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CD8 T cell-derived perforin regulates macrophage-mediated inflammation in a murine model of gout
ObjectivesGout is characterized by hyperuricemia and recurrent inflammatory episodes caused by intra-articular crystal deposition of monosodium urate...
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Cytotoxicity of CD19-CAR-NK92 cells is primarily mediated via perforin/granzyme pathway
Chimeric antigen receptors (CARs) have improved cancer immunotherapy in recent years. Immune cells, such as Natural killer cells (NK-cells) or T...
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Immunohistochemical study of perforin and apoptosis stimulation fragment ligand (FasL)in active vitiligo
Several studies demonstrated a major pathological role of melanocyte-specific cytotoxic CD8 + T cells in the pathogenesis of vitiligo. It has been...
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SAM protects against alveolar septal cell apoptosis in autoimmune emphysema rats
BackgroundHypomethylation of the perforin gene promoter in CD4 + T cells, inflammation and oxidative stress, might be involved in alveolar septal...
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Novel mutation in perforin gene causing familial hemophagocytic lymphohistiocytosis type 2 in an Egyptian infant: case report
BackgroundHemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathological immune activation characterized by clinical signs and symptoms of...
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Granzyme serine proteases in inflammation and rheumatic diseases
Granzymes (granule-secreted enzymes) are a family of serine proteases that have been viewed as redundant cytotoxic enzymes since their discovery more...
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The cytotoxicity of γδT cells in non-small cell lung cancer mediated via coordination of the BCL-2 and AKT pathways
The effectiveness and mechanisms of γδ T-cell immunotherapy in lung cancer remain unclear. In this study, we assessed the effects of continuous,...
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Early hematopoietic cell transplantation for familial hemophagocytic lymphohistiocytosis in a regional treatment network in Japan
Familial hemophagocytic lymphohistiocytosis (FHLH) is a fatal hyperinflammation syndrome arising from the genetic defect of perforin-mediated...
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Chemotherapy resistance in acute myeloid leukemia is associated with decreased anti-tumor immune response through MHC molecule and B7 family members
Acute myeloid leukemia (AML) remains challenging due to chemotherapeutic drug-resistance (CDR). Aberrant expression B7 family proteins are involved...
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Generation and assessment of cytokine-induced killer cells for the treatment of colorectal cancer liver metastases
Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide. Cytokine-induced killer (CIK) cells are an adoptive...
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High TOX expression on CD8+ T cells in pure red cell aplasia
Thymocyte selection-associated high-mobility group box protein (TOX) is an important molecule regulating the development and exhaustion of T...
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Identification of CD8+ T cell subsets that normalize in early-treated people living with HIV receiving antiretroviral therapy
BackgroundAlthough combined antiretroviral therapy (cART) has decreased the mortality associated with HIV infection, complete immune reconstitution...
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Activation of cytotoxic lymphocytes through CD6 enhances killing of cancer cells
Immune checkpoint inhibitors (ICIs) have demonstrated efficacy and improved survival in a growing number of cancers. Despite their success, ICIs are...
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Immune characteristics and prognostic implications of mucosal-associated invariant T cells in acute myeloid leukemia
Increasing evidence suggests that mucosal-associated invariant T cells (MAITs) play a crucial role in anti-tumor responses against various cancers....
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Dynamics of pulmonary mucosal cytotoxic CD8 T-cells in people living with HIV under suppressive antiretroviral therapy
BackgroundDespite the success of antiretroviral therapy (ART), people living with HIV (PLWH) suffer from a high burden of pulmonary diseases, even...
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Murine regulatory T cells utilize granzyme B to promote tumor metastasis
Regulatory T cells (Tregs) possess a wide range of mechanisms for immune suppression. Among them, Granzyme B (GzmB) and perforin expressed by Tregs...
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Bispecific anti-CD3Ă—anti-CD155 antibody mediates T-cell immunotherapy in human haematologic malignancies
T cells are important components in the cell-mediated antitumour response. In recent years, bispecific antibodies (Bi-Abs) have become promising...
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CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy
NKT cells, unique lymphocytes bridging innate and adaptive immunity, offer significant potential for managing inflammatory disorders like asthma....
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Peripheral neuropathy associated with chronic lymphoproliferative disorders of natural killer cells (CLPD-NK): a case report and literature review
BackgroundChronic lymphoproliferative disorders of natural killer cells (CLPD-NK) is a rare lymphoproliferative disease. Peripheral neuropathy is an...
