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Plasma metabolomic profile in orthostatic intolerance children with high levels of plasma homocysteine
BackgroundOrthostatic intolerance, which includes vasovagal syncope and postural orthostatic tachycardia syndrome, is common in children and...
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Pharmacokinetic Study of Conjugated Equine Estrogens in Healthy Chinese Postmenopausal Women Using a Parallel Two-Column LC–MS/MS Method
Background and ObjectivePostmenopausal women often require estrogen supplementation to improve menopausal and postmenopausal vasomotor symptoms and...
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Bioanalytical method development, validation and quantification of flutamide in spiked rat plasma by using high-performance liquid chromatography
BackgroundA quick, low cost and precise method was developed and validated for flutamide in the rat plasma using a high-performance liquid...
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Non-linear plasma protein binding of cannabidiol
BackgroundCannabidiol is highly bound to plasma proteins. Changes in its protein binding can lead to altered unbound plasma concentrations and result...
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Associations of maternal plasma and umbilical cord plasma metabolomics profiles with birth anthropometric measures
BackgroundThe metabolomics profiles of maternal plasma during pregnancy and cord plasma at birth might influence fetal growth and birth...
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Bioanalytical method development and validation for quantification of amivantamab in rat plasma by LC-MS/MS
BackgroundAmivantamab is a monoclonal bispecific anti-EGFR-MET antibody used to treat non-small cell lung cancer. There were no published methods...
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Network analysis of plasma proteomes in affective disorders
The conventional differentiation of affective disorders into major depressive disorder (MDD) and bipolar disorder (BD) has insufficient biological...
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Alteration of Plasma Indoles in Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in reproductive-aged women. The occurrence of PCOS was reported to be...
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A simple high-performance liquid chromatographic assay for concurrent quantification of lumefantrine and efavirenz in human plasma from malaria–HIV co-infected individuals
BackgroundAs per current treatment guidelines, artemether-lumefantrine and efavirenz-based antiretroviral therapy are recommended drugs for...
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Proteomic insights into mental health status: plasma markers in young adults
Global emphasis on enhancing prevention and treatment strategies necessitates an increased understanding of the biological mechanisms of...
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Bioanalytical method development and validation for the simultaneous estimation of Olanzapine and Samidorphan in rabbit plasma by using HPLC–MS/MS and application to pharmacokinetic study
BackgroundSamidorphan is an opioid antagonist while Olanzapine is an effective medication for schizophrenia and bipolar disorder. A unique and...
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A simple method for the determination of acyclovir concentrations in human plasma using high-performance liquid chromatography
BackgroundAcyclovir is an anti-viral medication given to treat herpes simplex and herpes zoster infection. In some severe conditions such as herpes...
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Characterization of extrachromosomal circular DNAs in plasma of patients with clear cell renal cell carcinoma
Background and PurposeExtrachromosomal circular DNAs (eccDNAs) have been recognized for their significant involvement in numerous biological...
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Determination of lamotrigine in human plasma by HPLC-PDA. Application to forensic samples
PurposeTherapeutic drug monitoring of plasma lamotrigine (LTG) has customarily been carried out in order to prevent some its adverse effects. For...
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Adiposity associates with lower plasma resolvin E1 (Rve1): a population study
BackgroundInadequate inflammation resolution may contribute to persistent low-grade inflammation that accompanies many chronic conditions. Resolution...
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Plasma microRNA-143 and microRNA-145 levels are elevated in patients with left ventricular dysfunction
MicroRNA(miR)-143 and miR-145 are mainly expressed in vascular smooth muscle cells. However, the relationship between plasma miR-143 or miR-145...
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The Role of Platelet Rich Plasma in Vertebrogenic and Discogenic Pain: A Systematic Review and Meta-Analysis
Purpose of ReviewThe present investigation evaluates clinical uses and roles of platelet rich plasma in the management of vetrebrogenic and...
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Possible-sarcopenic screening with disturbed plasma amino acid profile in the elderly
BackgroundThe mass and strength of skeletal muscle decline with age, leading to its progressive dysfunction. High-throughput metabolite profiling...
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In-vitro Dilution of Human Plasma to Reduce ABO Antibody Titer Levels While Preserving Coagulation Factors
The objective of this study was to prepare universal plasma by mixing Group A and Group B plasma with normal saline in varying proportions. This...
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Plasma protein N-glycome composition associates with postprandial lipaemic response
BackgroundA dysregulated postprandial metabolic response is a risk factor for chronic diseases, including type 2 diabetes mellitus (T2DM). The plasma...
