealthy dietary habits and highly caloric foods induce metabolic alterations and promote the development of the inflammatory...
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Plasma proteins related to inflammatory diet predict future cognitive impairment
Dysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by...
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Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic response in acute promyelocytic leukemia
The treatment of PML/RARA+ acute promyelocytic leukemia (APL) with all-trans-retinoic acid and arsenic trioxide (ATRA/ATO) has been recognized as a...
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Screening for Circulating Inflammatory Proteins Does Not Reveal Plasma Biomarkers of Constant Tinnitus
Background and ObjectiveTinnitus would benefit from an objective biomarker. The goal of this study is to identify plasma biomarkers of constant and...
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Determination of 3- and 4-chloromethcathinone interactions with plasma proteins: study involving analytical and theoretical methods
PurposeThe purpose of this paper was to determine 3- and 4-chloromethcathinone (3- and 4-CMC) binding degree and possible binding interaction modes...
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Starch intake, amylase gene copy number variation, plasma proteins, and risk of cardiovascular disease and mortality
BackgroundSalivary amylase, encoded by the AMY1 gene, initiate the digestion of starch. Whether starch intake or AMY1 copy number is related to...
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Milk intake, lactase persistence genotype, plasma proteins and risks of cardiovascular events in the Swedish general population
To investigate the associations of milk intake (non-fermented and fermented milk), lactase persistence ( LCT -13910 C/T) genotype (a proxy for...
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Identifying novel proteins underlying schizophrenia via integrating pQTLs of the plasma, CSF, and brain with GWAS summary data
BackgroundSchizophrenia (SCZ) is a chronic and severe mental illness with no cure so far. Mendelian randomization (MR) is a genetic method widely...
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Comparative proteomic exploration of plasma proteins in different levels of vitamin D with type 2 diabetes mellitus using iTRAQ-coupled LC-MS/MS
ObjectivesDue to the variety of modern diet and lifestyle changes, China has become the world’s largest number of people with T2DM. How to prevent...
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Integrated glycomics and genetics analyses reveal a potential role for N-glycosylation of plasma proteins and IgGs, as well as the complement system, in the development of type 1 diabetes
Aims/hypothesisWe previously demonstrated that N-glycosylation of plasma proteins and IgGs is different in children with recent-onset type 1 diabetes...
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Network analysis of plasma proteomes in affective disorders
The conventional differentiation of affective disorders into major depressive disorder (MDD) and bipolar disorder (BD) has insufficient biological...
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Proteomic insights into mental health status: plasma markers in young adults
Global emphasis on enhancing prevention and treatment strategies necessitates an increased understanding of the biological mechanisms of...
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Children at onset of type 1 diabetes show altered N-glycosylation of plasma proteins and IgG
Aims/hypothesisIndividual variation in plasma N -glycosylation has mainly been studied in the context of diabetes complications, and its role in type...
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Plasma and cerebrospinal fluid inflammatory markers and human aggression
A growing body of work suggests that individuals with aggressive behavior and/or aggressive tendencies have evidence of chronic, low level,...
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Non-linear plasma protein binding of cannabidiol
BackgroundCannabidiol is highly bound to plasma proteins. Changes in its protein binding can lead to altered unbound plasma concentrations and result...
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Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder
To characterize neuronal mitochondrial abnormalities in major depressive disorder (MDD), functional mitochondrial proteins (MPs) extracted from...
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Longitudinal plasma proteomic analysis identifies biomarkers and combinational targets for anti-PD1-resistant cancer patients
The response rate of anti-PD1 therapy is limited, and the influence of anti-PD1 therapy on cancer patients is unclear. To address these challenges,...
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Plasma-Derived Medicinal Products in Nigeria
Plasma-derived medicinal products (PDMPs) are pharmaceutical products that are derived from human plasma, the liquid part of blood that contains...