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Linkage Disequilibrium Score Statistic Regression for Identifying Novel Trait Associations
Purpose of ReviewIn this paper, we review the linkage disequilibrium score regression (LDSR) statistical method for computing correlation and shared...
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Pairwise genetic meta-analyses between schizophrenia and substance dependence phenotypes reveals novel association signals with pharmacological significance
Almost half of individuals diagnosed with schizophrenia also present with a substance use disorder, however, little is known about potential...
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DNMT1 SNPs (rs2114724 and rs2228611) associated with positive symptoms in Chinese patients with schizophrenia
ObjectiveSchizophrenia is a serious mental disorder with complex clinical manifestations, while its pathophysiological mechanism is not fully...
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Relationship between BDNF gene polymorphisms and alcohol-related liver cirrhosis
Background and aimBrain-derived neurotrophic factor (BDNF) functions not only in the brain but also in peripheral tissues such as the liver. Genetic...
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The association of APOH and NCF1 polymorphisms on susceptibility to recurrent pregnancy loss in women with antiphospholipid syndrome
BackgroundRecurrent pregnancy loss (RPL) is the main manifestation of pathological pregnancy in antiphospholipid syndrome (APS) women. The immune...
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Genetically predicted effects of physical activity and sedentary behavior on myasthenia gravis: evidence from mendelian randomization study
BackgroundMyasthenia gravis (MG) is an autoimmune disorder affecting the neuromuscular junction. Despite the potential benefits of higher physical...
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Population genetic analysis of 12 X-chromosomal STRs in a Swiss sample
X-chromosomal STRs are a powerful tool to assess a broad variety of complex kinship scenarios. We introduce herewith the first Swiss X-STR dataset...
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Genetic evidence for the causal relations between metabolic syndrome and psychiatric disorders: a Mendelian randomization study
Emerging evidence reveals associations between metabolic syndrome (MetS) and psychiatric disorders (PDs), although causality remains uncertain....
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Association of maternal genetic polymorphisms with fetal growth restriction syndrome in Russian pregnant women from Rostov region
BackgroundFetal growth restriction (FGR) is one of the main syndromes causing fetal morbidity and mortality. It was known to be associated with...
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Causal associations between leisure sedentary behaviors and sleep status with frailty: insight from Mendelian randomization study
BackgroundObservational studies have suggested that sedentary behaviors and sleep status are associated with frailty. However, it remains unclear...
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Study of association between different microRNA variants and the risk of idiopathic recurrent pregnancy loss
AimRecurrent pregnancy loss (RPL) is a common reproductive disorder among women and a major cause of infertility among them; however, the underlying...
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The influence of six polymorphisms of uncoupling protein 3 (UCP3) gene and childhood obesity: a case–control study
BackgroundObesity is defined as a multifactorial disease, marked by excessive accumulation of body fat, responsible for compromising the individual’s...
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KISS1 Gene Variations and Susceptibility to Idiopathic Recurrent Pregnancy Loss
It is widely accepted that kisspeptin plays an integral role in the regulation of reproduction. Genetic variations in the KISS1 gene have been...
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CYP2C19-rs4986893 confers risk to major depressive disorder and bipolar disorder in the Han Chinese population whereas ABCB1-rs1045642 acts as a protective factor
BackgroundGenetic risks may predispose individuals to major mood disorders differently. This study investigated the gene polymorphisms of previously...
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Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer’s disease and Parkinson’s disease: a large-scale multi-trait association analysis
BackgroundThe current genome-wide association study (GWAS) of Lewy body dementia (LBD) suffers from low power due to a limited sample size. In...
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Genetically proxied glucose-lowering drug target perturbation and risk of cancer: a Mendelian randomisation analysis
Aims/hypothesisEpidemiological studies have generated conflicting findings on the relationship between glucose-lowering medication use and cancer...
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HMOX1 Genetic Polymorphisms Display Ancestral Diversity and May Be Linked to Hypertensive Disorders in Pregnancy
Racial disparity exists for hypertensive disorders in pregnancy (HDP), which leads to disparate morbidity and mortality worldwide. The enzyme heme...
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The relationship between circulating metabolites and prostate hyperplasia: a Mendelian randomization study
BackgroundCirculating metabolites (CM) play a pivotal role in our overall health, yet the current evidence concerning the involvement of diverse CM...
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Gene polymorphisms of TACR1 serve as the potential pharmacogenetic predictors of response to the neurokinin-1 receptor antagonist-based antiemetic regimens: a candidate-gene association study in breast cancer patients
PurposeThe current candidate gene association study aims to investigate tag SNPs from the TACR1 gene as pharmacogenetic predictors of response to...
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Genetic evidence implicating natriuretic peptide receptor-3 in cardiovascular disease risk: a Mendelian randomization study
BackgroundC-type natriuretic peptide (CNP) is a known target for promoting growth and has been implicated as a therapeutic opportunity for the...
