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Cardiac Effects of Phosphodiesterase-5 Inhibitors: Efficacy and Safety
The coexistence of cardiovascular disease and erectile dysfunction is widespread, possibly owing to underlying endothelial dysfunction in both...
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Inhaled Phosphodiesterase Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease
Phosphodiesterase (PDE) 4 inhibitors prevent the metabolism of cyclic adenosine monophosphate, thereby reducing inflammation. Inhaled PDE4 inhibitors...
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Efficacy of a phosphodiesterase type 5 inhibitor on the pulmonary artery index and postoperative hemodynamics after a Fontan operation
There have been no reports regarding the influence of a change in the pulmonary artery index before or after a Fontan operation. Moreover, the...
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Role of phosphodiesterase inhibitors in stent-related symptoms: a systematic review and meta-analysis
PurposeStent-related symptoms are frequent following stent placement for various indications. Use of PDE inhibitors has expanded beyond their...
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Medications mostly associated with priapism events: assessment of the 2015–2020 Food and Drug Administration (FDA) pharmacovigilance database entries
A range of drugs have a direct role in triggering ischaemic priapism. We aimed at identifying: a) which medications are associated with most...
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Assessing the Potency of the Novel Tocolytics 2-APB, Glycyl-H-1152, and HC-067047 in Pregnant Human Myometrium
The intracellular signaling pathways that regulate myometrial contractions can be targeted by drugs for tocolysis. The agents, 2-APB, glycyl-H-1152,...
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Management of use of urinary antimuscarinics and alpha blockers for benign prostatic hyperplasia in older adults at risk of falls: a clinical review
PurposeWe aimed to outline the existing information and the underlying mechanisms of risk of falls associated with the use of urinary antimuscarinics...
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The effects of epithelial–mesenchymal transitions in COPD induced by cigarette smoke: an update
Cigarette smoke is a complex aerosol containing a large number of compounds with a variety of toxicity and carcinogenicity. Long-term exposure to...
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Role of thioredoxin in chronic obstructive pulmonary disease (COPD): a promising future target
IntroductionThioredoxin (Trx) is a secretory protein that acts as an antioxidant, redox regulator, anti-allergic, and anti-inflammatory molecule. It...
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Mechanisms of oxidative stress in interstitial cystitis/bladder pain syndrome
Interstitial cystitis/bladder pain syndrome (IC/BPS) is characterized by bladder and/or pelvic pain, increased urinary urgency and frequency and...
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Recent Developments and Advances in Atopic Dermatitis: A Focus on Epidemiology, Pathophysiology, and Treatment in the Pediatric Setting
Atopic dermatitis (AD) is a chronic inflammatory skin disorder that affects a substantial number of children and has a significant negative impact on...
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Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions
Hypertension is a global public health issue and the leading cause of premature death in humans. Despite more than a century of research,...
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Skeletal and extraskeletal disorders of biomineralization
The physiological process of biomineralization is complex and deviation from it leads to a variety of diseases. Progress in the past 10 years has...
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Potential clinical biomarkers and perspectives in diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) is a serious cardiovascular complication and the leading cause of death in diabetic patients. Patients typically do not...
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Contemporary Antiplatelet and Anticoagulant Therapies for Secondary Stroke Prevention: A Narrative Review of Current Literature and Guidelines
Purpose of ReviewStroke is a leading cause of death and disability worldwide. The annual incidence of new or recurrent stroke is approximately...
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Colchicine as a Potential Therapeutic Agent Against Cardiovascular Complications of COVID-19: an Exploratory Review
Coronavirus disease-19 (COVID-19) may result in serious complications involving several organ systems, including myocardial tissue. An exaggerated...
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A preliminary study of the efficacy of the polyherbal preparation Sao Thong Tai for erectile dysfunction among elderly men: a double-blind, randomized controlled trial
BackgroundThe traditional Thai polyherbal formulation “Sao Thong Tai” (STT) contains four medicinal plants, namely Boesenbergia rotunda (L.) Mansf., S...
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Non-invasive Management Options for Erectile Dysfunction When a Phosphodiesterase Type 5 Inhibitor Fails
Phosphodiesterase type 5 inhibitors (PDE5Is) are the drug of choice for medical management of erectile dysfunction (ED). On-demand PDE5Is have an...
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Antiplatelet Drugs for Neurointerventions: Part 1 Clinical Pharmacology
The development of endovascular treatment for intracranial aneurysms has established new techniques such as balloon and stent-assistance, flow...
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BPO/LUTS – Aktuelles zur medikamentösen Therapie
“Lower urinary tract symptoms” (LUTS) are among the most common complaints of urological patients. Benign prostate enlargement represents the most...
