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Network pharmacology: a bright guiding light on the way to explore the personalized precise medication of traditional Chinese medicine
Network pharmacology can ascertain the therapeutic mechanism of drugs for treating diseases at the level of biological targets and pathways. The...
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Systems pharmacology dissection of pharmacological mechanisms of **aochaihu decoction against human coronavirus
BackgroundAlthough coronavirus disease 2019 (COVID-19) pandemic is still rage worldwide, there are still very limited treatments for human...
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Assessment of self-perceived knowledge of key clinical pharmacology concepts and educational needs among European Paediatric Intensive Care Units: an ESPNIC survey
BackgroundKnowledge of clinical pharmacology concepts is essential to improve patients’ outcomes. Scarce data is available on the utilisation of...
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TCMNPAS: a comprehensive analysis platform integrating network formulaology and network pharmacology for exploring traditional Chinese medicine
The application of network formulaology and network pharmacology has significantly advanced the scientific understanding of traditional Chinese...
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Network pharmacology-based strategy to investigate the effect and mechanism of α-solanine against glioma
BackgroundAn anti-tumour activity has been demonstrated for α-solanine, a bioactive compound extracted from the traditional Chinese herb Solanum...
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An Integrated Network Pharmacology and RNA-seq Approach for Exploring the Protective Effect of Andrographolide in Doxorubicin-Induced Cardiotoxicity
PurposeDoxorubicin (Dox) is clinically limited due to its dose-dependent cardiotoxicity. Andrographolide (Andro) has been confirmed to exert...
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Integrative transcriptomic and network pharmacology analysis reveals the neuroprotective role of BYHWD through enhancing autophagy by inhibiting Ctsb in intracerebral hemorrhage mice
BackgroundIn this study, we aimed to combine transcriptomic and network pharmacology to explore the crucial mRNAs and specific regulatory molecules...
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Network Pharmacology Based Elucidation of Molecular Mechanisms of Laoke Formula for Treatment of Advanced Non-Small Cell Lung Cancer
ObjectiveTo explore the specific pharmacological molecular mechanisms of Laoke Formula (LK) on treating advanced non-small cell lung cancer (NSCLC)...
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Physiology of Neuromuscular Transmission and Applied Pharmacology of Muscle Relaxants
Purpose of ReviewThe purpose of this clinical review is to summarize the physiology of the neuromuscular junction (NMJ) in the normal and denervated...
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The Efficacy of Ganoderma lucidum Extracts on Treating Endometrial Cancer: A Network Pharmacology Approach
Ganoderma lucidum (GL) is a prominent medicinal mushroom in traditional Chinese medicine, known for its potent antitumor properties. This study aimed...
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Network pharmacology study to explore the multiple molecular mechanism of SH003 in the treatment of non-small cell lung cancer
BackgroundNon-small cell lung cancer (NSCLC) is one of the leading causes of human death worldwide. Herbal prescription SH003 has been developed to...
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Network pharmacology‑based investigation of potential targets of triptonodiol acting on non-small-cell lung cancer
BackgroundTriptonodiol is a very promising antitumor drug candidate extracted from the Chinese herbal remedy Tripterygium wilfordii Hook. F., and...
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Anxiety in oncology outpatients is associated with perturbations in pathways identified in anxiety focused network pharmacology research
PurposeEvaluate for perturbed signaling pathways associated with subgroups of patients with low versus high levels of state anxiety. These pathways...
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The mechanism of action and experimental verification of Gan-song Yin on renal clear cell carcinoma based on network pharmacology and bioinformatics
BackgroundGan-song Yin (GSY) is originated from the scripture “Gan-song Pills”, a medical work of the Ningxia ethnic minorities, and its treatment of...
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Mechanisms of Bushen Tiaoxue Granules against controlled ovarian hyperstimulation-induced abnormal morphology of endometrium based on network pharmacology
Bushen Tiaoxue Granules (BTG) is an empirical Chinese herbal formula that has been used for the treatment of subfertility. The protective effect of...
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Parenteral Meperidine: a Review of the Pharmacology and Clinical Applications
Purpose of ReviewMeperidine, once one of the most widely prescribed opioids in the USA, is no longer routinely used for analgesia. This article...
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Mechanism underlying the effect of Pulsatilla decoction in hepatocellular carcinoma treatment: a network pharmacology and in vitro analysis
BackgroundCurrently, hepatocellular carcinoma (HCC) is associated with a poor prognosis. Moreover, there exist limited strategies for treating HCC....
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Medicinal Effects, Phytochemistry, Pharmacology of Euphorbia prostrata and Promising Molecular Mechanisms
Euphorbiaceae is a large family of dicotyledonous angiosperms with diverse genera including Euphorbia prostrata ( E. prostrata ). Current research has...
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Untargeted lipidomic analysis and network pharmacology for parthenolide treated papillary thyroid carcinoma cells
BackgroundWith fast rising incidence, papillary thyroid carcinoma (PTC) is the most common head and neck cancer. Parthenolide, isolated from...
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Optimizing pharmacotherapy and deprescribing strategies in older adults living with multimorbidity and polypharmacy: EuGMS SIG on pharmacology position paper
Inappropriate polypharmacy is highly prevalent among older adults and presents a significant healthcare concern. Conducting medication reviews and...