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Identification of Molecular Markers Predicting the Outcome of Anti-thrombotic Therapy After Percutaneous Coronary Intervention in Patients with Acute Coronary Syndrome and Atrial fibrillation: Evidence from a Meta-analysis and Experimental Study
Acute coronary syndrome (ACS) and atrial fibrillation (AF) often coexist in clinical practice, and patients with these conditions often have a...
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Screening and validation of plasma cell-derived, purinergic, and calcium signalling-related genetic signature to predict prognosis and PD-L1/PD-1 blockade responses in lung adenocarcinoma
BackgroundThis study aims at screening and validation of prospective genetic signature for lung adenocarcinoma (LUAD) prognosis and treatment.
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Risk factors analysis and survival prediction model establishment of patients with lung adenocarcinoma based on different pyroptosis-related gene subtypes
BackgroundLung adenocarcinoma (LUAD) is a common cancer with a poor prognosis. Pyroptosis is an important process in the development and progression...
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Exploring key molecular signatures of immune responses and pathways associated with tuberculosis in comorbid diabetes mellitus: a systems biology approach
BackgroundComorbid type 2 diabetes mellitus (T2DM) increases the risk for tuberculosis (TB) and its associated complications, although the...
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Liquid biopsy using non-coding RNAs and extracellular vesicles for breast cancer management
This article examines liquid biopsy using non-coding RNAs and extracellular vesicles in detail. Liquid biopsy is emerging as a prominent non-invasive...
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Transcriptome-wide association study identifies novel genes associated with bone mineral density and lean body mass in children
ObjectiveTo identify novel candidate genes whose expression is associated with bone mineral density (BMD) and body lean mass (LM) in children.
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Splenic proteome profiling in response to Marek’s disease virus strain GX0101 infection
Marek’s disease virus (MDV) strain GX0101 was the first reported field strain of recombinant gallid herpesvirus type 2 (GaHV-2). However, the splenic...
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P2x4 receptor promotes mammary cancer progression by sustaining autophagy and associated mesenchymal transition
Metastatic progression is a major burden for breast cancer patients and is associated with the ability of cancer cells to overcome stressful...
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Identification of a novel immune checkpoint molecule V-set immunoglobulin domain-containing 4 that leads to impaired immunity infiltration in pancreatic ductal adenocarcinoma
BackgroundCheckpoint-based immunotherapy has failed to elicit responses in the majority of patients with pancreatic cancer. In our study, we aimed to...
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Altered purinergic receptor expression in the frontal cortex in schizophrenia
ATP functions as a neurotransmitter, acting on the ubiquitously expressed family of purinergic P2 receptors. In schizophrenia (SCZ), the pathways...
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Dl-3-n-butylphthalide attenuates mouse behavioral deficits to chronic social defeat stress by regulating energy metabolism via AKT/CREB signaling pathway
Major depressive disorder (MDD) is a severe mental disorder associated with high rates of morbidity and mortality. Current first-line...
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Genetic and chemical targeting of the ATPase complex TIP48 and 49 impairs acute myeloid leukemia
The chromatin-associated AAA+ ATPases Tip48 and Tip49 are the core components of various complexes implicated in diverse nuclear events such as DNA...
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Identification of hub genes related to the progression of type 1 diabetes by computational analysis
BackgroundType 1 diabetes (T1D) is a serious threat to childhood life and has fairly complicated pathogenesis. Profound attempts have been made to...
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Methylation across the central dogma in health and diseases: new therapeutic strategies
The proper transfer of genetic information from DNA to RNA to protein is essential for cell-fate control, development, and health. Methylation of...
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White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy
Multiple system atrophy (MSA) is a fatal late-onset neurodegenerative disease. Although presenting with distinct pathological hallmarks, which in MSA...
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ANP32A regulates histone H3 acetylation and promotes leukemogenesis
Deregulation of key regulators of histone modification is important in the initiation and progression of human leukemia. Acidic leucine-rich nuclear...
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RNA-Seq Analysis of Islets to Characterise the Dedifferentiation in Type 2 Diabetes Model Mice db/db
Type 2 diabetes (T2D) is a global health issue and dedifferentiation plays underlying causes in the pathophysiology of T2D; however, there is a lack...
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Mouse pancreatic islet macrophages use locally released ATP to monitor beta cell activity
Aims/hypothesisTissue-resident macrophages sense the microenvironment and respond by producing signals that act locally to maintain a stable tissue...
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Identification of key pathways and genes in colorectal cancer using bioinformatics analysis
Colorectal cancer (CRC) is the most common malignant tumor of digestive system. The aim of this study was to identify gene signatures during CRC and...
