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PCP4/PEP19 downregulates neurite outgrowth via transcriptional regulation of Ascl1 and NeuroD1 expression in human neuroblastoma M17 cells
Purkinje cell protein 4/peptide 19 (PCP4/PEP19) is 7.6 kDa peptide originally found in Purkinje cells. PCP4/PEP19 is a differentiation maker of...
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Expression, Regulation, and Function of the Calmodulin Accessory Protein PCP4/PEP-19 in Myometrium
Objective: Calmodulin (CaM) plays a key role in the orchestration of Ca 2+ signaling events, and its regulation is considered an important component...
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Screening and validation of plasma cell-derived, purinergic, and calcium signalling-related genetic signature to predict prognosis and PD-L1/PD-1 blockade responses in lung adenocarcinoma
BackgroundThis study aims at screening and validation of prospective genetic signature for lung adenocarcinoma (LUAD) prognosis and treatment.
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Effects of steam on polysaccharides from Polygonatum cyrtonema based on saccharide map** analysis and pharmacological activity assays
BackgroundPolygonatum cyrtonema, one of origins of Polygonata Rhizoma ( Huang**g in Chinese), is traditionally steamed repeatedly before being used...
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Underlying motivations hampering Flemish primary care physicians from overcoming the barriers in osteoporosis care: an EMR-facilitated clinical reasoning study
BackgroundOver half of the European population aged minimum 65 years presents with at least two chronic diseases. Attention towards these diseases...
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FGF21 modulates hippocampal cold-shock proteins and CA2-subregion proteins in neonatal mice with hypoxia–ischemia
BackgroundFibroblast growth factor 21 (FGF21) is a neuroprotectant with cognitive enhancing effects but with poorly characterized mechanism(s) of...
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Tackling Guideline Non-concordance: Primary Care Barriers to Incorporating Life Expectancy into Lung Cancer Screening Decision-Making—A Qualitative Study
BackgroundPrimary care providers (PCPs) are often the first point of contact for discussing lung cancer screening (LCS) with patients. While...
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Barriers, facilitators and needs to deprescribe benzodiazepines and other sedatives in older adults: a mixed methods study of primary care provider perspectives
BackgroundBenzodiazepines and other sedative hypnotic drugs (BSHs) are frequently prescribed for sleep problems, but cause substantial adverse...
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Primary care clinician perspectives on automated nephrology e-consults for diabetic kidney disease: a pre-implementation qualitative study
BackgroundMany patients with diabetic kidney disease (DKD) do not receive evidence-based, guideline-recommended treatment shown to reduce DKD...
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The role of LncRNAs and CircRNAs in osteoporosis: a focus on osteogenesis and osteoclastogenesis signaling pathways
BackgroundOsteoporosis is a crucial health concern interconnected with physical disabilities as well as financial burdens. It arises from an...
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Atypical perineuronal nets in the CA2 region interfere with social memory in a mouse model of social dysfunction
Social memory dysfunction is an especially devastating symptom of many neuropsychiatric disorders, which makes understanding the cellular and...
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Bioinformatics Analysis Reveals Novel Differentially Expressed Genes Between Ectopic and Eutopic Endometrium in Women with Endometriosis
BackgroundEndometriosis is one of the chronic and prevalent diseases among women. There is limited knowledge about its pathophysiology at the...
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Qualitative investigation of patient and carer experiences of everyday legal needs towards end of life
BackgroundLegal issues are common in chronic illness. These include matters of daily life, such as problems with employment, finances and housing,...
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Proteomics analysis of a human brain sample from a mucolipidosis type IV patient reveals pathophysiological pathways
BackgroundMucolipidosis type IV (MLIV), an ultra-rare neurodevelopmental and neurodegenerative disorder, is caused by mutations in the MCOLN1 gene,...
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Overexpression of INSM1, NOTCH1, NEUROD1, and YAP1 genes is associated with adverse clinical outcome in pediatric neuroblastoma
Pediatric neuroblastoma is responsible for approximately 8–10% of pediatric tumors, and it is one of the leading causes of tumor-related deaths in...
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Primary aldosteronism: molecular medicine meets public health
Primary aldosteronism is the most common single cause of hypertension and is potentially curable when only one adrenal gland is the culprit. The...
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Complement-associated loss of CA2 inhibitory synapses in the demyelinated hippocampus impairs memory
The complement system is implicated in synapse loss in the MS hippocampus, but the functional consequences of synapse loss remain poorly understood....
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Enkephalin release from VIP interneurons in the hippocampal CA2/3a region mediates heterosynaptic plasticity and social memory
The hippocampus contains a diverse array of inhibitory interneurons that gate information flow through local cortico-hippocampal circuits to regulate...
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Systematic review and integrated analysis of prognostic gene signatures for prostate cancer patients
Prostate cancer (PC) is one of the most common cancers in men and becoming the second leading cause of cancer fatalities. At present, the lack of...
