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Human metaphase II oocytes with narrow perivitelline space have poor fertilization, developmental, and pregnancy potentials
PurposeTo analyze the fertilization, developmental, and pregnancy potentials in oocytes with narrow perivitelline space.
MethodsPerivitelline space...
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Understanding how space travel affects the female reproductive system to the Moon and beyond
As the space industry grows exponentially and aspirations for space travel expand, we are entering a new era where we will very likely become an...
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Three-dimensional architecture of granulosa cell derived from oocyte cumulus complex, revealed by FIB-SEM
The oocyte cumulus complex is mainly composed of an oocyte, the perivitelline space, zona pellucida and numerous granulosa cells. The cumulus...
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Novel image analyser-assisted morphometric methodology offer unique opportunity for selection of embryos with potential for implantation
BackgroundPrevious studies looked into the connections between pregnancy and the Zona Pellucida (ZP) thickness and Zona Pellucida Thickness Variation...
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Mature oocyte dysmorphisms may be associated with progesterone levels, mitochondrial DNA content, and vitality in luteal granulosa cells
PurposeTo identify whether follicular environment parameters are associated with mature oocyte quality, embryological and clinical outcomes.
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Using a zebrafish xenograft tumor model to compare the efficacy and safety of VEGFR-TKIs
PurposeWe constructed a zebrafish xenograft tumor model to compare and quantify the antiangiogenic efficacy and safety of nine vascular endothelial...
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Polycystic ovary syndrome phenotype does not have impact on oocyte morphology
PurposeThe primary objective of the present study of women participating in an ICSI program was to determine whether the morphologic quality of...
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Single-cell RNA sequencing of human oocytes reveals a differential transcriptomic profile associated with agar-like zona pellucida
BackgroundAgar-like zona pellucida (ZP) is the most common type of abnormal ZP, and is one of the causes of low fertility or infertility. However,...
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Does morphological assessment predict oocyte developmental competence? A systematic review and proposed score
PurposeDoes existing scientific literature suggest an impact of oocyte dysmorphisms on biological or clinical outcomes of assisted reproduction...
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Human Oocyte Morphology and Outcomes of Infertility Treatment: a Systematic Review
Oocyte morphology assessment is easy to implement in any laboratory with possible quality grading prior to fertilization. At present, comprehensive...
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Glioblastoma research on zebrafish xenograft models: a systematic review
Glioblastoma (GBM) constitutes the most common primary brain tumor in adults. The challenges in GBM therapeutics have shed light on zebrafish used as...
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Expression of mitochondrial transcription factor A in granulosa cells: implications for oocyte maturation and in vitro fertilization outcomes
ObjectiveIn vitro fertilization-embryo transfer (IVF-ET) is a widely used treatment for infertility, with oocyte maturation and quality having a...
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Effects of indented zona pellucida on oocyte growth and development explored from changes of gene expression in cumulus cells
PurposeAbnormal Zona Pellucida (ZP) of human oocytes is an extracellular oocyte abnormality leading to subfertility or infertility, among which...
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Effect of ovarian growth factors on ultra-structural maturation in frozen human immature oocytes after in vitro maturation: a comparative study
BackgroundIn artificial reproductive technique (ART), nearly 20% of human oocytes are immature in the germinal vesicle (GV) phase. Consequently, the...
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Morphokinetic parameters of mouse oocyte meiotic maturation and cumulus expansion are not affected by reproductive age or ploidy status
IntroductionMorphokinetic analysis using a closed time-lapse monitoring system (EmbryoScope + ™) provides quantitative metrics of meiotic progression...
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Zebrafish tumour xenograft models: a prognostic approach to epithelial ovarian cancer
Epithelial ovarian cancer (EOC) is the gynaecological malignancy with highest mortality. Although adjuvant treatment with carboplatin and paclitaxel...
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Sequential embryo transfer combined with intrauterine perfusion improved pregnancy outcomes in patients with recurrent implantation failure
ObjectiveTo compare the application of sequential embryo transfer, cleavage embryo transfer, and blastocyst transfer combined with intrauterine...
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Advancements in the future of automating micromanipulation techniques in the IVF laboratory using deep convolutional neural networks
PurposeTo determine if deep learning artificial intelligence algorithms can be used to accurately identify key morphologic landmarks on oocytes and...
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Impact of endometriosis on oocyte morphology in IVF-ICSI: retrospective study of a cohort of more than 6000 mature oocytes
BackgroundInfertility associated with endometriosis can be explained by several non-exclusive mechanisms. The oocyte plays a crucial role in...