Search
Search Results
-
Focused cancer pathway analysis revealed unique therapeutic targets in retinoblastoma
Retinoblastoma (RB) is a pediatric cancer of the eye that occurs in 1/15000 live births worldwide. Albeit RB is initiated by the inactivation of RB1 ...
-
Pathway analysis of sepsis-induced changes gene expression
BackgroundSepsis reaction is a response to an infection composed of genetic elements. This research aims to better understand how sepsis affects the...
-
Transcriptomics-driven metabolic pathway analysis reveals similar alterations in lipid metabolism in mouse MASH model and human
BackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver disease worldwide, and can rapidly progress...
-
Hippocampal transcriptome-wide association study and pathway analysis of mitochondrial solute carriers in Alzheimer’s disease
The etiopathogenesis of late-onset Alzheimer’s disease (AD) is increasingly recognized as the result of the combination of the aging process, toxic...
-
Zuo Gui Wan Promotes Osteogenesis via PI3K/AKT Signaling Pathway: Network Pharmacology Analysis and Experimental Validation
ObjectiveOsteogenesis is vitally important for bone defect repair, and Zuo Gui Wan (ZGW) is a classic prescription in traditional Chinese medicine...
-
Age-related changes in the healthy adult visual pathway: evidence from diffusion tensor imaging with fixel-based analysis
Background and purposeFixel-based analysis (FBA) is a new method that overcomes the technical limitations of diffusion tensor imaging (DTI) by...
-
Quantitative analysis of JAK/STAT signaling pathway in patients of inflammatory skin disorders
BackgroundInflammatory skin diseases (ISDs), are characterized by dysregulated activation of innate and adaptive immune systems, with inflammatory...
-
The Application of Deep Brain Stimulation for Parkinson’s Disease on the Motor Pathway: A Bibliometric Analysis across 10 Years
Background and ObjectiveSince its initial report by James Parkinson in 1817, Parkinson’s disease (PD) has remained a central subject of research and...
-
Analysis of proteome and post-translational modifications of 2-hydroxyisobutyrylation reveals the glycolysis pathway in oral adenoid cystic carcinoma
PurposeOral adenoid cystic carcinoma (OACC) has high rates of both local–regional recurrence and distant metastasis. The objective of this study is...
-
Barriers and Facilitators in Implementation of an Esophagectomy Care Pathway: a Qualitative Analysis
IntroductionA new postoperative esophagectomy care pathway was recently implemented at our institution. Practice pattern change among provider teams...
-
Transforming growth factors β and their signaling pathway in renal cell carcinoma and peritumoral space—transcriptome analysis
PurposeThe aim of the study was to verify hypotheses: Are transforming growth factors TGFβ1-3, their receptors TGFβI-III, and intracellular messenger...
-
Proteomic analysis of the develo** mammalian brain links PCDH19 to the Wnt/β-catenin signalling pathway
Clustering Epilepsy (CE) is a neurological disorder caused by pathogenic variants of the Protocadherin 19 (PCDH19) gene. PCDH19 encodes a protein...
-
Single-cell RNA-seq analysis reveals the Wnt/Ca2+ signaling pathway with inflammation, apoptosis in nucleus pulposus degeneration
BackgroundIncreasing studies have shown degeneration of nucleus pulposus cells (NPCs) as an critical part of the progression of intervertebral disc...
-
Machine learning-driven prediction of brain metastasis in lung adenocarcinoma using miRNA profile and target gene pathway analysis of an mRNA dataset
BackgroundBrain metastasis (BM) is common in lung adenocarcinoma (LUAD) and has a poor prognosis, necessitating predictive biomarkers. MicroRNAs...
-
Visual Pathway Recovery Post Pituitary Adenoma Surgery: Insights from Retinal Structure, Vascular Density, and Neural Conduction Analysis
IntroductionThis study investigates how surgery for pituitary adenoma (PA) affects the visual pathway, examining changes in the retina, blood vessel...
-
A systems biology approach to pathogenesis of gastric cancer: gene network modeling and pathway analysis
BackgroundGastric cancer (GC) ranks among the most common malignancies worldwide. This study aimed to find critical genes/pathways in GC pathogenesis.
...
-
Experimental verification about treatment of Bu-Shen-Yi-**g-Fang in Alzheimer’s disease by the analysis of the feasible signaling pathway of network pharmacology
ContextBu-shen-yi-**g-fang (BSYJF) has been reported to reduce amyloid-β (Aβ) 1–42 deposition in the brain of APP/PS1 mice and ameliorate cognitive...
-
Complications and visual outcomes following surgical resection of pediatric optic pathway/hypothalamic gliomas: a systematic review and meta-analysis
Pediatric optic pathway/hypothalamic gliomas (OPHG) pose challenges in treatment due to their location and proximity to vital structures. Surgical...
-
SKP alleviates the ferroptosis in diabetic kidney disease through suppression of HIF-1α/HO-1 pathway based on network pharmacology analysis and experimental validation
BackgroundDiabetic kidney disease (DKD) represents a microvascular complication of diabetes mellitus. Shenkang Pills (SKP), a traditional Chinese...
-
Patient perceptions of a remote assessment pathway in otology: a qualitative descriptive analysis
PurposeThis study aims to gain in-depth feedback on patient perceptions of remote assessment in otology, to better inform the development of a...
