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Female sex is a risk factor for painful diabetic peripheral neuropathy: the EURODIAB prospective diabetes complications study
Aims/hypothesisWhile the risk factors for diabetic peripheral neuropathy (DPN) are now well recognised, the risk factors for painful DPN remain...
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Evaluating the effect of acupuncture on symptoms of diabetic peripheral neuropathy (DPN) among individuals with diabetic neuropathy: A single-blind, randomized trial study
PurposeThis study aimed to investigate the impact of acupuncture on Diabetic peripheral neuropathy (DPN) symptoms among individuals with diabetic...
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Screening for diabetic peripheral neuropathy in resource-limited settings
BackgroundDiabetic neuropathy is the most common microvascular complication of diabetes mellitus and a major risk factor for diabetes-related...
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Monotherapy Versus Combination Therapy in the Treatment of Painful Diabetic Neuropathy: A Systematic Review and Meta-analysis
Background and ObjectivePainful peripheral neuropathy is a common and challenging complication of diabetes mellitus. Combination therapy is used...
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A Brief Review on the Novel Therapies for Painful Diabetic Neuropathy
Purpose of ReviewAlmost half of people diagnosed with diabetes mellitus will develop painful diabetic neuropathy (PDN), a condition greatly impacting...
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Efficacy and safety of duloxetine in painful diabetic peripheral neuropathy: a systematic review and meta-analysis of randomized controlled trials
BackgroundPainful diabetic peripheral neuropathy (PDPN) is a key concern in clinical practice. In this systematic review and meta-analysis, we...
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Association between phase angle and diabetic peripheral neuropathy in Type 2 diabetes patients
BackgroundDiabetic peripheral neuropathy (DPN), the very prevalent microvascular complication of type 2 diabetes mellitus (T2DM), severely threatens...
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Diabetic neuropathy: understanding the nexus of diabetic neuropathy, gut dysbiosis and cognitive impairment
ObjectivesDiabetic neuropathy is a traditional and one of the most prevalent complications of diabetes mellitus. The exact pathophysiology of...
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Biomarkers and signaling pathways of diabetic nephropathy and peripheral neuropathy: possible therapeutic intervention of rutin and quercetin
Diabetic nephropathy and peripheral neuropathy are the two main complications of chronic diabetes that contribute to high morbidity and mortality....
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A muscarinic receptor antagonist reverses multiple indices of diabetic peripheral neuropathy: preclinical and clinical studies using oxybutynin
Preclinical studies indicate that diverse muscarinic receptor antagonists, acting via the M 1 sub-type, promote neuritogenesis from sensory neurons in...
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Spinal Cord Stimulation for Painful Diabetic Peripheral Neuropathy: A Systematic Review
Painful diabetic neuropathy is a common disease that results in significant pain and disability. Treatment options have traditionally consisted of...
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Diabetic Neuropathy: Pathophysiology Review
Purpose of ReviewDiabetic neuropathy is a debilitating complication of diabetes mellitus that affects millions of individuals worldwide. It is...
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Occurrence of corneal sub-epithelial microneuromas and axonal swelling in people with diabetes with and without (painful) diabetic neuropathy
Aims/hypothesisNon-invasive in vivo corneal confocal microscopy is gaining ground as an alternative to skin punch biopsy to evaluate small-diameter...
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Effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients in southwestern Iran: a randomized clinical trial
BackgroundPeripheral neuropathy is not only the most prevalent consequence of diabetes but also the main reason for foot ulceration, disability, and...
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Classification of painful or painless diabetic peripheral neuropathy and identification of the most powerful predictors using machine learning models in large cross-sectional cohorts
BackgroundTo improve the treatment of painful Diabetic Peripheral Neuropathy (DPN) and associated co-morbidities, a better understanding of the...
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Immunoglobulin Use for the Management of Painful Peripheral Neuropathy: A Systematic Review and Meta-Analysis
BackgroundImmunoglobulins (IG) are widely used for the treatment of a variety of immune-mediated diseases. The exact mechanism of action remains...
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Comparison of therapeutic effects of N-Acetylcysteine with pregabalin in improving the clinical symptoms of painful diabetic neuropathy: a randomized, double-blind clinical trial
ObjectivesPainful diabetic neuropathy (PDN) is highly prevalent and annoyingly in patients with diabetes. The aim of this study was to investigate...
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Evidence-Based Treatment of Painful Diabetic Neuropathy: a Systematic Review
Purpose of ReviewPainful diabetic neuropathy (PDN) manifests with pain typically in the distal lower extremities and can be challenging to treat. The...
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Relationship between neutrophil to lymphocyte ratio and diabetic peripheral neuropathy: a systematic review and meta-analysis
BackgroundThe present study aims to review the existing scientific literature on the role of neutrophil to lymphocyte ratio (NLR) in diabetic...
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Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy: A Multicenter Double-Blind Randomized Controlled Trial
ObjectiveTo evaluate the effect and safety of foot baths with Tangbi Waixi Decoction (TW) in treating patients with diabetic peripheral neuropathy...