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Early diagnostic value of ECT whole-body bone imaging combined with PINP and β-CTX for bone metastasis of lung cancer
ObjectiveThis research was aimed at investigating the early diagnostic value of emission computed tomograph (ECT) whole-body bone imaging combined...
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Baseline serum PINP level is associated with the increase in hip bone mineral density seen with Romosozumab treatment in previously untreated women with osteoporosis
SummaryBaseline serum PINP value was significantly and independently associated with the increased bone mineral density (≥ 3%) in both total hip and...
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Could procollagen type I N-terminal propeptide (PINP) and bone alkaline phosphatase (B-ALP) be valid alternative diagnostic markers to dual X-ray absorptiometry (DEXA) in elderly females with osteoporosis? An Egyptian radiological and laboratory monocentric study
BackgroundOsteoporosis is a major health problem of elders. Dual X-ray absorptiometry (DEXA) is the commonly used modality for diagnosis...
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Harmonization of commercial assays for PINP; the way forward
SummaryInternational Federation of Clinical Chemistry and Laboratory Medicine and The International Osteoporosis Foundation Joint Committee on Bone...
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Do bone turnover markers reflect changes in bone microarchitecture during treatment of patients with thyroid dysfunction?
PurposeThis study aimed to compare changes in the bone turnover markers (BTMs)—C-terminal telopeptide of type I collagen (CTX-I) and procollagen I...
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Negative impact on bone homeostasis in postmenopausal women with non-metastatic breast cancer during cytotoxic chemotherapy
IntroductionThe burden and mechanisms of endocrine therapy-related bone loss are well known, while there are limited data on chemotherapy-induced...
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Analyzing the factors associated with efficacy among teriparatide treatment in postmenopausal women with osteoporosis
BackgroundTeriparatide (TPTD) is a widely used anabolic agent for the treatment of osteoporosis. Several factors have been identified to be related...
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Correlation between bone density, bone metabolism markers with lipid metabolism markers and body mass index
PurposeWe aimed to explore the relationship between bone mineral density (BMD), bone metabolism markers, and blood lipid-related indicators, body...
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Predictors of bone mineral density in patients receiving glucocorticoid replacement for Addison’s disease
PurposePatients receiving long-term glucocorticoid (GC) treatment are at risk of osteoporosis, while bone effects of substitution doses in Addison’s...
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The clinical utility of TRACP-5b to monitor anti-resorptive treatments of osteoporosis
SummaryTRACP-5b can be used to monitor the response of treatments in osteoporosis. We investigated the effect of feeding on levels of TRACP-5b and...
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Fracture-induced changes in biomarkers CTX, PINP, OC, and BAP—a systematic review
To assess the time from fracture until bone turnover markers (BTM), which are biochemical markers reflecting in vivo bone formation and resorptive...
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Baseline bone turnover marker levels can predict change in bone mineral density during antiresorptive treatment in osteoporotic patients: the Copenhagen bone turnover marker study
SummaryAnti-resorptive osteoporosis treatment might be more effective in patients with high bone turnover. In this registry study including clinical...
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The relationship between estimated glucose disposal rate and bone turnover markers in type 2 diabetes mellitus
PurposeTo investigate the relationship between estimated glucose disposal rate (eGDR) and bone turnover markers in patients with type 2 diabetes...
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Chinese medicine Gushukang capsule for treating primary osteoporosis: a systematic review and meta-analysis
ObjectiveTo systematically evaluate the efficacy and safety of Gushukang (GSK) capsules in the treatment of primary osteoporosis.
Methods ...
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MiR-210 improves postmenopausal osteoporosis in ovariectomized rats through activating VEGF/Notch signaling pathway
BackgroundTo explore the effect and mechanism of action of miR-210 on postmenopausal osteoporosis (PMPO) in ovariectomized rats in vivo.
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Association of bone turnover markers and cognitive function in Chinese chronic schizophrenia patients with or without vitamin D insufficiency
BackgroundIncreasing evidence shows that bone turnover markers (BTMs) and vitamin D can affect human cognitive function. However, there are few...
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Age-related changes and reference intervals of RANKL, OPG, and bone turnover markers in Indian women
SummaryRANKL and OPG are cytokines involved in bone remodeling that makes them potential bone biomarkers. The reference interval for these cytokines,...
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Effects of weight loss on bone turnover, inflammatory cytokines, and adipokines in Chinese overweight and obese adults
PurposePlenty of studies have examined the long term effect of weight loss on bone mineral density. This study aimed to explore the effects of 10%...
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Age-related trends and reference intervals of cross-linked C-telopeptide of type I collagen and procollagen type I N-propeptide from a reference population of Sri Lankan adult women
SummaryRefer ence values of bone turnover markers (BTMs) are determined by factors that are country-specific. In Sri Lanka, unavailability of BTM...
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Effects of intermittent hypoxia and whole-body vibration training on health-related outcomes in older adults
BackgroundAging is associated with a health impairment and an increase of the vulnerability of the older people. Strength training under intermittent...