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Granulosa Cells-Related MicroRNAs in Ovarian Diseases: Mechanism, Facts and Perspectives
MicroRNAs (miRNAs) are a class of short single-stranded, noncoding RNAs that affect the translation of mRNAs by imperfectly binding to homologous...
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Human granulosa cells of poor ovarian responder patients display telomeres shortening
ObjectiveWe aimed to compare the telomere length in granulosa cells of the young normal and poor ovarian responder patients and elderly patients...
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Mitochondrial Morphology and Function Abnormality in Ovarian Granulosa Cells of Patients with Diminished Ovarian Reserve
In this study, we examined the changes in the mitochondrial structure and function in cumulus granulosa cells of patients with diminished ovarian...
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Effect of TSH on aromatase expression of ovarian granulosa cells in obese mice
PurposeAromatase plays an important role in ovarian development, the normal progress of the menstrual cycle, and fertility status. Elevated aromatase...
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Extraction and identification of exosomes from three different sources of human ovarian granulosa cells and analysis of their differential miRNA expression profiles
ObjectiveAs important functional cells in the ovary, ovarian granulosa cells are involved in the regulation of oocyte growth and development and play...
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Co-cultivation of human granulosa cells with ovarian cancer cells leads to a significant increase in progesterone production
PurposeIn humans, granulosa cells (GCs) are part of the follicle and nourish the growing oocyte. GCs produce estrogen and, after ovulation,...
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Extra Ovarian Adult Granulosa Cell Tumor: A Rare Clinical Case Report
Adult ovarian granulosa cell tumor is one of the rare types of malignant tumor, which arises from the sex cord granulosa cell of the ovary. The tumor...
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Interaction of lncRNA Gm2044 and EEF2 promotes estradiol synthesis in ovarian follicular granulosa cells
The functions and molecular mechanisms of long noncoding RNA (lncRNA) in reproduction have been widely studied at present. However, lncRNA regulating...
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MicroRNA-144-3p protects against chemotherapy-induced apoptosis of ovarian granulosa cells and activation of primordial follicles by targeting MAP3K9
Premature ovarian failure (POF) is defined by amenorrhea, ovarian atrophy, hypoestrogenism, elevated gonadotropin level, and infertility under the...
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Melatonin suppresses serum starvation-induced autophagy of ovarian granulosa cells in premature ovarian insufficiency
ObjectivesPremature ovarian insufficiency (POI) refers to the decline and cessation of ovarian functions in women under 40 years of age. Melatonin...
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Cai’s prescription inhibits granulosa cell apoptosis through ARHGAP4 on poor ovarian responders
PurposePoor ovarian response (POR) is a big challenge for in vitro fertilization. The traditional Chinese medicine, Cai’s Prescription of Tonifying...
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Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging
BackgroundWith advanced maternal age, abnormalities during oocyte meiosis increase significantly. Aneuploidy is an important reason for the reduction...
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LncRNA SNHG12 promotes cell proliferation and inhibits apoptosis of granulosa cells in polycystic ovarian syndrome by sponging miR-129 and miR-125b
BackgroundPolycystic ovarian syndrome (PCOS) is the most common endocrine disease in women of childbearing age which is often associated with...
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Resveratrol-βcd inhibited premature ovarian insufficiency progression by regulating granulosa cell autophagy
BackgroundThe ovarian environment of premature ovarian insufficiency (POI) patients exhibits immune dysregulation, which leads to excessive secretion...
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GIMAP7 induces oxidative stress and apoptosis of ovarian granulosa cells in polycystic ovary syndrome by inhibiting sonic hedgehog signalling pathway
Polycystic ovary syndrome (PCOS) is a gynaecological endocrine disease. The objective of the present study was to investigate the role of GTPase...
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Endometrial stem cells alleviate cisplatin-induced ferroptosis of granulosa cells by regulating Nrf2 expression
BackgroundPremature ovarian failure (POF) caused by cisplatin is a severe and intractable sequela for young women with cancer who received...
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Transcriptomic profiling of human granulosa cells between women with advanced maternal age with different ovarian reserve
BackgroundAge-related diminished ovarian reserve (DOR) is not absolute. Some advanced maternal age (AMA) still have normal ovarian reserve (NOR) and...
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Reduced PATL2 Impairs the Proliferation of Ovarian Granulosa Cells by Decreasing ADM2 Expression in Patients with PCOS
It is recognized that PCOS patients are often accompanied with aberrant follicular development, which is an important factor leading to infertility...
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LncRNA DANCR counteracts premature ovarian insufficiency by regulating the senescence process of granulosa cells through stabilizing the interaction between p53 and hNRNPC
BackgroundPremature ovarian insufficiency (POI) is one of the common women reproductive endocrine diseases which adversely impacts female fertility,...
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lncRNA-FMR6 directly binds SAV1 to increase apoptosis of granulosa cells in premature ovarian failure
BackgroundA regulatory mechanism of lncRNA binding to protein has been detected in premature ovarian failure (POF). Therefore, this study was...
