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Morphofunctional analysis of fibroblast-like synoviocytes in human rheumatoid arthritis and mouse collagen-induced arthritis
BackgroundFibroblast-like synoviocytes (FLS) play a prominent role in rheumatoid synovitis and degradation of the extracellular matrix through the...
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Colostrogenesis: Role and Mechanism of the Bovine Fc Receptor of the Neonate (FcRn)
Colostrogenesis is a separate and unique phase of mammary epithelial cell activity occurring in the weeks before parturition and rather abruptly...
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Human umbilical cord mesenchymal stem cell-derived exosomes promote microcirculation in aged diabetic mice by TGF-β1 signaling pathway
BackgroundMicrovascular dysfunction is one of the most common pathological characteristics in Type 2 diabetes. Human mesenchymal stem cell-derived...
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Transport and Possible Outcome of Lipofuscin in Mouse Myocardium
AbstractThis study was performed to clarify the transfer and final end of lipofuscin substances that have been formed in cardiomyocytes. The hearts...
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Pathological features of biopsied myocardium in patients clinically diagnosed with peripartum cardiomyopathy
The etiology of peripartum cardiomyopathy (PPCM) is unknown. Therefore, we evaluated the etiology of patients clinically diagnosed with PPCM using...
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SARS-CoV-2 identified by transmission electron microscopy in lymphoproliferative and ischaemic intestinal lesions of COVID-19 patients with acute abdominal pain: two case reports
BackgroundSARS-CoV-2 may produce intestinal symptoms that are generally mild, with a small percentage of patients develo** more severe symptoms....
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Skeletal and extraskeletal disorders of biomineralization
The physiological process of biomineralization is complex and deviation from it leads to a variety of diseases. Progress in the past 10 years has...
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Assessment of single and combined administration of ubiquinone and lactoferrin on histopathology, ultrastructure, oxidative stress, and WNT4 expression gene induced by thioacetamide on hepatorenal system of adult male rats
BackgroundHepatorenal syndrome is a life-threatening medical complication of liver cirrhosis. Hepatic cirrhosis is commonly accompanied by rapid...
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Neurological manifestations of SARS-CoV-2: complexity, mechanism and associated disorders
BackgroundCoronaviruses such as Severe Acute Respiratory Syndrome coronavirus (SARS), Middle Eastern Respiratory Syndrome (MERS) and Severe Acute...
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New Drug Delivery Systems Developed for Brain Targeting
The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (B CSF ) are two of the most complex and sophisticated concierges that defend...
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Molecular and genetic mechanisms in brain arteriovenous malformations: new insights and future perspectives
Brain arteriovenous malformations (bAVMs) are rare vascular lesions made of shunts between cerebral arteries and veins without the interposition of a...
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The Role of Arachnoid Granulations and the Glymphatic System in the Pathophysiology of Idiopathic Intracranial Hypertension
Purpose of ReviewIdiopathic intracranial hypertension (IIH) is a disorder characterized by long-standing elevated intracranial pressure (ICP). As the...
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Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm
Primary non-neuroendocrine tumours of the pituitary gland and sella are rare lesions often challenging to diagnose. We describe two cases of...
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In situ vaccination with laser interstitial thermal therapy augments immunotherapy in malignant gliomas
IntroductionLaser interstitial thermal therapy (LITT) remains a promising advance in the treatment of primary central nervous system malignancies. As...
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Spindle cell lesions of the breast: a diagnostic approach
Spindle cell lesions of the breast comprise a heterogeneous group of lesions, ranging from reactive and benign processes to aggressive malignant...
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Laryngeal Leiomyosarcoma: A Rare Case
Laryngeal leiomyosarcoma is a rare smooth muscle malignancy of the head and neck region. Diagnosis is based on immunohistochemistry. Here we present...
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Ontogenic development of the digestive tract in larval and juvenile Vimba bream, Vimba vimba
In this study we examined the ontogenic development of the digestive tract of Vimba bream ( Vimba vimba , Family: Cyprinidae) during the first 60 days...
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Breast MRI during lactation: effects on tumor conspicuity using dynamic contrast-enhanced (DCE) in comparison with diffusion tensor imaging (DTI) parametric maps
PurposeTo investigate the effect of lactation on breast cancer conspicuity on dynamic contrast-enhanced (DCE) MRI in comparison with diffusion tensor...
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Weipixiao attenuate early angiogenesis in rats with gastric precancerous lesions
BackgroundAngiogenesis is a pathobiological hallmark of gastric cancer. However, rare studies focus on angiogenesis in gastric precancerous lesions...
