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Levetiracetam versus Phenobarbitone for Management of Neonatal Seizures: A Systematic Review and Meta-analysis
ObjectivesTo review whether levetiracetam is non-inferior to phenobarbitone as the first-choice antiseizure medication (ASM).
MethodsThe authors...
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Genetic Expression of CYP2B6 Gene in Phenobarbitone Responder and Non-responder Neonates
Quantitative real-time polymerase chain reaction for identifying CYP2B6 gene expression was done on blood samples of 30 phenobarbitone responder and...
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Comparison between Phenobarbitone and Levetiracetam as the initial anticonvulsant in preterm neonatal seizures — a pilot randomized control trial in develo** country setup
This study aimed to compare the efficacy and safety of intravenous Levetiracetam and Phenobarbitone in the treatment of seizures in preterm neonates....
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Toxic epidermal necrosis associated with phenobarbitone: a case report and brief review of the literatures
BackgroundToxic epidermal necrolysis (TEN)/Stevens–Johnson syndrome (SJS) is the spectrum of severe, acute, mucocutaneous, T-cell mediated delayed...
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Coexistence of mutations of Gilbert’s syndrome and Crigler-Najjar syndrome in an infant with unconjugated hyperbilirubinemia—a case report
BackgroundJaundice in the newborn period is a very common entity; rare inherited causes are often forgotten. Persistent unconjugated...
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Epilepsy surgery in pediatric refractory status epilepticus
The mainstay of status epilepticus (SE) treatment is pharmacotherapy with anti-seizure medications (ASM). In refractory status epilepticus (RSE),...
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Levetiracetam versus Phenobarbitone in Neonatal Seizures — A Randomized Controlled Trial
ObjectiveTo compare the efficacy and safety of intravenous Levetiracetam and Phenobarbitone in the treatment of neonatal seizures.
Design ... -
Clinical and Liver Biochemistry Phenotypes, and Outcome in 133 Patients with Anti-seizure Drug-Induced Liver Injury
Aims and ObjectiveAnti-seizure drugs that cause idiosyncratic drug-induced liver injury (DILI) are an important cause of morbidity and mortality in...
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Treatment of Seizures in the Neonate: Special Report From the ILAE Task Force on Neonatal Seizures, 2022
The International League Against Epilepsy (ILAE) task force on neonatal seizures has recently published draft guidelines and consensus-based...
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Late-onset vitamin K deficiency bleeding: a preventable yet prevailing cause of intracranial hemorrhage in young infants—an ambispective descriptive study
BackgroundVitamin K deficiency bleeding (VKDB) may present as intracranial hemorrhage (ICH) in young infants, which results in severe morbidity and...
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Lhermitte-Duclos disease with concomitant KCNT2 gene mutation: report of an extremely rare combination
Lhermitte-Duclos disease (LDD) refers to cerebellar dysplastic gangliocytoma, a slow-growing tumor. Pathogenic variants of voltage-gated potassium...
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Seizures after initiation of rewarming in cooled infants with hypoxic ischaemic encephalopathy
BackgroundSeizures after initiation of rewarming from therapeutic hypothermia for neonatal encephalopathy are well recognised but not easy to predict.
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