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Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) alleviate excessive autophagy of ovarian granular cells through VEGFA/PI3K/AKT/mTOR pathway in premature ovarian failure rat model
BackgroundPremature ovarian failure (POF) is one of the leading causes of female infertility and is accompanied by abnormal endocrine, seriously...
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Human mesenchymal stem cells derived exosomes improve ovarian function in chemotherapy-induced premature ovarian insufficiency mice by inhibiting ferroptosis through Nrf2/GPX4 pathway
BackgroundChemotherapy exposure has become a main cause of premature ovarian insufficiency (POI). This study aimed to evaluate the role and molecular...
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The mechanisms of MicroRNA 21 in premature ovarian insufficiency mice with mesenchymal stem cells transplantation
Umbilical cord-derived mesenchymal stem cell (UCMSC) transplantation has been deeply explored for premature ovarian insufficiency (POI) disease....
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In-vitro generation of follicle-like structures from human germ cell-like cells derived from theca stem cell combined with ovarian somatic cells
BackgroundThe objective of this study was to induce the differentiation of human theca stem cells (hTSCs) into germ cell-like cells (hGCLCs) and...
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In-vivo oogenesis of oogonial and mesenchymal stem cells seeded in transplanted ovarian extracellular matrix
Objective (s)One way to overcome the recurrence of cancer cells following ovarian tissue transplantation is to use decellularized tissues as a...
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Stem cell-assisted enzyme/prodrug therapy makes drug-resistant ovarian cancer cells vulnerable to natural killer cells through upregulation of NKG2D ligands
Cancer stem-like cells (CSCs) are believed to be responsible for cancer recurrence and metastasis. Therefore, a therapeutic approach is needed to...
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Differentially expression and function of circular RNAs in ovarian cancer stem cells
BackgroundCircular RNAs (circRNAs) are noncoding RNAs that regulate miRNA expression; however, their functions in cancer stem cells (CSCs) are not...
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Transcription factor ZIC2 regulates the tumorigenic phenotypes associated with both bulk and cancer stem cells in epithelial ovarian cancer
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy in North America. Current therapeutic regimens are ineffective against...
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Placental mesenchymal stem cells ameliorate NLRP3 inflammasome-induced ovarian insufficiency by modulating macrophage M2 polarization
BackgroundPremature ovarian insufficiency (POI) is a common clinical problem, however, there are currently no effective therapies. Pyroptosis induced...
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Conservative Hypomethylation of Mesenchymal Stem Cells and Their Secretome Restored the Follicular Development in Cisplatin-Induced Premature Ovarian Failure Mice
Premature ovarian failure (POF) is one of the main causes of infertility in women under the age of 40 years. Recently , epigenetic reprogramming,...
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Cancer Stem Cells (CD44+/CD24−), RAD6, DDB2 Immunohistochemistry Expression and IHC-UNEDO Scoring System As Predictor of Ovarian Cancer Chemoresistance
BackgroundsOvarian cancer is a deadly women cancer with many chemoresistance after standard treatment. Ovarian cancer tissues’ CD44 + /CD24 − (CSCs),...
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Chito-oligosaccharides and macrophages have synergistic effects on improving ovarian stem cells function by regulating inflammatory factors
BackgroundChronic low-grade inflammation and ovarian germline stem cells (OGSCs) aging are important reasons for the decline of ovarian reserve...
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Cancer stemness kinase inhibitor amcasertib: a promising therapeutic agent in ovarian cancer stem and cancer cell models with different genetic profiles
Ovarian cancer, often referred to as the ‘silent killer,’ is a significant contributor to mortality rates. Emerging evidence implicates Nanog as a...
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The effect of human menstrual blood-derived stem cells on ovarian folliculogenesis, angiogenesis and collagen volume in female rats affected by the polycystic ovary syndrome
BackgroundInfertility is one of the common problems among couples, affecting millions of people worldwide. Polycystic ovary syndrome (PCOS) is one of...
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Identification of microRNA expression profiles of CD44+ ovarian cancer stem cells
PurposeThe aim of our study was to investigate microRNA (miRNA) expression profiles in CD44 + ovarian cancer stem cells (ovarian CSCs).
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Co-culture of human cryopreserved fragmented ovarian tissue with theca progenitor cells derived from theca stem cells
PurposeDespite the significant advances in the in vitro development of human primordial follicles, it is still a challenging approach with great...
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Ovarian tissue cryopreservation for fertility preservation before hematopoietic stem cell transplantation in patients with sickle cell disease: safety, ovarian function follow-up, and results of ovarian tissue transplantation
PurposeTo describe the experience of performing ovarian tissue cryopreservation (OTC) before hematopoietic stem cell transplantation (HSCT), among...
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Development and clinical validation of a seven-gene signature based on tumor stem cell-related genes to predict ovarian cancer prognosis
ObjectiveTumors are highly heterogeneous, and within their parenchyma, a small population of tumor-stem cells possessing differentiation potential,...
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Polyploidy, EZH2 upregulation, and transformation in cytomegalovirus-infected human ovarian epithelial cells
Human cytomegalovirus (HCMV) infection has been implicated in epithelial ovarian cancer (OC). Polyploidy giant cancer cells (PGCCs) have been...
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Endometrial stem cells alleviate cisplatin-induced ferroptosis of granulosa cells by regulating Nrf2 expression
BackgroundPremature ovarian failure (POF) caused by cisplatin is a severe and intractable sequela for young women with cancer who received...
