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Biomarker-based staging of Alzheimer disease: rationale and clinical applications
Disease staging, whereby the spatial extent and load of brain pathology are used to estimate the severity of Alzheimer disease (AD), is pivotal to...
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Thyroid transcription factor‐1 expression in lung neuroendocrine tumours: a gender-related biomarker?
PurposeThyroid transcription factor‐1 (TTF‐1) assessed by immunohistochemistry (IHC) is a specific biomarker for lung adenocarcinoma, and is commonly...
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Decoding the glycoproteome: a new frontier for biomarker discovery in cancer
Cancer early detection and treatment response prediction continue to pose significant challenges. Cancer liquid biopsies focusing on detecting...
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Comprehensive evaluation of the relationship between biomarker profiles and neoadjuvant chemotherapy outcomes for breast cancer patients
BackgroundAccurately predicting the response to neoadjuvant chemotherapy (NAC) in breast cancer patients is crucial for guiding treatment strategies...
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Exosomal microRNAs in Parkinson’s disease: insights into biomarker potential and disease pathology
Parkinson’s disease (PD) is a prevalent neurodegenerative condition primarily affecting the elderly population. Despite its high incidence in aged...
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Changes in glutamic oxaloacetic transaminase 2 during rat physiological and pathological cardiomyocyte hypertrophy
BackgroundPhysiological and pathological cardiomyocyte hypertrophy are important pathophysiological processes of adult congenital heart...
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Vasohibin-1 Expression Can Predict Pathological Complete Remission of Advanced Bladder Cancer with Neoadjuvant Chemotherapy
Background and purposeNeoadjuvant chemotherapy (NAC) is a well-established standard practice in invasive bladder cancer (BCa), however patient...
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Functional connectivity changes in neurodegenerative biomarker-positive athletes with repeated concussions
Multimodal biomarkers may identify former contact sports athletes with repeated concussions and at risk for dementia. Our study aims to investigate...
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Proline-Rich Protein 11 Overexpression in Invasive Breast Carcinoma: A Potential Diagnosis Biomarker
PurposeThis study aims to investigated the expression of proline-rich protein 11 (PRR11) as a diagnostic biomarker of invasive breast cancer and to...
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ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711
Amyloid-β (Aβ) deposition in the brain parenchyma is one of the pathological hallmarks of Alzheimer disease (AD). We have previously identified...
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Acceptable performance of blood biomarker tests of amyloid pathology — recommendations from the Global CEO Initiative on Alzheimer’s Disease
Anti-amyloid treatments for early symptomatic Alzheimer disease have recently become clinically available in some countries, which has greatly...
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Molecular biomarker approaches to prevention of post-traumatic osteoarthritis
Up to 50% of individuals develop post-traumatic osteoarthritis (PTOA) within 10 years following knee-joint injuries such as anterior cruciate...
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The importance of CXCR4 expression in tumor stroma as a potential biomarker in pancreatic cancer
BackgroundPancreatic ductal adenocarcinoma (PDAC) is one of the main causes of cancer mortality in the world. A characteristic feature of this cancer...
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Alzheimer’s Disease Biomarker Decision-Making among Patients with Mild Cognitive Impairment and Their Care Partners
BackgroundAlzheimer’s disease (AD) biomarker tests can be ordered as part of the diagnostic workup of patients with mild cognitive impairment (MCI)....
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Systemic immune-inflammation index in dural arteriovenous fistula: a feasible biomarker reflecting its clinical characteristics
PurposeThe systemic immune-inflammation index (SII), a marker of systemic inflammation, can be calculated using peripheral blood tests. Although the...
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Identification of a potential bioinformatics-based biomarker in keloids and its correlation with immune infiltration
Keloid formation is a pathological consequence resulting from cutaneous irritation and injury, primarily attributed to excessive collagen matrix...
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BAG3 as a novel prognostic biomarker in kidney renal clear cell carcinoma correlating with immune infiltrates
PurposeBCL-2-associated athanogene 3 (BAG3) is an anti-apoptotic protein that plays an essential role in the onset and progression of multiple cancer...
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Bioimpedance based biomarker for the detection of precancerous and cancerous lesions of the pancreas: feasibility animal study
BackgroundPancreatic cancer (PC) remains a significant healthcare challenge due to its aggressive nature and poor prognosis. The current gold...
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Ethiodized oil as an imaging biomarker after conventional transarterial chemoembolization
AbstractConventional transarterial chemoembolization (cTACE) utilizing ethiodized oil as a chemotherapy carrier has become a standard treatment for...
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Measuring cfDNA integrity as a biomarker for predicting neoadjuvant chemotherapy response in breast cancer patients: a pilot study
PurposeCirculating cell-free DNA (cfDNA) is a promising biomarker for predicting treatment response and disease outcomes in Breast Cancer (BC)...
