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Pharmacokinetic drug interactions of oral anticancer drugs
Over the past 20 years, oral anticancer drugs have increased in importance for the treatment of solid tumors and hematological diseases....
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Physiologically Based Pharmacokinetic Modeling to Simulate CYP3A4-Mediated Drug-Drug Interactions for Pyrotinib
IntroductionPyrotinib is a newly developed tyrosine kinase inhibitor whose in vivo clearance relies heavily on cytochrome P450 3A4 (CYP3A4) activity....
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Bidirectional pharmacokinetic drug interactions between olaparib and metformin
ObjectiveOlaparib is a PARP (poly-ADP-ribose polymerase) inhibitor used for maintenance therapy in BRCA-mutated cancers. Metformin is a first-choice...
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Clinical Evidence on the Purported Pharmacokinetic Interactions between Corticosteroids and Mycophenolic Acid
Corticosteroids (steroids) are commonly used concurrently with mycophenolic acid (MPA) as the first-line immunosuppression therapy for the prevention...
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Quantitative Prediction of Adverse Event Probability Due to Pharmacokinetic Interactions
IntroductionIatrogeny due to drug–drug interactions is insufficiently documented, due to the high number of possible combinations.
Objective ...
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Mechanisms and Clinical Significance of Pharmacokinetic Drug Interactions Mediated by FDA and EMA-approved Hepatitis C Direct-Acting Antiviral Agents
The treatment of patients infected with the hepatitis C virus (HCV) has been revolutionised by the development of direct-acting antiviral agents...
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Pharmacokinetic Interactions Between Abiraterone, Apalutamide, Darolutamide or Enzalutamide and Antithrombotic Drugs: Prediction of Clinical Events and Review of Pharmacological Information
PurposeAbiraterone, apalutamide, darolutamide and enzalutamide are second-generation hormone therapies used for advanced prostate cancer; the...
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Development of a Physiologically Based Pharmacokinetic Population Model for Diabetic Patients and its Application to Understand Disease-drug–drug Interactions
IntroductionThe activity changes of cytochrome P450 (CYP450) enzymes, along with the complicated medication scenarios in diabetes mellitus (DM)...
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Prediction of Drug–Drug Interactions After Esketamine Intranasal Administration Using a Physiologically Based Pharmacokinetic Model
Background and ObjectiveA physiologically based pharmacokinetic (PBPK) modeling approach for esketamine and its metabolite noresketamine after...
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Physiologically based pharmacokinetic modeling of ponatinib to describe drug–drug interactions in patients with cancer
PurposeThis study aimed to investigate the drug–drug interactions of ponatinib with strong, moderate, or weak CYP3A4 inhibitors/inducers by...
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General Framework to Quantitatively Predict Pharmacokinetic Induction Drug–Drug Interactions Using In Vitro Data
IntroductionMetabolic inducers can expose people with polypharmacy to adverse health outcomes. A limited fraction of potential drug–drug interactions...
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A Pharmacokinetic Drug–Drug Interactions Study between Entecavir and Hydronidone, a Potential Novel Antifibrotic Small Molecule, in Healthy Male Volunteers
IntroductionHepatic fibrosis is an inevitable process of hepatic sclerosis, malignancy, and insufficiency, and hydronidone is an innovative...
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Pharmacokinetic Interactions Between Tegoprazan and the Combination of Clarithromycin, Amoxicillin and Bismuth in Healthy Chinese Subjects: An Open-Label, Single-Center, Multiple-Dosage, Self-Controlled, Phase I Trial
BackgroundTegoprazan is a potassium-competitive acid blocker that inhibits gastric acid and which may be used for eradicating Helicobacter pylori ....
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Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug–Drug Interactions in Children
Background and ObjectiveSpinal muscular atrophy (SMA) is a progressive neuromuscular disease caused by insufficient levels of survival motor neuron...
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Clinical Pharmacokinetic and Pharmacodynamic Profile of Vericiguat
Vericiguat is an oral soluble guanylate cyclase stimulator and enhances the cyclic guanosine monophosphate pathway independently of nitric oxide as...
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Pharmacokinetic Alterations Associated with Critical Illness
Haemodynamic, metabolic, and biochemical derangements in critically ill patients affect drug pharmacokinetics and pharmacodynamics making dose...
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Interactions of selected cardiovascular active natural compounds with CXCR4 and CXCR7 receptors: a molecular docking, molecular dynamics, and pharmacokinetic/toxicity prediction study
BackgroundThe chemokine CXCL12 and its two receptors (CXCR4 and CXCR7) are involved in inflammation and hematopoietic cell trafficking. This study...
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Antiseizure Medication Interactions A Clinical Guide
This significantly revised fourth edition provides a practically orientated guide to interactions associated with antiseizure medications. It...
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Evolution of Ritlecitinib Population Pharmacokinetic Models During Clinical Drug Development
BackgroundRitlecitinib is an oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family inhibitor undergoing parallel clinical...
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Significant Effects of Renal Function on Mycophenolic Acid Total Clearance in Pediatric Kidney Transplant Recipients with Population Pharmacokinetic Modeling
Background and ObjectivesMycophenolic acid (MPA) is an immunosuppressant commonly prescribed in pediatric kidney transplantation to prevent graft...
