Search
Search Results
-
Widening participation – recruitment methods in mental health randomised controlled trials: a qualitative study
BackgroundBarriers to mental health research participation are well documented including distrust of services and research; and stigma surrounding...
-
Twenty years of participation of racialised groups in type 2 diabetes randomised clinical trials: a meta-epidemiological review
Aims/hypothesisType 2 diabetes mellitus prevalence is increasing globally and the greatest burden is borne by racialised people. However, there are...
-
What is the role of randomised trials in implementation science?
BackgroundThere is a consistent demand for implementation science to inform global efforts to close the gap between evidence and practice. Key...
-
Consultations about randomised controlled trials are shorter and less in-depth for socioeconomically disadvantaged patients compared to socioeconomically advantaged patients: qualitative analysis across three trials
BackgroundPatients from socioeconomically disadvantaged backgrounds are underserved in randomised controlled trials, yet they experience a much...
-
Registry-based randomised controlled trials: conduct, advantages and challenges—a systematic review
BackgroundRegistry-based randomised controlled trials (rRCTs) have been described as pragmatic studies utilising patient data embedded in large-scale...
-
Predicting attrition of men with a history of violence from randomised clinical trials
Preventing dropout (attrition) from clinical trials is vital for improving study validity. Dropout is particularly important in justice-involved...
-
A systematic review of recruitment and retention of ethnic minorities and migrants in obesity prevention randomised controlled trials
BackgroundParticipants’ recruitment and retention into community-based interventions can be challenging, especially in research involving ethnic...
-
Factors associated with recruitment to randomised controlled trials in general practice: a systematic mixed studies review
BackgroundA common challenge for randomised controlled trials (RCTs) is recruiting enough participants to be adequately powered to answer the...
-
Undertaking multi-centre randomised controlled trials in primary care: learnings and recommendations from the PULsE-AI trial researchers
BackgroundConducting effective and translational research can be challenging and few trials undertake formal reflection exercises and disseminate...
-
Advancing cluster randomised trials in children’s therapy: a survey of the acceptability of trial behaviours to therapists and parents
BackgroundRandomised controlled trials of non-pharmacological interventions in children’s therapy are rare. This is, in part, due to the challenges...
-
Participant retention in paediatric randomised controlled trials published in six major journals 2015–2019: systematic review and meta-analysis
BackgroundThe factors which influence participant retention in paediatric randomised controlled trials are under-researched. Retention may be more...
-
A systematic review of ambulance service-based randomised controlled trials in stroke
BackgroundTreatment for stroke is time-dependent, and ambulance services play a vital role in the early recognition, assessment and transportation of...
-
Factors impacting trial participation in people with motor neuron disease
Motor neuron disease (MND) is a rapidly progressive neurodegenerative disorder with limited treatment options. Historically, neurological trials have...
-
How inclusive were UK-based randomised controlled trials of COVID-19 vaccines? A systematic review investigating enrolment of Black adults and adult ethnic minorities
ObjectivesTo establish if Black adults and adult ethnic minorities, defined as any group except White British, were represented in UK-based COVID-19...
-
Optimising recruitment in clinical trials for progressive multiple sclerosis: observational analysis from the MS-SMART and MS-STAT2 randomised controlled trials
BackgroundSlower than planned recruitment is a major factor contributing to the delay or failure of randomised controlled trials to report on time....
-
Recording harms in randomised controlled trials of behaviour change interventions: a qualitative study of UK clinical trials units and NIHR trial investigators
BackgroundHarms, also known as adverse events (AEs), are recorded and monitored in randomised controlled trials (RCTs) to ensure participants’...
-
The People’s Trial: supporting the public’s understanding of randomised trials
BackgroundRandomised trials are considered the gold standard in providing robust evidence on the effectiveness of interventions. However, there are...
-
Registry-based randomised clinical trials: a remedy for evidence-based diabetes care?
This narrative review describes a new approach to navigation in a challenging landscape of clinical drug development in diabetes. Successful outcome...
-
SMARTERscreen protocol: a three-arm cluster randomised controlled trial of patient SMS messaging in general practice to increase participation in the Australian National Bowel Cancer Screening Program
BackgroundAustralia persistently has one of the highest rates of colorectal cancer (CRC) in the world. Australia’s National Bowel Cancer Screening...
-
Reporting of PPI and the MCID in phase III/IV randomised controlled trials—a systematic review
BackgroundPatient and public involvement (PPI) in clinical trial design contributes to ensuring the research objectives and outcome measures are...
