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Patient-reported use of pancreatic enzyme replacement treatment (PERT) in pancreatic cancer in New Zealand and Australia: a cross-sectional survey study
PurposeThis study investigated pancreatic enzyme replacement therapy (PERT) use in people diagnosed with pancreatic cancer in New Zealand (NZ) and...
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Exocrine Pancreatic Insufficiency Dosing Guidelines for Pancreatic Enzyme Replacement Therapy Vary Widely Across Disease Types
BackgroundPancreatic enzyme replacement therapy (PERT) is the standard treatment for exocrine pancreatic insufficiency (EPI). However, many...
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Pancreatic enzyme replacement therapy in subjects with exocrine pancreatic insufficiency and diabetes mellitus: a real-life, case–control study
BackgroundExocrine pancreatic insufficiency (EPI) can be associated with all types of diabetes. Pancreatic enzyme replacement therapy (PERT) has...
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Pancreatic Enzyme Replacement Therapy in Patients with Non-pancreatic Digestive Conditions: A Nationwide Claims Analysis
Background and AimsPancreatic enzyme replacement therapy (PERT) is most commonly used to treat exocrine insufficiency related to pancreatic diseases,...
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SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells
Aims/hypothesisIncreased circulating levels of incompletely processed insulin (i.e. proinsulin) are observed clinically in type 1 and type 2...
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NEDD8-Activating Enzyme Inhibitor MLN4924 Inhibits Both the Tumor Stroma and Angiogenesis in Pancreatic Cancer via Gli1 and REDD1
PurposePancreatic cancer is characterized by a dense desmoplasia stroma, which hinders efficient drug delivery and plays a critical role in tumor...
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Gastrectomy reduces pancreatic secretory function via pancreatic atrophy
PurposeAlthough reports suggest that the pancreatic volume decreases after gastrectomy for gastric cancer, the relationship between the pancreatic...
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Impact of pancreatic ductal occlusion on postoperative outcomes in pancreatic head cancer patients undergoing neoadjuvant therapy
BackgroundPancreatic ductal occlusion can accompany pancreatic head cancer, leading to pancreatic exocrine insufficiency (PEI) and adverse effects on...
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Distinct changes to pancreatic volume rather than pancreatic autoantibody positivity: insights into immune checkpoint inhibitors induced diabetes mellitus
BackgroundImmune checkpoint inhibitors (ICI) are promising treatment options for various cancers. However, their use is associated with...
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Pancreatic injury in patients treated with immune checkpoint inhibitors: a retrospective multicenterstudy
BackgroundImmune checkpoint inhibitor-related pancreatic injury (ICI-PI) is a rare occurrence, which has not been reported in detail. We conducted a...
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Exocrine Pancreatic Insufficiency Following Gastric Resectional Surgery—is Routine Pancreatic Enzyme Replacement Therapy Necessary?
The data on exocrine pancreatic insufficiency (EPI) following gastric resectional surgery is variable, ranging from 26% to as high as 100%. This...
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Exocrine pancreatic insufficiency following bariatric surgery: unveiling alternative aetiology—case report and short review
Bariatric surgery (BS) is currently the most effective treatment for severe obesity, requiring ongoing multidisciplinary follow-up to ensure proper...
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Pancreatic Endocrine Insufficiency
Purpose of the ReviewThis review aims to consolidate the latest knowledge on type 3c diabetes mellitus (T3cDM) and its management and pancreatic...
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A case of delayed pancreatic fistula after covered self-expandable metallic stent deployment for pancreatic head cancer
A 69-year-old man was referred to our hospital with obstructive jaundice. A tumor with poor contrast enhancement was found in the pancreatic head,...
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Complementary and Integrative Medicine in Pancreatic Cancer
Purpose of ReviewPancreatic cancer has high mortality and morbidity rates, associated with the issues of typically late diagnosis and the limited...
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Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation
Aims/hypothesisType 2 diabetes is characterised by hyperglucagonaemia and perturbed function of pancreatic glucagon-secreting alpha cells but the...
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Symptoms, burden, and unmet needs of patients living with exocrine pancreatic insufficiency: a narrative review of the patient experience
Exocrine pancreatic insufficiency (EPI) stems from a deficiency of functional pancreatic enzymes with consequent maldigestion and malnutrition. EPI...
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Genetic factors and the role of pancreatic amylase in the pathogenesis of type 2 diabetes
This review article gives an insight into the genetic factors and the role of pancreatic amylase in type 2 diabetes (T2D). Diabetes is a...
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Tcf21 Alleviates Pancreatic Fibrosis by Regulating the Epithelial-Mesenchymal Transformation of Pancreatic Stellate Cells
Background and AimsThe activation of pancreatic stellate cells (PSCs) plays a key role in the occurrence and development of chronic pancreatitis (CP)...
