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Next-generation microbiological testing in intraabdominal infections with PCR technology
PurposeIntraabdominal infections (IAI) are increasing worldwide and are a major contributor to morbidity and mortality. Among IAI, the number of...
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Utility of Film Array Meningoencephalitis Panel in Children With Acute Encephalitis Syndrome: A Single Centre Experience from South India
ObjectiveTo describe the utility of film array meningoencephalitis (FAME) panel in the management of children with acute encephalitis syndrome (AES).
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Development and validation of multiplex real-time PCR for simultaneous detection of six bacterial pathogens causing lower respiratory tract infections and antimicrobial resistance genes
BackgroundKlebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa , Escherichia coli, Streptococcus pneumoniae and Staphylococcus aureus ...
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Etiology of acute febrile illness in the peruvian amazon as determined by modular formatted quantitative PCR: a protocol for RIVERA, a health facility-based case-control study
BackgroundThe study of the etiology of acute febrile illness (AFI) has historically been designed as a prevalence of pathogens detected from a case...
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The routine use of LCD-Array hybridisation technique for HPV subty** in the diagnosis of penile carcinoma compared to other methods
BackgroundRoutine human papillomavirus (HPV) testing is performed in cervival cancer and is required for classification of some head and neck...
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Proof of concept for multiplex detection of antibodies against Chlamydia species in chicken serum using a bead-based suspension array with peptides as antigens
The available differentiating tests for Chlamydia are based on detection of genetic material and only give information about the actual infection...
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Expanding the scope of methylation-sensitive restriction enzyme (MSRE) PCR for forensic identification of body fluids through the novel use of methylation-dependent restriction enzymes (MDRE) and the combination of autosomal and Y-chromosomal markers
Methylation-sensitive/-dependent restriction enzyme (MSRE/MDRE) PCR can be performed to detect hypomethylated or hypermethylated CpG sites. With the...
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Array study in fetuses with nuchal translucency above the 95th percentile: a 4-year observational single-centre study
PurposeTo evaluate the performance of chromosomal microarray analysis (CMA) in fetuses with nuchal translucency (NT) > 95th percentile. Secondary...
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Comparison of bacterial culture with BioFire® FilmArray® multiplex PCR screening of archived cerebrospinal fluid specimens from children with suspected bacterial meningitis in Nigeria
BackgroundDiagnosis of bacterial meningitis remains a challenge in most develo** countries due to low yield from bacterial culture, widespread use...
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Surgical site infections by atypical mycobacteria: prevalence and species characterization using MALDI-TOF and molecular LCD chip array
BackgroundSurgical site infection (SSI) is a post-operative complication of high concern with adverse impact on patient prognosis and public health...
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Digital droplet PCR-based quantification of ccfHPV-DNA as liquid biopsy in HPV-driven cervical and vulvar cancer
PurposeMore than 99% of cervical cancers and up to 40% of vulvar cancers are human papillomavirus (HPV) related. HPV 16 and 18 are the most relevant...
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A heatmap for expected cumulative live birth rate in preimplantation genetic testing for monogenic disorders and chromosomal structural rearrangements
PurposeOur objective is to predict the cumulative live birth rate (CLBR) and identify the specific subset within the population undergoing...
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Focused cancer pathway analysis revealed unique therapeutic targets in retinoblastoma
Retinoblastoma (RB) is a pediatric cancer of the eye that occurs in 1/15000 live births worldwide. Albeit RB is initiated by the inactivation of RB1 ...
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Application of array comparative genomic hybridization (aCGH) for identification of chromosomal aberrations in the recurrent pregnancy loss
Spontaneous abortion occurs in 8–20% of recognized pregnancies and usually takes place in the first trimester (7–11 weeks). There are many causes of...
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The clinical impact of multiplex PCR panel diagnostics in paediatric meningitis/ encephalitis: a bicenter cohort study
PurposeIn infections of the Central Nervous System (iCNS), rapid identification of causing pathogens is crucial for survival and to avoid long-term...
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Apoptotic qPCR gene expression array analysis demonstrates proof-of-concept for rapid blastocoel fluid-conditioned media molecular prediction
PurposeSuccessful identification of transcriptomic biomarkers within human IVF embryos may enhance implantation prediction and provide insights not...
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Machine Learning Successfully Detects Patients with COVID-19 Prior to PCR Results and Predicts Their Survival Based on Standard Laboratory Parameters in an Observational Study
IntroductionIn the current COVID-19 pandemic, clinicians require a manageable set of decisive parameters that can be used to (i) rapidly identify...
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Signature pattern of gene expression and signaling pathway in premature diabetic patients uncover their correlation to early age coronary heart disease
BackgroundCoronary Heart Disease (CHD) is the leading cause of death in industrialized countries. There is currently no direct relation between CHD...
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Evaluation of TaqMan Array card (TAC) for the detection of 28 respiratory pathogens
BackgroundRespiratory infections are a serious threat to human health. So, rapid detection of all respiratory pathogens can facilitate prompt...
