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Effect of small peptide chelated iron on growth performance, immunity and intestinal health in weaned pigs
BackgroundSmall peptide chelated iron (SPCI), a novel iron supplementation in pig diets, owns growth-enhancing characteristics. Although a number of...
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A matter of differentiation: equine enteroids as a model for the in vivo intestinal epithelium
Epithelial damage due to gastrointestinal disorders frequently causes severe disease in horses. To study the underlying pathophysiological processes,...
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Urine metabolomics reveals biomarkers and the underlying pathogenesis of diabetic kidney disease
PurposeDiabetic kidney disease (DKD) is the most common complication of type 2 diabetes mellitus (T2DM), and its pathogenesis is not yet fully...
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Photodynamic therapy in cancer stem cells — state of the art
Despite significant efforts to control cancer progression and to improve oncology treatment outcomes, recurrence and tumor resistance are frequently...
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Effects of graded levels of microbial fermented or enzymatically treated dried brewer’s grains on growth, digestive and nutrient transporter genes expression and cost effectiveness in broiler chickens
BackgroundPoultry feed consists mainly of conventional grains and protein supplements, however, using treated unconventional agro-industrial...
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Key transporters leading to specific protoporphyrin IX accumulation in cancer cell following administration of aminolevulinic acid in photodynamic therapy/diagnosis
The administration of aminolevulinic acid allow the formation and accumulation of protoporphyrin IX specifically in cancer cells, which then lead to...
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Dietary Strategies for Managing Short Bowel Syndrome
Purpose of reviewShort bowel syndrome (SBS) is an uncommon but important disease entity. Apart from parenteral support, dietary strategies are...
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Circadian clocks in the digestive system
Many molecular, physiological and behavioural processes display distinct 24-hour rhythms that are directed by the circadian system. The master clock,...
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The intestine as an endocrine organ and the role of gut hormones in metabolic regulation
Gut hormones orchestrate pivotal physiological processes in multiple metabolically active tissues, including the pancreas, liver, adipose tissue, gut...
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Nutrient transporters: connecting cancer metabolism to therapeutic opportunities
Cancer cells rely on certain extracellular nutrients to sustain their metabolism and growth. Solute carrier (SLC) transporters enable cells to...
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Mitochondrial Dysfunction in the Pathogenesis of Preeclampsia
Purpose of ReviewPreeclampsia complicates 5–10% of all pregnancies and is a leading cause of maternal and perinatal mortality and morbidity. The...
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Learning of food preferences: mechanisms and implications for obesity & metabolic diseases
Omnivores, including rodents and humans, compose their diets from a wide variety of potential foods. Beyond the guidance of a few basic orosensory...
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Peptides, Exopolysaccharides, and Short-Chain Fatty Acids from Fermented Milk and Perspectives on Inflammatory Bowel Diseases
AbstractCrohn’s disease and ulcerative colitis are characterized by chronic inflammatory processes and an imbalanced immune response along the...
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Long-term feeding with high plant protein based diets in gilthead seabream (Sparus aurata, L.) leads to changes in the inflammatory and immune related gene expression at intestinal level
BackgroundIn order to ensure sustainability of aquaculture production of carnivourous fish species such as the gilthead seabream ( Sparus aurata ,...
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Melatonin, an ubiquitous metabolic regulator: functions, mechanisms and effects on circadian disruption and degenerative diseases
The last four decades, we assist to an increasing scientific interest on melatonin, a circadian hormone, a metabolic regulator which influences not...
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Melatonin’s neuroprotective role in mitochondria and its potential as a biomarker in aging, cognition and psychiatric disorders
Melatonin is an ancient molecule that is evident in high concentrations in various tissues throughout the body. It can be separated into two pools;...
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Potential Antibiotics for the Treatment of Neonatal Sepsis Caused by Multidrug-Resistant Bacteria
Neonatal sepsis causes up to an estimated 680,000 deaths annually worldwide, predominantly in low- and middle-income countries (LMICs). A significant...
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Identification of PEPT2 as an important candidate molecule in 5-ALA-mediated fluorescence-guided surgery in WHO grade II/III gliomas
Purpose5-aminolevulinic acid (5-ALA) fluorescence-guided surgery (FGS) appears to be a promising treatment for glioma. However, 5-ALA-mediated...
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Metabolic consequences of cystinuria
BackgroundCystinuria is an inherited disorder of renal amino acid transport that causes recurrent nephrolithiasis and significant morbidity in...
