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The activation of mGluR4 rescues parallel fiber synaptic transmission and LTP, motor learning and social behavior in a mouse model of Fragile X Syndrome
BackgroundFragile X syndrome (FXS), the most common inherited intellectual disability, is caused by the loss of expression of the Fragile X Messenger...
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Mechanisms of neuromodulatory volume transmission
A wealth of neuromodulatory transmitters regulate synaptic circuits in the brain. Their mode of signaling, often called volume transmission, differs...
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Better lesion conspicuity translates into improved prostate cancer detection: comparison of non-parallel-transmission-zoomed-DWI with conventional-DWI
PurposeTo compare advanced non-parallel transmission zoomed diffusion-weighted imaging (nonPTX zoom-DWI) to conventional DWI (conv-DWI) for the...
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Effect of plate orientation on apparent thickness of mineral plates by transmission electron microscopy
PurposeTransmission electron microscopy (TEM) is widely used to study the ultrastructure of bone. The mineral of bone occurs as polycrystalline...
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Discrimination of monozygotic twins using mtDNA heteroplasmy through probe capture enrichment and massively parallel sequencing
Differentiating between monozygotic (MZ) twins remains difficult because they have the same genetic makeup. Applying the traditional STR genoty**...
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Parallel evolution and control method for predicting the effectiveness of non-pharmaceutical interventions in pandemics
AimNonpharmaceutical interventions (NPIs) are important strategies to utilize in reducing the negative systemic impact pandemic disasters have on...
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Gestational valproic acid exposure enhances facial stimulation-evoked cerebellar mossy fiber-granule cell transmission via GluN2A subunit-containing NMDA receptor in offspring mice
Valproic acid (VPA) is one of the most effective antiepileptic drugs, and exposing animals to VPA during gestation has been used as a model for...
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Running in the FAMILY: understanding and predicting the intergenerational transmission of mental illness
Over 50% of children with a parent with severe mental illness will develop mental illness by early adulthood. However, intergenerational transmission...
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Spatial-temporal drivers and incidence heterogeneity of hemorrhagic fever with renal syndrome transmission in Shandong Province, China, 2016–2022
BackgroundHemorrhagic fever with renal syndrome (HFRS) signals a recurring risk in Eurasia in recent years owing to its continued rise in case...
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Levels of neutralizing antibodies against resident farm strain or vaccine strain are not indicators of protection against PRRSV-1 vertical transmission under farm conditions
BackgroundVertical transmission is key for the maintenance of porcine reproductive and respiratory syndrome virus (PRRSV) infection. In vaccinated...
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Spatial and temporal variations of flip-angle distributions in the human brain using an eight-channel parallel transmission system at 7T: comparison of three radiofrequency excitation methods
We investigated the spatial and temporal variations of flip-angle (FA) distributions in the human brain from multiple scans, using an eight-channel...
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Intergenerational Transmission of Social Anxiety: The Role of Parents’ Fear of Negative Child Evaluation and Their Self-Referent and Child-Referent Interpretation Biases
PurposeParents’ fear of negative evaluation (FNE), fear of negative child evaluation (FNCE; parents’ fear that their child is evaluated negatively by...
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Social contacts patterns relevant to the transmission of infectious diseases in Suzhou, China following the COVID-19 epidemic
BackgroundThe COVID-19 pandemic has profoundly affected human social contact patterns, but there is limited understanding regarding the post-pandemic...
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SARS-CoV-2 transmission in teenagers and young adults in Fútbol Club Barcelona’s Multidisciplinary Sports Training Academy
Most studies, aimed at determining the incidence and transmission of SARS-CoV-2 in children and teenagers, have been developed in school settings....
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Mosquito odour-baited mass trap** reduced malaria transmission intensity: a result from a controlled before-and-after intervention study
BackgroundConventional vector control strategies have significantly reduced the malaria burden. The sustainability of these methods is currently...
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Integrating Internet multisource big data to predict the occurrence and development of COVID-19 cryptic transmission
With the recent prevalence of COVID-19, cryptic transmission is worthy of attention and research. Early perception of the occurrence and development...
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Efficacy and Safety of Cryoablation Compared with Cooled Radiofrequency Ablation of Genicular Nerves in Advanced Osteoarthritis of the Knee: A Study Protocol of Single-Centric, Assessor-Blinded, Randomized, Parallel-Group, Non-inferiority Study
PurposeIn patients with symptomatic osteoarthritis knee (OAK), cryoneurolysis (CRYO) and cooled radiofrequency ablation (C-RFA) are reported to be...
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BOHEMIA: Broad One Health Endectocide-based Malaria Intervention in Africa—a phase III cluster-randomized, open-label, clinical trial to study the safety and efficacy of ivermectin mass drug administration to reduce malaria transmission in two African settings
BackgroundResidual malaria transmission is the result of adaptive mosquito behavior that allows malaria vectors to thrive and sustain transmission in...
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Omalizumab in Severe Asthma: Effect on Oral Corticosteroid Exposure and Remodeling. A Randomized Open-Label Parallel Study
IntroductionData on the clinical efficacy and remodeling of omalizumab therapy in patients on oral corticosteroids (OC) are limited.
Objective ...
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Assessment of schistosomiasis transmission in the River Nile at Greater Cairo using malacological surveys and cercariometry
Continuous field studies on the abundance and distribution of freshwater snails and cercarial populations are important for schistosomiasis control...
