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Validation of plasma protein glycation and oxidation biomarkers for the diagnosis of autism
Autism Spectrum Disorder (ASD) is a common neurodevelopmental disorder in children. It is currently diagnosed by behaviour-based assessments made by...
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Perioperative redox changes in patients undergoing hepato-pancreatico-biliary cancer surgery
BackgroundTissue injury induces inflammation and the surgical stress response, which are thought to be central to the orchestration of recovery or...
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Elevated plasma interleukin-8 as a risk factor for mortality in children presenting with cerebral malaria
BackgroundCerebral malaria (CM) is a neuropathology which remains one of the deadliest forms of malaria among African children. The kinetics of the...
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Effect of antioxidant-rich kindergarten meals on oxidative stress biomarkers in healthy 5–6-year-old children: a randomized controlled trial
As children spend up to 9 h a day in kindergarten, the main purpose of our study was to evaluate the effect of antioxidant-rich kindergarten meals on...
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Mitochondria-targeted antioxidant supplementation improves 8 km time trial performance in middle-aged trained male cyclists
BackgroundExercise increases skeletal muscle reactive oxygen species (ROS) production, which may contribute to the onset of muscular fatigue and...
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Cocoa Consumption Decreases Oxidative Stress, Proinflammatory Mediators and Lipid Peroxidation in Healthy Subjects: A Randomized Placebo-Controlled Dose-Response Clinical Trial
IntroductionCocoa flavonoids have been described to reduce the cardiovascular risk. Nevertheless, the involved mechanisms should be clarified and the...
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Lipid-Lowering Medications are Associated with Reduced Sarcopenia-Related Quality of Life in Older Adults with Hyperlipidemia
PurposeStatins medications negatively affect age-associated loss of muscle mass and strength, termed sarcopenia, and neuromuscular junction (NMJ)...
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Plasma glutathione as a risk marker for the severity and functional outcome of acute atherothrombotic and cardioembolic stroke
ObjectiveGlutathione (GSH) is a major intracellular thiol-containing antioxidant. We tried to determine whether blood plasma GSH level is a marker...
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A leaky gut contributes to reduced sarcopenia-related quality of life (SarQoL) in geriatric older adults
PurposeThe sarcopenia quality-of-life (SarQoL) questionnaire is designed to evaluate the quality of life of sarcopenic patients. A pathological...
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Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial
BackgroundFew randomized clinical trials have explored the health effects of bilberries in humans. The aim was to test the effect of bilberry and red...
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Early versus late parenteral nutrition in term and late preterm infants: study protocol for a randomised controlled trial
BackgroundDespite the wide use of parenteral nutrition (PN) in neonatal intensive care units (NICU), there is limited evidence regarding the optimal...
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Supplementation of vitamin E as an addition to a commercial renal diet does not prolong survival of cats with chronic kidney disease
BackgroundThe aim of this double-blind, placebo-controlled study was to investigate the effect of vitamin E supplementation as an addition to a...
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Relationship Between Semen IL-6, IL-33 and Malondialdehyde Generation in Human Seminal Plasma and Spermatozoa
Cytokines are physiological seminal components and their abnormal levels, reported in different pathological conditions, negatively influence the...
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Expression levels of plasma exosomal miR-124, miR-125b, miR-133b, miR-130a and miR-125b-1-3p in severe asthma patients and normal individuals with emphasis on inflammatory factors
BackgroundIdentification of molecular markers, such as miRNAs is promising for the diagnosis of asthma and its clinical phenotypes. The aim of this...
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Association between plasmatic oxidative stress and thrombosis in primary antiphospholipid syndrome
Antiphospholipid antibodies induce a pro-inflammatory and hypercoagulable state that lead to increased risk of thrombosis. Whether oxidative damage...
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Serum antioxidant vitamin concentrations and oxidative stress markers associated with symptoms and severity of premenstrual syndrome: a prospective cohort study
BackgroundIt has been suggested that premenstrual syndrome (PMS) may derive from either elevated oxidative stress or reduced antioxidant vitamin...
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Traditional and novel diagnostic biomarkers for acute myocardial infarction
BackgroundAcute myocardial infarction (AMI) is a leading cause of death worldwide. The first hours of acute myocardial infarction are correlated with...
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The effects of exercise and diet on oxidative stress and telomere length in breast cancer survivors
PurposeCancer and its treatments accelerate biological aging. This analysis tested the hypothesis that exercise and diet reduce oxidative stress and...
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The Critical Role of Biomarkers for Drug Development Targeting the Biology of Aging
Alzheimer’s disease is a devastating neurodegenerative disorder that poses a significant societal burden. Approval of anti-amyloid antibody therapies...