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An atypical location of pineoblastoma RB1 subgroup without pineal or retinal tumor
PurposeTo describe the clinical and imaging features of a sellar-suprasellar pineoblastoma RB1 subgroup without pineal or retinal involvement.
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The first pineoblastoma case report of a patient with Sotos syndrome harboring NSD1 germline mutation
Germline mutations of NSD1 are associated with Sotos syndrome, characterized by distinctive facial features, overgrowth, and developmental delay....
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Prognostic factors and outcome of pineoblastoma: 10 years single-center experience
BackgroundThe survival of pineoblastoma patients is low, particularly in infants and those with metastatic disease. This study aimed to analyze the...
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Risk-adapted therapy and biological heterogeneity in pineoblastoma: integrated clinico-pathological analysis from the prospective, multi-center SJMB03 and SJYC07 trials
Pineoblastoma is a rare embryonal tumor of childhood that is conventionally treated with high-dose craniospinal irradiation (CSI). Multi-dimensional...
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Prognostic factors of pediatric pineal region tumors at a single institution
PurposeThis study aimed to identify factors of a worse prognosis among different histological types of pineal region tumors in pediatric patients...
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Histopathology and molecular pathology of pediatric pineal parenchymal tumors
Pineal parenchymal tumors in children are rare. They consist of two main types, pineoblastoma (PB) and pineal parenchymal tumor of intermediate...
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The effectiveness and safety of proton beam radiation therapy in children and young adults with Central Nervous System (CNS) tumours: a systematic review
BackgroundCentral nervous system (CNS) tumours account for around 25% of childhood neoplasms. With multi-modal therapy, 5-year survival is at around...
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Pineal/germ cell tumors and pineal parenchymal tumors
IntroductionPineal region tumors (PRTs) are tumors arising from the pineal gland and the paraspinal structures. These tumors are rare and...
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The first case of Ochrobactrum intermedium bacteremia in a pediatric patient with malignant tumor
BackgroundOchrobactrum spp. are non-fermenting, Gram-negative bacilli that are regarded as emerging human pathogens of low virulence that can cause...
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Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a Rare Brain Tumor Consortium registry study
Pineoblastomas (PBs) are rare, aggressive pediatric brain tumors of the pineal gland with modest overall survival despite intensive therapy. We...
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Quantifying intraventricular drug delivery utilizing programmable ventriculoperitoneal shunts as the intraventricular access device
PurposeProgrammable ventriculoperitoneal shunts (pVP shunts) are increasingly utilized for intraventricular chemotherapy, radioimmunotherapy, and/or...
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Pineal anlage tumor: clinical and diagnostic features, and rationales for treatment
PurposeTo provide a treatment-focused review and develop basic treatment guidelines for patients diagnosed with pineal anlage tumor (PAT).
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Clinicopathologic analysis of pineal parenchymal tumors of intermediate differentiation: a multi-institutional cohort study by the Kyushu Neuro-Oncology Study Group
PurposePineal parenchymal tumors of intermediate differentiation (PPTIDs), which were recognized in the 2007 World Health Organization (WHO)...
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Pediatric pineal region masses: a single-center experience over 25 years
PurposePineal region tumors (PRT) represent less than 1% of brain neoplasms. The rare and heterogeneous nature of these tumors is reflected in the...
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Temporal profile of serum melatonin levels in paediatric pineal tumours subjected to surgery: newer insights
IntroductionPineal tumours (PTs) are rare and histologically variable. Serum melatonin is a well-known product of this gland, albeit with uncertain...
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DICER1 tumor predisposition syndrome: an evolving story initiated with the pleuropulmonary blastoma
DICER1 syndrome (OMIM 606241, 601200) is a rare autosomal dominant familial tumor predisposition disorder with a heterozygous DICER1 germline...
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A case of a pineal parenchymal tumor of intermediate differentiation with bifocal lesions differentiated by negative placental alkaline phosphatase in the spinal fluid
Placental alkaline phosphatase (PLAP) in the spinal fluid is helpful for the diagnosis of intracranial germinomas. Bifocal lesions involving the...
