Search
Search Results
-
Cognitive impairment and dementia in young onset Parkinson’s disease
Background and objectivePatients with young-onset Parkinson’s disease (YOPD) have a slower progression. Our aim was to analyze the change in...
-
Uric acid levels and their association with vascular dementia and Parkinson’s disease dementia: a meta-analysis
ObjectivesTo explore the association between uric acid (UA) levels and vascular dementia (VaD) and Parkinson’s disease dementia (PDD), a...
-
Different types of screen time, physical activity, and incident dementia, Parkinson’s disease, depression and multimorbidity status
BackgroundSeveral previous studies have shown that excessive screen time is associated with an increased prevalence of dementia, Parkinson’s disease...
-
Decreased aperiodic neural activity in Parkinson’s disease and dementia with Lewy bodies
Neural oscillations and signal complexity have been widely studied in neurodegenerative diseases, whereas aperiodic activity has not been explored...
-
Optimal Protocol and Clinical Usefulness of 123I-MIBG Cardiac Scintigraphy for Differentiation of Parkinson’s Disease and Dementia with Lewy Body from Non-Parkinson’s Diseases
Purpose123 I-metaiodobenzylguanidine (MIBG) cardiac scintigraphy was a useful imaging modality for the diagnosis of Parkinson’s disease, but its...
-
Protocol of a randomized controlled trial investigating Deep Brain Stimulation for MOtor symptoms in patients with Parkinson’s disease DEmentia (DBS-MODE)
BackgroundDeep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment for disabling motor symptoms of Parkinson’s...
-
Distinct tau and alpha-synuclein molecular signatures in Alzheimer’s disease with and without Lewy bodies and Parkinson’s disease with dementia
Alpha-synuclein (aSyn) pathology is present in approximately 50% of Alzheimer’s disease (AD) cases at autopsy and might impact the age-of-onset and...
-
Glymphatic function from diffusion-tensor MRI to predict conversion from mild cognitive impairment to dementia in Parkinson’s disease
BackgroundAlthough brain glymphatic dysfunction is a contributing factor to the cognitive deficits in Parkinson’s disease (PD), its role in the...
-
Dementia and Parkinson’s disease diagnoses in electronic health records vs. Medicare claims data: a study of 101,980 linked patients
BackgroundMedicare claims and electronic health record data are both commonly used for research and clinical practice improvement; however, it is not...
-
Brainstem atrophy in dementia with Lewy bodies compared with progressive supranuclear palsy and Parkinson’s disease on MRI
BackgroundAlthough Dementia with Lewy bodies (DLB) is the second most common form of dementia in elderly patients, it remains underdiagnosed compared...
-
Psychiatric Adverse Events of Acetylcholinesterase Inhibitors in Alzheimer’s Disease and Parkinson’s Dementia: Systematic Review and Meta-Analysis
BackgroundThe acetylcholinesterase inhibitors (AChEIs) donepezil, galantamine, and rivastigmine are commonly used in the management of various forms...
-
Patterns of dementia treatment in older adults with Parkinson’s disease using nationwide medical claims data
BackgroundDementia is a common feature in Parkinson’s disease (PD); however, data on dementia treatment patterns in patients with PD are scarce. This...
-
Prevalence and patterns of the concurrent use of anticholinergics for the motor symptoms of Parkinson’s disease and acetylcholinesterase inhibitors in Parkinson’s disease patients with dementia: a cross-sectional study using Korea National Health Insurance claims data
BackgroundThe concurrent use of anticholinergics and acetylcholinesterase inhibitors (ACHEIs) in Parkinson’s disease (PD) patients with dementia...
-
Parkinson’s disease with hyposmia and dysautonomia: does it represent a distinct subtype?
Background and purposeOlfactory dysfunction or dysautonomia is one of the earliest prodromal nonmotor symptoms of Parkinson’s disease (PD). We aimed...
-
Association between cerebrospinal fluid pressure and cognition in patients with Alzheimer’s disease and Lewy body dementia
BackgroundThe relationship between cerebrospinal fluid pressure (CSFP) and cognition has received little research attention. The purpose of this...
-
Cognition and Activity of Daily Living Function in people with Parkinson’s disease
The ability to perform activities of daily living (ADL) function is a multifaceted construct that reflects functionality in different daily life...
-
Predictors associated with the rate of progression of nigrostriatal degeneration in Parkinson’s disease
BackgroundParkinson’s disease (PD) manifests as a wide variety of clinical phenotypes and its progression varies greatly. However, the factors...
-
The incidence, baseline predictors, and outcomes of dementia in an incident cohort of Parkinson’s disease and controls
BackgroundThere are few long-term data on the incidence, baseline predictors, and outcomes of dementia in Parkinson’s disease (PD) from prospective...
-
Mendelian Randomization Analysis to Assess Whether Magnetic Resonance Imaging Signs of Cerebral Small Vessel Disease Can Cause Cognitive Decline and Dementia
ObjectiveCognitive decline and dementia have been linked to cerebral small vessel disease, so we explored using Mendelian randomization whether...
-
Association analyses of apolipoprotein E genotypes and cognitive performance in patients with Parkinson’s disease
BackgroundCognitive impairment is a common non-motor symptom of Parkinson’s disease (PD). The apolipoprotein E (APOE) ε4 genotype increases the risk...