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Therapy concepts in the context of precision medicine for pediatric malignancies—children are not adults
Cancer remains the leading cause of death from disease among children beyond the age of one. Survival of pediatric patients with cancer has...
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Precision cancer medicine and the doctor-patient relationship: a systematic review and narrative synthesis
BackgroundThe implementation of precision medicine is likely to have a huge impact on clinical cancer care, while the doctor-patient relationship is...
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Putting the “mi” in omics: discovering miRNA biomarkers for pediatric precision care
AbstractIn the past decade, growing interest in micro-ribonucleic acids (miRNAs) has catapulted these small, non-coding nucleic acids to the...
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Precision Dosing of Anti-TNF Therapy in Pediatric Inflammatory Bowel Disease
Purpose of the ReviewThis review focuses on recent advancements in anti-TNF therapeutic drug monitoring (TDM), pharmacogenetics and personalized drug...
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Genomic medicine advances for brain tumors
Cancer genome profiling has revealed important genetic alterations that serve as prognostic indicators and guides for treatment decisions, enabling...
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Innovative drugs promote precision cancer therapy
Targeted therapy has fundamentally altered the diagnosis and treatment of clinical cancers. By focusing on chromosomal abnormalities and various...
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Pediatric contributions and lessons learned from the NEPTUNE cohort study
Primary glomerular diseases are rare entities. This has hampered efforts to better understand the underlying pathobiology and to develop novel safe...
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Precision Implementation: An Approach to Mechanism Testing in Implementation Research
Advancing mechanism-focused research in implementation science is a priority given its potential to improve tailoring and efficiency of...
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Utilizing big data from electronic health records in pediatric clinical care
AbstractBig data has the capacity to transform both pediatric healthcare delivery and research, but its potential has yet to be fully realized....
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Real-World Evidence Studies in Oncology Therapeutics: Hope or Hype?
Randomized controlled trial (RCT) remains a gold standard in evidence-based medicine for assessing the efficacy and safety of cancer therapies....
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The use of machine learning and artificial intelligence within pediatric critical care
AbstractThe field of pediatric critical care has been hampered in the era of precision medicine by our inability to accurately define and subclassify...
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Novel mechanism-based treatments for pediatric anxiety and depressive disorders
Pediatric anxiety and depressive disorders are common, can be highly impairing, and can persist despite the best available treatments. Here, we...
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Pan-cancer molecular tumor board experience with biomarker-driven precision immunotherapy
Despite remarkable responses to immune checkpoint blockade (ICB) in some advanced cancers, most patients do not benefit, perhaps due to the...
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A model to implement genomic medicine in the neonatal intensive care unit
Rapid genomic sequencing has been shown to have a high diagnostic yield for critically ill infants, with multiple research studies demonstrating both...
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Precision management of acute kidney injury in the intensive care unit: current state of the art
Acute kidney injury (AKI) is a prototypical example of a common syndrome in critical illness defined by consensus. The consensus definition for AKI,...
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Pediatric biobanks to enhance clinical and translational research for children
Including children in biomedical research is an argument for continual reflection and practice refinement from an ethical and legal standpoint....
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Advances in pediatric acute kidney injury pathobiology: a report from the 26th Acute Disease Quality Initiative (ADQI) conference
BackgroundIn the past decade, there have been substantial advances in our understanding of the pathobiology of pediatric acute kidney injury (AKI)....
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Integrated PERSEVERE and endothelial biomarker risk model predicts death and persistent MODS in pediatric septic shock: a secondary analysis of a prospective observational study
BackgroundMultiple organ dysfunction syndrome (MODS) is a critical driver of sepsis morbidity and mortality in children. Early identification of...
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Pediatric sepsis biomarkers for prognostic and predictive enrichment
Sepsis is a major public health problem in children throughout the world. Given that the treatment guidelines emphasize early recognition, there is...
