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Pituitary crosstalk with bone, adipose tissue and brain
Traditional textbook physiology has ascribed unitary functions to hormones from the anterior and posterior pituitary gland, mainly in the regulation...
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Atypical pituitary hormone-target tissue axis
A long-held belief is that pituitary hormones bind to their cognate receptors in classical target glands to actuate their manifold functions....
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Diagnosing and treating anterior pituitary hormone deficiency in pediatric patients
Hypopituitarism, or the failure to secrete hormones produced by the anterior pituitary (adenohypophysis) and/or to release hormones from the...
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Pituitary stem cells: past, present and future perspectives
Pituitary cells that express the transcription factor SOX2 are stem cells because they can self-renew and differentiate into multiple pituitary...
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Endoscopic trans-sphenoidal pituitary surgery does not impact postoperative nasal quality of life
PurposeThe aim of this prospective longitudinal study was to assess both subjective quality of life using questionnaires and objective examination of...
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Subclinical central hypothyroidism in patients with hypothalamic-pituitary disease: does it exist?
Central hypothyroidism (CH) is characterized by decreased thyroid hormone production due to insufficient stimulation of an otherwise normal thyroid...
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Physiological linkage of thyroid and pituitary sensitivities
ObjectivesThe sensitivities of the pituitary to thyroxine feedback, and the thyroid to thyrotropin stimulation determine the free thyroxine...
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A Systematic Review of Stress Physiology in Gambling Disorder and Problem Gambling
Purpose of ReviewStress may contribute to the onset and symptoms of maladaptive gambling behaviour. However, minimal work investigates stress...
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The hallmarks of cancer… in pituitary tumors?
Over 20 years ago, Hanahan and Weinberg published a seminal review that addressed the biological processes that underly malignant transformation....
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Aging and androgens: Physiology and clinical implications
In men > ~35 years, aging is associated with perturbations in the hypothalamus-pituitary–testicular axis and declining serum testosterone...
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Excess mortality in patients with non-functioning pituitary adenoma: a systematic review and meta-analysis
BackgroundPatients with non-functioning pituitary adenoma (NFPA) often present with a variety of clinical manifestations and comorbidities, mainly...
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Extra-pseudocapsular Transnasal Transsphenoidal Resection of Pituitary Macroadenoma: Technique Note and Evaluation of Endocrine Function
ObjectiveIn this study, we investigated the surgical technique and endocrine assessment of pituitary function of patients with macroadenoma treated...
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A randomized prospective comparative study on sinonasal morbidity and quality of life of transsphenoidal endoscopic surgery for pituitary adenomas: endonasal versus trans-septal approach
PurposeEndoscopic endonasal transsphenoidal approach (Endonasal approach) is commonly used to treat pituitary adenomas. The extent of dissection...
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Sleep quality in patients with non-functioning pituitary adenoma: impact of replacement therapies with an emphasis on the time of hydrocortisone
PurposeSleep disturbances are widespread and associated with pituitary diseases, even those under long-term therapeutic management. The aim of this...
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Endocrine and cellular physiology and pathology of the insulin-like growth factor acid-labile subunit
The acid-labile subunit (ALS) of the insulin-like growth factor (IGF) binding protein (IGFBP) complex, encoded in humans by IGFALS , has a vital role...
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Overview of the 2022 WHO Classification of Pituitary Tumors
This review summarizes the changes in the 5th Edition of the WHO Classification of Endocrine and Neuroendocrine Tumors that relate to the pituitary...
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Adrenal insufficiency in pregnancy: Physiology, diagnosis, management and areas for future research
Adrenal insufficiency requires prompt diagnosis in pregnancy, as untreated, it can lead to serious consequences such as adrenal crisis, intrauterine...
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Vascular anomalies in patients with growth hormone-secreting pituitary adenomas: illustrative case report and systematic review of the literature
PurposeEndonasal resection is the first-line treatment for patients harboring growth hormone (GH)-secreting pituitary adenomas. The complexity of the...
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Evaluation of the expression of necroptosis pathway mediators and its association with tumor characteristics in functional and non-functional pituitary adenomas
BackgroundPituitary adenomas impose a burden of morbidity on patients and characterizing the molecular mechanisms underlying its pathogenesis...
