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The collagen matrix regulates the survival and function of pancreatic islets
The extracellular matrix (ECM) provides an appropriate microenvironment for many kinds of cells, including pancreatic cells. Collagens are the most...
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Preclinical evaluation of Affibody molecule for PET imaging of human pancreatic islets derived from stem cells
BackgroundBeta-cell replacement methods such as transplantation of isolated donor islets have been proposed as a curative treatment of type 1...
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Interferons are key cytokines acting on pancreatic islets in type 1 diabetes
Aims/hypothesisThe proinflammatory cytokines IFN-α, IFN-γ, IL-1β and TNF-α may contribute to innate and adaptive immune responses during insulitis in...
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Pancreatic GLUT2 protein expression and isolated islets insulin secretion decreased in high-fat fed rat dams
PurposeChronic consumption of high-fat foods during the reproductive period may endanger the dams’ metabolic homeostasis and might adversely affect...
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Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h
Aims/hypothesisDisruption of pancreatic islet function and glucose homeostasis can lead to the development of sustained hyperglycaemia, beta cell...
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Unravelling innervation of pancreatic islets
The central and peripheral nervous systems play critical roles in regulating pancreatic islet function and glucose metabolism. Over the last century,...
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Glucose-stimulated insulin secretion depends on FFA1 and Gq in neonatal mouse islets
Aims/hypothesisAfter birth, the neonatal islets gradually acquire glucose-responsive insulin secretion, a process that is subjected to maternal...
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Insufficient TRPM5 Mediates Lipotoxicity-induced Pancreatic β-cell Dysfunction
ObjectiveWhile the reduction of transient receptor potential channel subfamily M member 5 (TRPM5) has been reported in islet cells from type 2...
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Circularity of islets is a distinct marker for the pathological diagnosis of adult non-neoplastic hyperinsulinemic hypoglycemia using surgical specimens
BackgroundAdult non-neoplastic hyperinsulinemic hypoglycemia (ANHH), also known as adult-onset nesidioblastosis, is a rare cause of endogenous...
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Erythropoietin exposure of isolated pancreatic islets accelerates their revascularization after transplantation
AimsThe exposure of isolated pancreatic islets to pro-angiogenic factors prior to their transplantation represents a promising strategy to accelerate...
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Prolonged culture of human pancreatic islets under glucotoxic conditions changes their acute beta cell calcium and insulin secretion glucose response curves from sigmoid to bell-shaped
Aims/hypothesisThe rapid remission of type 2 diabetes by a diet very low in energy correlates with a marked improvement in glucose-stimulated insulin...
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Improvement effects of transplanting pancreatic islet that previously incubated with biomaterials on the diabetic nephropathy in STZ- diabetic rats
BackgroundIslet transplantation is an effective treatment for diabetes or even its complications. Aim of this study is to investigate efficacy of...
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Strategies for Vascularizing Pancreatic Islets and Stem Cell–Derived Islet Organoids
Purpose of ReviewEfficiency of revascularization is one of the key factors dictating the success of islet transplantation, concerning both donor...
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Ectopic pancreatic adenocarcinoma in Meckel’s diverticulum: a case report
BackgroundMalignant neoplasms arising from Meckel’s diverticulum are rare and an adenocarcinoma in Meckel’s diverticulum originating from ectopic...
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A case of pancreatic body cancer with disappearance of the dilated pancreatic duct on the tail side during preoperative treatment
This is a case of a 67-year-old woman diagnosed with a 35-mm pancreatic body cancer with a chief complaint of epigastric discomfort. Computed...
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SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells
Aims/hypothesisIncreased circulating levels of incompletely processed insulin (i.e. proinsulin) are observed clinically in type 1 and type 2...
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Pancreatic steatosis and metabolic pancreatic disease: a new entity?
Overweight and obesity are some of the most important health challenges. Many diseases are related to these metabolic disorders, and, among them, the...
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Bioluminescence Imaging In Vivo Confirms the Viability of Pancreatic Islets Transplanted into the Greater Omentum
PurposeThe liver is the most widely used site for pancreatic islet transplantation. However, several site-specific limitations impair functional...
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Effects of photobiomodulation on glucose homeostasis and morphometric parameters in pancreatic islets of diabetic mice
High-fat diets lead to accumulation of body fat that is associated with the onset of insulin resistance and type II diabetes mellitus. On the other...
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Urolithin C alleviates pancreatic β-cell dysfunction in type 1 diabetes by activating Nrf2 signaling
AimsType 1 diabetes (T1D) is an autoimmune disorder that destroys insulin-generating pancreatic β-cells. Preserving pancreatic β-cell function is...
