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Characterization of Plasma SDS-Protein Aggregation Profile of Patients with Heart Failure with Preserved Ejection Fraction
This study characterizes the plasma levels and composition of SDS-resistant aggregates (SRAs) in patients with heart failure with preserved ejection...
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Effects of switching from sacubitril/valsartan to valsartan alone on plasma levels of natriuretic peptides and myocardial remodeling in heart failure with reduced ejection fraction
BackgroundWe examined the effect of switching from angiotensin receptor-neprilysin inhibitor (ARNI) to angiotensin-receptor blocker (ARB) on plasma...
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Non-linear plasma protein binding of cannabidiol
BackgroundCannabidiol is highly bound to plasma proteins. Changes in its protein binding can lead to altered unbound plasma concentrations and result...
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Efficacy and Safety of Transplantation of Autologous Fat, Platelet-Rich Plasma (PRP) and Stromal Vascular Fraction (SVF) in the Treatment of Acne Scar: Systematic Review and Meta-analysis
BackgroundThe efficacy and safety evaluation of the transplantation of autologous fat, platelet-rich plasma (PRP) and stromal vascular fraction (SVF)...
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Flaxseed oil fraction reverses cardiac remodeling at a molecular level: improves cardiac function, decreases apoptosis, and suppresses miRNA-29b and miRNA 1 gene expression
Flaxseed is an ancient commercial oil that historically has been used as a functional food to lower cholesterol levels. However, despite its...
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Epicardial Adipose Tissue Thickness and Preserved Ejection Fraction Heart Failure
Purpose of the ReviewPreserved ejection fraction heart failure and obesity frequently coexist. Whether obesity plays a consistent role in the...
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The non-steroidal mineralocorticoid receptor antagonist finerenone and heart failure with preserved ejection fraction
Finerenone is a novel non-steroidal mineralocorticoid receptor (MR) antagonist (MRA) with high binding affinity, high MR selectivity and a short...
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New improved radiometabolite analysis method for [18F]FTHA from human plasma: a test-retest study with postprandial and fasting state
BackgroundFatty acid uptake can be measured using PET and 14-( R,S )‐[ 18 F]fluoro‐6‐thia‐heptadecanoic acid ([ 18 F]FTHA). However, the relatively rapid...
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Association between fetal fraction of cell-free DNA and adverse pregnancy outcomes
PurposeTo determine the association between fetal fraction (FF) levels in cell-free fetal DNA (cffDNA) testing and adverse pregnancy outcomes.
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Could Fetal Fraction Index Affect Maternal Serum Biomarkers or Uterine Artery Pulsatility Index in the First Trimester?
In the current study, we aimed to investigate the correlation between fetal fraction index extracted during first or early second trimester with the...
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Long-term outcomes prediction in diabetic heart failure with preserved ejection fraction by cardiac MRI
ObjectivesWe aimed to explore imaging features including tissue characterization and myocardial deformation in diabetic heart failure with preserved...
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Prognostic relevance of elevated plasma osmolality on admission in acute decompensated heart failure with preserved ejection fraction: insights from PURSUIT-HFpEF registry
BackgroundComplicated pathophysiology makes it difficult to identify the prognosis of heart failure with preserved ejection fraction (HFpEF). While...
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High Variability in Isavuconazole Unbound Fraction in Clinical Practice: A Call to Reconsider Pharmacokinetic/Pharmacodynamic Targets and Breakpoints
Isavuconazole exposure–response relationships have been studied with a focus on total rather than unbound exposure, assuming a constant unbound...
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Cost–Utility Analysis of Vericiguat in Heart Failure with Reduced Ejection Fraction After Worsening Heart Failure Events in China
ObjectiveVericiguat is a new medication to demonstrate clinical efficacy in heart failure with reduced ejection fraction (HFrEF) after worsening...
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Plasma microRNA-143 and microRNA-145 levels are elevated in patients with left ventricular dysfunction
MicroRNA(miR)-143 and miR-145 are mainly expressed in vascular smooth muscle cells. However, the relationship between plasma miR-143 or miR-145...
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Efficacy and safety of autologous adipose-derived stromal vascular fraction enriched with platelet-rich plasma in flap repair of transsphincteric cryptoglandular fistulas
BackgroundTransanal advancement flap repair of transsphincteric fistulas is a sphincter-preserving procedure, which frequently fails, probably due to...
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Plasma versican and plasma exosomal versican as potential diagnostic markers for non-small cell lung cancer
Background and aimsThis study aimed to investigate the expression of plasma versican and plasma exosomal versican in non-small cell lung cancer...
