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Effects of a virtual voice-based coach delivering problem-solving treatment on emotional distress and brain function: a pilot RCT in depression and anxiety
Consumer-based voice assistants have the ability to deliver evidence-based treatment, but their therapeutic potential is largely unknown. In a pilot...
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Uptake and Acceptability of MyChoices: Results of a Pilot RCT of a Mobile App Designed to Increase HIV Testing and PrEP Uptake Among Young American MSM
Young men who have sex with men (YMSM) remain at disproportionate risk for HIV acquisition in the United States (US), yet use of evidence-based...
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Determining external randomised pilot trial feasibility in preparation for a definitive trial: a web-based survey of corresponding authors of external pilot trial publications
BackgroundExternal randomised pilot trials aim to determine whether a future definitive randomised controlled trial (RCT) should be conducted, and if...
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Recommendations for progression criteria during external randomised pilot trial design, conduct, analysis and reporting
BackgroundExternal randomised pilot trials aim to assess whether a future definitive Randomised Controlled Trial (RCT) is feasible. Prespecified...
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MR-guided LITT therapy in patients with primary irresectable glioblastoma: a prospective, controlled pilot study
PurposeLaser interstitial thermal therapy (LITT) is increasingly being used in the treatment of brain tumors, whereas high-quality evidence of its...
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Exploring the feasibility of conducting a randomised controlled trial of group-based pregnancy care and education: a pilot randomised controlled trial in Melbourne, Australia
BackgroundIn group-based pregnancy models, antenatal care and childbirth/parenting education are provided in groups of eight to 10 women, usually...
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PReoperative very low-Energy diets for obese PAtients undergoing non-bariatric surgery Randomized Evaluation (PREPARE): a protocol for a pilot randomized controlled trial
BackgroundPatients with obesity presenting in need of surgical intervention are at 2-to-sixfold higher risk of prolonged hospitalization, infectious...
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The MATE trial: a multicentre, mixed-methodology, pilot, randomised controlled trial in neovascular age-related macular degeneration
Background/objectivesIn healthcare research investigating complex interventions, gaps in understanding of processes can be filled by using...
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Supernatural Beliefs-Based Intervention to Improve Type-2 Diabetes Self-Management: A Pilot Randomized Controlled Trial from China
China has over 100 million people living with type 2 diabetes mellitus (T2DM). Interventions framed around pre-existing personal beliefs in the...
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Pilot randomized controlled trial of restricted versus liberal crystalloid fluid management in pediatric post-operative and trauma patients
BackgroundIntravenous (IV) fluid therapy is essential in the treatment of critically ill pediatric surgery and trauma patients. Recent studies have...
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Randomised controlled pilot trial to assess effect of electrical stimulation of weak pelvic floor muscles
Introduction and hypothesisPelvic floor muscle training (PFMT) has level 1A scientific evidence for the treatment of urinary incontinence and pelvic...
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Protocol for a pilot cluster randomised controlled trial of a multicomponent sustainable return to work IGLOo intervention
BackgroundLong-term sickness costs businesses in the United Kingdom (UK) approximately £7 billion per annum. Most long-term sickness absences are...
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A RCT to explore the effectiveness of supporting adherence to nebuliser medication in adults with cystic fibrosis: fidelity assessment of study interventions
BackgroundA multi-component self-management intervention ‘CFHealthHub’ was developed to reduce pulmonary exacerbations in adults with Cystic Fibrosis...
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A pilot randomized controlled trial evaluating outdoor community walking for knee osteoarthritis: walk
ObjectivesTo determine the feasibility of a randomized controlled trial (RCT) examining outdoor walking on knee osteoarthritis (KOA) clinical...
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Study protocol for a pragmatic cluster RCT on the effect and cost-effectiveness of Everyday Life Rehabilitation versus treatment as usual for persons with severe psychiatric disability living in sheltered or supported housing facilities
BackgroundPeople with severe psychiatric disabilities and impaired autonomy, living in sheltered or supported housing facilities, often lead...
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Flexible bronchoscopy insufflated and high-flow nasal oxygen pilot trial (BUFFALO protocol pilot trial)
BackgroundHypoxaemia occurs in approximately 30% of children during anaesthesia for flexible bronchoscopy. High-flow nasal oxygen (HFNO) can prolong...
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Multimodal exercise training to reduce frailty in people with multiple sclerosis: study protocol for a pilot randomized controlled trial
BackgroundFrailty, a syndrome characterized by decreased reserve and resistance to stressors across multiple physiologic systems, is highly prevalent...
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A pilot randomised trial comparing individualised physiotherapy versus shockwave therapy for proximal hamstring tendinopathy: a protocol
PurposeProximal hamstring tendinopathy (PHT) presents as localised lower buttock pain with tasks such as squatting and sitting. It is a condition...
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Group antenatal care: findings from a pilot randomised controlled trial of REACH Pregnancy Circles
BackgroundAntenatal care has the potential to impact positively on maternal and child outcomes, but traditional models of care in the UK have been...
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Study protocol for a randomized controlled trial with rituximab for psychotic disorder in adults (RCT-Rits)
BackgroundThe role of inflammation in the aetiology of schizophrenia has gained wide attention and research on the association shows an exponential...
